A5065954659- Schizophrenia research and treatment
- Mental Health and Psychiatry
- Psychosomatic Disorders and Their Treatments
- Psychotherapy Techniques and Applications
- Mental Health Treatment and Access
- Personality Disorders and Psychopathology
- Child and Adolescent Psychosocial and Emotional Development
- Digital Mental Health Interventions
- Medication Adherence and Compliance
- Mental Health Research Topics
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Psychiatric care and mental health services
- Synthetic Organic Chemistry Methods
- Microbial Natural Products and Biosynthesis
- Health Literacy and Information Accessibility
- Healthcare Decision-Making and Restraints
- Technology and Human Factors in Education and Health
- Homicide, Infanticide, and Child Abuse
- Traditional and Medicinal Uses of Annonaceae
- Sport Psychology and Performance
- Mental Health and Patient Involvement
- Meta-analysis and systematic reviews
- Hallucinations in medical conditions
- Pathogenesis and Treatment of Hiccups
- Statistical Methods in Clinical Trials
University of Manchester
2015-2025
Pennine Care NHS Foundation Trust
2018-2025
Manchester Academic Health Science Centre
2016-2025
University of Sheffield
2024-2025
National Health Service
2021-2025
University of Leeds
2021-2024
Health Sciences Centre
2022
Greater Manchester Mental Health NHS Foundation Trust
2017
Lancashire Care NHS Foundation Trust
2015-2016
Centre for Mental Health
2008-2014
Psychosis is relatively common, with schizophrenia being the most prevalent form of psychotic disorder, affecting about seven in 1000 adults, onset typically occurring between ages 15 and 35.1 These disorders, which are characterised by distressing hallucinations delusions, disturbed behaviour, memory motivation problems, present a major personal,2 social,3 clinical,4 financial5 challenge. Moreover, poor physical health strongly associated schizophrenia, men dying 20 years earlier than...
Attention-deficit/hyperactivity disorder (ADHD) is a common childhood condition that may affect different areas of the child's life, seriously impairing academic achievement, peer relationships, and self care. Many affected children become socially isolated develop conduct problems. Some 15% with ADHD will still have in adulthood, even more personality and/or substance misuse adulthood.1 2 3 Diagnosis rates for prescriptions stimulant medication risen substantially England during past...
Reductive alkylation of 5-methoxy-1-tetralone (6) with 2,3-dibromopropene gave an equilibrium mixture bicyclic diones 7 (51%) and 8 (35%). Radical cyclization afforded tricyclic dione 5 (84%), which was reduced, cyclized, dehydrated to give tetracyclic alkene 13 in 63% yield. Allylic oxidation SeO2 activated MnO2 enone 2 85% yield, thereby completing a short formal synthesis (±)-platensimycin.
Psychosis, including schizophrenia, comprises a major group of psychiatric disorders characterised by hallucinations and/or delusions (psychotic symptoms) that alter perception, thoughts, affect, and behaviour, which can considerably impair child or young person’s development, relationships, physical health. Schizophrenia is estimated to affect 1.6 1.9 per 100 000 in the population,1 2 with prevalence increasing rapidly from age 14.3 Psychosis schizophrenia children (age 12 years under)...
There is a wealth of evidence to suggest that the Borderline Personality Disorder (BPD, or similar Emotionally Unstable Disorder, EUPD) construct harmful. We provide commentary on ideas expressed in May Debate issue, highlighting both concerns and alternatives.We bring together lived experience, clinical research expertise. This was written collaboratively drawing all these sources evidence.We outline BPD invalid, harmful, not necessary for effective treatment potential block development...
Abstract Background In psychosis spectrum disorders, maladaptive mental imagery is associated with auditory verbal hallucinations (AVHs). This study evaluates the feasibility, acceptability, and effectiveness of following 4 techniques in targeting AVHs severity: Imagery Rescripting (ImRs), Promoting positive de novo (Pos-Im), Metacognitive (Meta-Im), playing Tetris. Study Design Four replicated single-case series experimental designs were used. Participants randomized to 1 treatment...
Abstract Background Parenting experiences during childhood have been suggested to inform the development of an individual's attachment style and core schemas. Additionally, parenting, schemas all individually linked symptoms psychosis in adulthood. However, there is limited research drawing together these concepts understand process by which parenting influences The current study, therefore, aimed test a serial mediation model mediate relationship between adult psychosis. Method A...
Visual hallucinations (VH) are more common than previously thought and linked to higher levels of distress disability in people with a psychotic illness. Despite this, scant attention has been given VHs the clinical literature, few therapy case series cognitive behavioural (CBT) published date have not demonstrated reliable change. In other areas research, problematic mental imagery found be strongly related negative affect psychological disorders linguistic thinking, focused techniques...
Objectives This study investigated the therapeutic alliance ( TA ) between clients and therapists involved in a telephone‐based cognitive behaviour therapy CBT oriented psychological intervention for individuals experiencing psychosis. Design The telephone recovery‐focused with use of self‐help guide group co‐facilitated by colleagues personal experience It was delivered as part Participant Preference Trial. Methods Twenty‐one client/therapist dyads were examined within this study. In...
Abstract Background: Many people with psychosis experience persecutory delusions and report negative schematic beliefs intrusive mental images which may be maintaining factors for psychotic symptoms. Aims: This study examined the feasibility acceptability of a new psychological therapy targeting schemas (iMAPS therapy). Method: The used randomised multiple baseline design. Participants first episode were using design 2–5 assessments. Six sessions therapy, consisting combination imagery...
Technological advances in healthcare have shown promise when delivering interventions for mental health problems such as psychosis. The aim of this project is to develop a mobile phone intervention people with psychosis and conduct feasibility study the TechCare App.The App will assess participant's symptoms respond personalised guided self-help-based psychological exploring acceptability. recruit 16 service users 8-10 professionals from Lancashire Care NHS Foundation Trust Early...
BackgroundCognitive models of psychosis suggest that negative schema confer vulnerability to and maintain psychotic symptoms. However, few studies have investigated among individuals with symptoms, research has yet investigate associations between early maladaptive social functioning distress. The current preliminary study aimed these issues.MethodsA cross‐sectional design was utilised. Participants experience (n = 20) completed questionnaires measuring schema, functioning, global...
The experience of psychosis and its sequelae (including treatment experiences) can be traumatic affect feelings safety security. Until relatively recently, trauma therapy has been avoided with populations due to concerns about additional harm. Intervention-based research is growing, but focus on psychosis-related limited. Engendering psychological may support engagement trauma-focused therapy, for which attachment theory provides a strong foundation. Imagery enhance felt security an...
Generalised anxiety disorder affects about 4.4% of the adult population in England.1 It is characterised by worry and apprehension. Worries are typically widespread, involving everyday issues a shifting focus concern; person with this finds it difficult to control their worries.2 3 Like other disorders, often chronic if untreated,2 associated substantial disability equivalent physical health problems such as arthritis diabetes.4 People generalised have high levels service use (visits general...
Objectives The aim of the project was to examine acceptability and feasibility a mobile phone application-based intervention ‘TechCare’, for individuals with psychosis in North West England. main objectives were determine whether appropriate could be identified recruited study TechCare App would an acceptable psychosis. Methods This mixed methods study, consisting test-run evaluation intervention. Setting Early Intervention Services (EIS) psychosis, within NHS Trust Participants Sixteen...
Cognitive behavioural treatments are recommended for people with psychosis. Core beliefs regarding the self and others a key part of models underpinning cognitive therapy but detailed understanding these putative in psychosis limited. A greater mechanisms is necessary to improve refine treatments.This study utilized qualitative approach explore core schematic (strongly held positive negative about others) their relation hallucinations delusions.Twenty individuals participated individual...
Irritable bowel syndrome (IBS) is a common functional disorder that has considerable impact on patient quality of life and substantial societal health care resource costs. Current treatments are often ineffective. Tricyclic antidepressants have shown promise in secondary populations but their effectiveness primary setting remains unclear.ATLANTIS randomised, multi-centre, parallel-group, two-arm, double-blind, placebo-controlled trial low-dose amitriptyline as second-line treatment for IBS...
Background: Clinical guidelines recommend cognitive behaviour therapy (CBT) for people with psychosis, however, implementation is poor and not everyone wishes to engage therapy. Understanding service user (SU) preferences receiving such treatments a priority services.Aims: To explore SU outcomes of different methods delivering CBT psychosis.Method: SUs experiencing psychosis could choose between treatment as usual (TAU); TAU plus telephone-delivered self-help, recovery manual (TS); high...
Abstract Objectives To examine the feasibility and acceptability of a novel telehealth ( video‐conferencing software telephone calls ) imagery‐based therapeutic intervention for people experiencing persecutory delusions. Utilising multiple baseline case series design exploring imagery‐focused therapy psychosis (iMAPS). Design A non‐concurrent A‐B was used. Methods Participants delusions self‐reporting or schizophrenia‐spectrum diagnosis were recruited through online adverts. On completion...