A5007597546- Global Health Workforce Issues
- Esophageal and GI Pathology
- Smoking Behavior and Cessation
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Nutrition and Health in Aging
- Esophageal Cancer Research and Treatment
- Musculoskeletal pain and rehabilitation
- Blood transfusion and management
- Obesity, Physical Activity, Diet
- Neuroscience of respiration and sleep
- Child and Adolescent Psychosocial and Emotional Development
- Infant Health and Development
- Narrative Theory and Analysis
- Digital Games and Media
- Employment, Labor, and Gender Studies
- Marine Biology and Ecology Research
- Health Systems, Economic Evaluations, Quality of Life
- Economic theories and models
- Pathogenesis and Treatment of Hiccups
- Cardiac and Coronary Surgery Techniques
- Gastrointestinal motility and disorders
- Sport Psychology and Performance
- Primary Care and Health Outcomes
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Language Development and Disorders
University of Leicester
2014-2025
BlackRock (United States)
2022
Medivir (Sweden)
2022
Homerton University Hospital NHS Foundation Trust
2021
The University of Melbourne
2020
Austin Health
2020
Peninsula Health
2020
Eastern Health
2016-2020
Monash Health
2016-2020
Monash University
2016-2020
Most patients with irritable bowel syndrome (IBS) are managed in primary care. When first-line therapies for IBS ineffective, the UK National Institute Health and Care Excellence guideline suggests considering low- dose tricyclic antidepressants as second-line treatment, but their effectiveness care is unknown, they infrequently prescribed this setting.
Poor nutrition in the first months after oesophago-gastric resection is a contributing factor to reduced quality of life seen these patients. The aim this pilot and feasibility study was ascertain conducting multi-centre randomised controlled trial evaluate routine home enteral Patients undergoing oesophagectomy or total gastrectomy were either six weeks feeding through jejunostomy (intervention), treatment as usual (control). Intervention comprised overnight feeding, providing 50 % energy...
Since 2015, the Complex Reviews Synthesis Unit (CRSU) has developed a suite of web-based applications (apps) that conduct complex evidence synthesis meta-analyses through point-and-click interfaces. This been achieved in R programming language by combining existing packages meta-analysis with shiny web-application package. The CRSU apps have evolved from two short-term student projects into eight are used for more than 3,000 h per month. Here, we present our experience developing production...
Background There is good evidence that therapist-delivered interventions have modest beneficial effects for people with low back pain (LBP). Identification of subgroups LBP who may benefit from these different treatment approaches an important research priority. Aim and objectives To improve the clinical effectiveness cost-effectiveness by providing patients, their advisors health-service purchasers better information about which participants are most likely to choices. Our were synthesise...
Experimental studies suggest that mechanical cell washing to remove pro-inflammatory components accumulate in the supernatant of stored donor red blood cells (RBCs) might reduce inflammation and organ injury transfused patients.Cardiac surgery patients at increased risk large-volume RBC transfusion were eligible. Participants randomized receive either mechanically washed allogenic RBCs or standard care RBCs. The primary outcome was serum interleukin-8 measured baseline four postsurgery time...
Significance Statement Although most patients with CKD are managed in the primary care setting, evidence base for general practice is scant, and it not clear whether specific management programs can alter outcomes care. The authors conducted a cluster randomized, controlled trial comparing 23 practices offering usual which nurse practitioner helped those interpret patient data files implement guideline-based interventions. They found that intervention did affect rate of eGFR decline, but...
Bitcoin (BTC) returns exhibit pronounced positive skewness with a third central moment of approximately 150% per year. They are well characterized by mixture Normals distribution one "normal" regime and small probability "bliss" where the price appreciation is more than 100 times at annual horizon. The large right-tail skew induces investors who prefer to add significant BTC holdings equity-bond portfolios. Even when forecasted lose half its value in normal regime, power utility optimally 3%...
Around 20% of 1- to 4-month-old infants cry for long periods without an apparent reason. Traditionally, this was attributed gastrointestinal disorder ('colic'), but evidence shows that just 5% a lot because organic disturbances; in most cases, the crying is attributable normal developmental processes. This has led focus on impact parents. Parental vulnerabilities influence how parents evaluate and respond predict adverse outcomes. By developing evidence-based services support parents, study...
Foreword from Acting Administrator of the Health Resources and Services Administration (HRSA) Associate Federal Office Rural Policy (FORHP), U.S. Department Human Jim Macrae, MA, MPP (bio) Tom Morris, MPA As for (FORHP) Services, we welcome you to this special theme issue that features promising evidence-based solutions longstanding rural health care delivery quality issues. This supplement spotlights methods stakeholders have employed address concerns disease burden in communities lack...
Abstract Background During the first 4 months of age, approximately 20% infants cry a lot without an apparent reason. Most research has targeted crying, but impact crying on parents, and subsequent outcomes, need to receive equal attention. This study reports findings from prospective evaluation package materials designed support well‐being mental health parents who judge their infant be excessively. The resulting “Surviving Crying” comprised website, printed materials, programme Cognitive...
Chronic obstructive pulmonary disease (COPD) is a complex lung characterized by airways inflammation and tissue remodeling, leading to loss of small emphysema.1 It the fourth cause death in United States, responsible for more than 150,000 deaths yearly.2 More 15 million people have been diagnosed with COPD and, compared 4.7% large metropolitan areas, staggering 8.2% those living rural areas disease.2 That translates about 3.5 people, it does not include estimated additional 1 undiagnosed.2,...
Irritable bowel syndrome with diarrhoea (IBS-D) affects up to 4% of the general population. Symptoms include frequent, loose, or watery stools associated urgency, resulting in marked reduction quality life and loss work productivity. Ondansetron, a 5HT3 receptor antagonist, has had an excellent safety record for over 20 years as antiemetic, yet is not widely used treatment IBS-D. It has, however, been shown slow colonic transit small randomised, placebo-controlled, cross-over pilot study,...
Tailoring is a frequent component of approaches for implementing clinical practice guidelines, although evidence on how to maximise the effectiveness tailoring limited. In England, overweight and obesity are common, national guidelines have been produced by National Institute Health Care Excellence. However, not routinely followed in primary care. A tailored implementation intervention was developed following an analysis determinants influencing selection strategies address determinants....
Acute kidney injury (AKI) is a common and severe complication of cardiac surgery. There no effective prevention or treatment. Sildenafil citrate (Revatio® , Pfizer Inc.), phosphodiesterase type 5 inhibitor, prevents post surgery AKI in pre-clinical studies, however its use contraindicated patients with symptomatic cardiovascular disease. The aim this study to assess the safety pharmacokinetics intravenous sildenafil patients.We conducted an open label, dose escalation six per level. doses...
The 'Surviving Crying' study was designed to develop and provisionally evaluate a support service for parents of excessively crying babies, including its suitability use in the United Kingdom (UK) National Health Service (NHS). resulting includes three materials: website, printed booklet, Cognitive Behaviour Therapy (CBT) programme delivered by qualified professional. This aimed measure whether used materials obtain parents' NHS professionals' evaluations they are fit purpose. Parents were...
Abstract There is a growing recognition of the importance pre‐literacy skills among pre‐school children. Evidence that children from relatively deprived backgrounds face poorer outcomes in speech and language development educational achievement has led to an assertive attempt lessen social inequalities at earliest opportunity. The UK government‐funded Sure Start initiative aims provide services promote play learning opportunities for such under age four. This paper describes background...