A5022240306- Chronic Kidney Disease and Diabetes
- Dialysis and Renal Disease Management
- COVID-19 Clinical Research Studies
- Blood Pressure and Hypertension Studies
- Diabetes Treatment and Management
- Health Systems, Economic Evaluations, Quality of Life
- Healthcare cost, quality, practices
- Chronic Disease Management Strategies
- Lipoproteins and Cardiovascular Health
- Antiplatelet Therapy and Cardiovascular Diseases
- Pharmaceutical Economics and Policy
- Acute Kidney Injury Research
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Renal and Vascular Pathologies
- Renal Diseases and Glomerulopathies
- Nutrition and Health in Aging
- COVID-19 and healthcare impacts
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Venous Thromboembolism Diagnosis and Management
- Intensive Care Unit Cognitive Disorders
- Healthcare Policy and Management
- Inflammatory mediators and NSAID effects
- Muscle and Compartmental Disorders
- Vitamin D Research Studies
University Hospitals of Leicester NHS Trust
2015-2025
University of Leicester
2015-2025
Leicester General Hospital
2014-2023
RELX Group (United States)
2022
Kettering General Hospital
2019-2020
National Health Service
2019
Norfolk and Norwich University Hospital
2010
IgA nephropathy (IgAN) is an important cause of ESKD for which there are no approved therapies. A challenge evaluating treatments IgAN the usual long time course progression to ESKD. The aim this Kidney Health Initiative project was identify surrogate end points that could serve as reliable predictors a treatment’s effect on long-term kidney outcomes in and be used basis approval. Proteinuria identified most widely recognized well studied risk factor IgAN. workgroup performed critical review...
Background The Kidney Failure Risk Equation (KFRE) uses the 4 variables of age, sex, urine albumin-to-creatinine ratio (ACR), and estimated glomerular filtration rate (eGFR) in individuals with chronic kidney disease (CKD) to predict risk end stage renal (ESRD), i.e., need for dialysis or a transplant, within 2 5 years. Currently, national guideline writers UK other countries are evaluating role KFRE referrals from primary care secondary care, but has had limited external validation care....
Chronic kidney disease (CKD) measures (estimated glomerular filtration rate [eGFR] and albuminuria) are frequently assessed in clinical practice improve the prediction of incident cardiovascular (CVD), yet most major guidelines do not have a standardized approach for incorporating these into CVD risk prediction. "CKD Patch" is validated method to calibrate predicted from established equations according CKD measures.Utilizing data 4,143,535 adults 35 datasets, we developed several Patches"...
Abstract Aims The 2021 European Society of Cardiology (ESC) guideline on cardiovascular disease (CVD) prevention categorizes moderate and severe chronic kidney (CKD) as high very-high CVD risk status regardless other factors like age does not include estimated glomerular filtration rate (eGFR) albuminuria in its algorithms, systemic coronary estimation 2 (SCORE2) older persons (SCORE2-OP), to predict risk. We developed validated an ‘Add-on’ incorporate CKD measures into these using a...
The kidney failure risk equation (KFRE) uses age, sex, GFR, and urine albumin-to-creatinine ratio (ACR) to predict 2- 5-year of in populations with eGFR <60 ml/min per 1.73 m 2 . However, the CKD-EPI 2021 creatinine for is now recommended use but has not been fully tested context KFRE. In 59 cohorts comprising 312,424 patients CKD, authors assessed predictive performance calibration associated whether additional variables accounting competing death improves KFRE's performance. KFRE generally...
<h3>Background</h3> To assess if ultrasound measurement of the optic nerve sheath diameter (ONSD) can accurately predict presence raised intracranial pressure (ICP) and acute pathology in patients emergency department. <h3>Methods</h3> This 3-month prospective observational study used to measure ONSD adult who required CT from The mean both eyes was measured using a 7.5 MHz probe on closed eyelids. A value >0.5 cm taken as positive. Two radiologists independently assessed scans population...
Abstract Patients with chronic kidney disease (CKD) exhibit reduced exercise capacity, poor physical function and symptoms of fatigue. The mechanisms that contribute to this are not clearly defined but may involve reductions in mitochondrial function, mass biogenesis. Here we report on the effect non‐dialysis dependent CKD (NDD‐CKD) basal expression transcription factors involved biogenesis compared a healthy control cohort (HC). In addition, sought investigate 12‐week exercise‐training...
Chronic kidney disease (CKD) increases risk of cardiovascular (CVD). Less is known about how CVD associates with future failure replacement therapy (KFRT).
N/A
Abstract Early diagnosis, risk stratification and medication optimisation are essential to improve the management of chronic kidney disease other long-term conditions. The introduction Integrated Care Systems in England provides opportunity revolutionise these Annual NHS costs ∼£6.4 billion. We designed, piloted implemented at scale an System-level virtual care programme for disease, ‘Leicester, Leicestershire, Rutland Chronic Kidney Disease Delivery Project’ (LUCID), based on principles...
Background National Institute for Health and Care Excellence 2021 guidelines on chronic kidney disease (CKD) recommend the use of Kidney Failure Risk Equation (KFRE), which includes measurement albuminuria. The equation to calculate estimated glomerular filtration rate (eGFR) has also been updated. Aim To investigate impact KFRE updated eGFR CKD diagnosis (eGFR <60 mL/min/1.73 m 2 ) in primary care potential referrals nephrology. Design setting Primary database (Secure Anonymised...
Electronic health records are being increasingly used in medical research to answer more relevant and detailed clinical questions; however, they pose new significant methodological challenges. For instance, observation times likely correlated with the underlying disease severity: Patients worse conditions utilise care may have biomarker values recorded. Traditional methods for analysing longitudinal data assume independence between severity; yet, data, such assumptions unlikely hold. Through...
Significance Statement Although most patients with CKD are managed in the primary care setting, evidence base for general practice is scant, and it not clear whether specific management programs can alter outcomes care. The authors conducted a cluster randomized, controlled trial comparing 23 practices offering usual which nurse practitioner helped those interpret patient data files implement guideline-based interventions. They found that intervention did affect rate of eGFR decline, but...