A5081767805- Gastrointestinal motility and disorders
- Music Therapy and Health
- Palliative Care and End-of-Life Issues
- Genomics and Chromatin Dynamics
- Health Systems, Economic Evaluations, Quality of Life
- Pathogenesis and Treatment of Hiccups
- Frailty in Older Adults
- Neonatal Respiratory Health Research
- BRCA gene mutations in cancer
- Cancer-related Molecular Pathways
- Cystic Fibrosis Research Advances
- Disaster Response and Management
- Complementary and Alternative Medicine Studies
- Ubiquitin and proteasome pathways
- Patient Satisfaction in Healthcare
- Trauma Management and Diagnosis
- Clinical practice guidelines implementation
- Epigenetics and DNA Methylation
- Lung Cancer Diagnosis and Treatment
- DNA Repair Mechanisms
- COVID-19 and healthcare impacts
- Pleural and Pulmonary Diseases
- Hip and Femur Fractures
- Emergency and Acute Care Studies
- Cancer-related molecular mechanisms research
University of York
2012-2025
University of Exeter
2022-2024
University of Leeds
2023-2024
Most patients with irritable bowel syndrome (IBS) are managed in primary care. When first-line therapies for IBS ineffective, the UK National Institute Health and Care Excellence guideline suggests considering low- dose tricyclic antidepressants as second-line treatment, but their effectiveness care is unknown, they infrequently prescribed this setting.
CIZ1 is part of the RNA-dependent supramolecular assemblies that form around inactive X-chromosome (Xi) in female cells and smaller throughout nucleus both sexes. Here, we show C-terminal anchor domain (AD) elevated human breast tumor transcriptomes, even at stage I. Elevation correlates with deprotection chromatin upregulation lncRNA-containing gene clusters ∼10 Mb regions enriched cancer-associated genes. We modeled effect AD on endogenous CIZ1–Xi observed dominant-negative interference...
Background: Irritable bowel syndrome (IBS) can cause troublesome symptoms impacting patients’ quality of life and incur considerable health service resource use. Guidelines suggest low-dose amitriptyline for IBS as second line treatment, but this is rarely prescribed in primary care. Aim: To explore general practitioners’ (GPs) views experiences using IBS. Design Setting: Qualitative interview study with patients GPs England, nested within the ATLANTIS trial versus placebo ( ISRCTN48075063...
Background Irritable bowel syndrome, characterised by abdominal pain and a change in stool form or frequency, is most often managed primary care. When first-line therapies are ineffective, National Institute for Health Care Excellence guidelines suggest considering low-dose tricyclic antidepressants as second-line treatment, but their effectiveness care unknown they infrequently prescribed general practitioners. Objective To evaluate the clinical cost-effectiveness of titrated amitriptyline...
Irritable bowel syndrome (IBS) is a common functional disorder that has considerable impact on patient quality of life and substantial societal health care resource costs. Current treatments are often ineffective. Tricyclic antidepressants have shown promise in secondary populations but their effectiveness primary setting remains unclear.ATLANTIS randomised, multi-centre, parallel-group, two-arm, double-blind, placebo-controlled trial low-dose amitriptyline as second-line treatment for IBS...
Abstract CIZ1 is a nuclear matrix protein that part of the large RNA-dependent supramolecular assembly complexes (SMACs) form at inactive X chromosome (Xi) in female cells, and smaller assemblies throughout nucleus males females. It plays role maintenance epigenetic state gene expression differentiated via stabilisation histone post-translational modifications H2AK119ub1 H3K27me3, added by polycomb repressive (PRC) 1 2. Here, we show N-terminal replication domain (RD) C-terminal anchor (AD)...
<h3>Introduction</h3> IBS impacts patients' quality of life and has substantial societal health care resource costs. NICE guidelines recommend considering low-dose amitriptyline if first line treatments are ineffective. However, evidence for patients in primary is unclear few GPs currently prescribe IBS. <h3>Methods</h3> NIHR HTA-funded double-blind, randomised, placebo-controlled, superiority trial (10–30mg participant self-titrated) adults with care. <i>Eligibility:</i> Adults ongoing...
Background A high proportion of patients do not regain outdoor mobility after hip fracture. Rehabilitation explicitly targeting is needed to enable these older adults recover activities which they value most. The overarching aim this study determine the feasibility a randomised controlled trial aims assess clinical- and cost-effectiveness an intervention designed recovery among fracture (the OUTDOOR intervention). Methods This protocol for multi-centre pragmatic parallel group (allocation...
To evaluate the impact of usual care plus a fundamental nursing guideline compared to only for patients in hospital with COVID-19 on patient experience, quality, functional ability, treatment outcomes, nurses' moral distress, health-related quality life and cost-effectiveness.
Introduction Secondary spontaneous pneumothorax (SSP) is a medical emergency where the lung collapses in presence of underlying chronic disease. Current international clinical guidelines advise intercostal drain (ICD) insertion for SSP. However, previous small study needle aspiration (NA) has been shown to reduce length hospital stay (LOHS) and complications. We are evaluating cost-effectiveness an initial NA approach management patients with SSP United Kingdom. Methods analysis The...
<h3>Context:</h3> Most patients with irritable bowel syndrome (IBS) are managed in primary care. If first-line therapies ineffective, UK NICE Guidelines suggests considering low dose tricyclic antidepressants (TCAs), but effectiveness care is unknown and TCA infrequently prescribed for IBS this setting. <h3>Objective:</h3> To determine the clinical of amitriptyline (10-30mg) adults <h3>Study Design Analysis:</h3> Randomised, double-blind, placebo-controlled trial. Participants, clinicians,...
Abstract The DNA replication protein Ciz1 promotes initiation of mammalian in cooperation with cyclin A-dependent kinase, most likely by delivering A to sites where E-dependent pre-replication complex assembly has taken place. Normally, is anchored within nuclear matrix-associated foci that co-localize replication, but the absence anchor domain retains ability promote isolated nuclei so attachment matrix not essential for function. Expression and domains are uncoupled uneven at transcript...
Background: The COVID-19 pandemic highlighted nursing as a key driver of patient experience, satisfaction,safety, clinical effectiveness, care quality, and treatment outcomes. Despite facing unprecedented challenges in delivering fundamental the pandemic, nurses had no trial evidence to aid practice. We aimed robustly evaluate guideline developed specifically for patients with COVID-19.Methods: In this parallel two-arm, cluster-level randomised controlled we recruited: (i) adults aged 18...