A5050300735- Pain Mechanisms and Treatments
- Indigenous Health, Education, and Rights
- Musculoskeletal pain and rehabilitation
- Ethics in Clinical Research
- Neuroscience, Education and Cognitive Function
- Autism Spectrum Disorder Research
- Ion channel regulation and function
- Indigenous Studies and Ecology
- Anesthesia and Pain Management
- Neurobiology and Insect Physiology Research
- Insect Utilization and Effects
- Ion Channels and Receptors
- Family and Disability Support Research
- Consumer Attitudes and Food Labeling
- Aging and Gerontology Research
- Assistive Technology in Communication and Mobility
- Antibiotics Pharmacokinetics and Efficacy
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Neural and Behavioral Psychology Studies
- Motor Control and Adaptation
- Clinical Reasoning and Diagnostic Skills
- Surgical site infection prevention
- Food Security and Health in Diverse Populations
- Public-Private Partnership Projects
- Global Health and Surgery
Leicestershire Partnership NHS Trust
2025
NeuroDevNet
2020-2023
University of British Columbia
2020-2023
Deleted Institution
2021-2023
Centre de Calcul de l’Institut National de Physique Nucléaire et de Physique des Particules
2021
British Columbia Children's Hospital
2018
University College London
2001-2013
University College London Hospitals NHS Foundation Trust
2005-2013
Royal London Hospital
2002-2005
National Hospital for Neurology and Neurosurgery
2002-2005
OBJECTIVES: To design and test a brief, efficient dementia‐screening instrument for use by general practitioners (GPs). DESIGN: The General Practitioner Assessment of Cognition (GPCOG) consists cognitive items historical questions asked an informant. validity the measure was assessed comparison with criterion standard diagnoses dementia derived from Diagnostic Statistical Manual Mental Disorders (Fourth Edition). SETTING: Primary care doctors' offices. PARTICIPANTS: Sixty‐seven GPs...
Abstract Early diagnosis, risk stratification and medication optimisation are essential to improve the management of chronic kidney disease other long-term conditions. The introduction Integrated Care Systems in England provides opportunity revolutionise these Annual NHS costs ∼£6.4 billion. We designed, piloted implemented at scale an System-level virtual care programme for disease, ‘Leicester, Leicestershire, Rutland Chronic Kidney Disease Delivery Project’ (LUCID), based on principles...
Background Postherpetic neuralgia remains a difficult problem to treat. A number of therapies have been shown be effective, but some patients intractable pain. Patient The case 76-year-old woman whose pain had resistant standard is described. pattern quantitative sensory testing results for this patient led the authors believe that she an "irritable nociceptor" type pathophysiology. Intervention was instructed apply neat peppermint oil (containing 10% menthol) her skin, resulting in almost...
Over the years, term private sector development, has been misunderstood and misconstrued - variously vilified sanctified. During decade of 1990s, role in economic received increased attention, with controversy surrounding such issues as privatization, corporate scandals. This book provides first comprehensive treatment topic. Central to discussion, is design public policy that promotes an appropriate balance between competition, regulation. It places special emphasis on means by which...
To investigate the effects of gabapentin, carbamazepine, and amitriptyline on temporal summation, simple nociceptive pain, innocuous touch sensation in healthy volunteers.A placebo controlled four-way crossover double-blind randomized protocol was followed. Seventeen subjects, male female, aged 18 to 24, took part. Punctate summation pain repeat punctate stimulation, vibration detection threshold were assessed triplicate. Study drugs given as bedtime early morning doses with assessments...
Peripheral administration of the nociceptive agent capsaicin is used as an experimental tool to study neurophysiological and pharmacological aspects generation control pain. When investigating secondary hyperalgesia phenomena, current topical intradermal delivery methods have two key limitations. Intradermal injection can evoke severe chemogenic pain both produce unstable area dynamic mechanical allodynia. We present validity studies a new preparation for that overcomes these The novel...
The relationship between thermal detection threshold and rate of temperature change the stimulus when slow (<1 degrees C s(-1)) rates are employed was investigated. Using both reaction time (RT) inclusive Method Limits RT exclusive Levels healthy volunteers had warming (WDT) cooling thresholds (CDT) measured at four different (0.3, 0.5, 0.7 1.0 from thenar and/or mental regions using a contact thermode. With Limits, CDT increased linearly with suggesting increments were due to artefacts....
Abstract Background Behavioural and emotional problems are a salient concern for parents of children with neurodisability, but little is known about the nature such concerns in this population, nor distribution types across ostensibly different subpopulations. Methods Information behavioural was extracted from clinical reports developmental paediatricians ( N = 12) who had assessed aged 3 to 8 years 129) through three clinics at major rehabilitation service centre. All were captured granular...
We studied pharmacokinetics of chloramphenicol in 9 neonates having a mean gestational age 31.2 ± 1.9 weeks (mean SEM). The dose was the final treatment 8 these and first 2 these. 1 neonate twice. Concentrations its 3-monosuccinate 1-monosuccinate esters were measured serum by high performance liquid chromatography. Apparent total body clearance correlated with postnatal (r = 0.81, p < 0.01). Mean apparent 1.1 ml · min^-1 kg^-1. Serum concentrations succinate below assay sensitivity after 6...
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PMP-D2, a novel 35 amino acid peptide isolated from the brain of locust Locusta migratoria, is localised specifically in neurosecretory cells and nerve tracts Pars intercerebralis. When PMP-D2 applied onto rat sensory neurones it blocks high voltage-activated inward Ca2+ currents at concentrations ranging 0.1 mu M to 10 M. The inhibitory effect more marked on sustained current measured end 100 ms voltage step commands than maximum current. These results suggests that may differentially...
System logs are a wealth of information that can be leveraged to control the behaviour computing and storage infrastructure, detect deviations from normal behaviour, react accordingly by triggering some predefined actions. log management usually consists complex workflow collects, standardises, indexes, stores, visualises messages help system administration teams in their daily operations. In large scale data centres such infrastructures collect millions if not billions per day. A key...