A5064526595- Systemic Lupus Erythematosus Research
- Platelet Disorders and Treatments
- Blood Coagulation and Thrombosis Mechanisms
- Hemophilia Treatment and Research
- Venous Thromboembolism Diagnosis and Management
- Blood disorders and treatments
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Heparin-Induced Thrombocytopenia and Thrombosis
- Atrial Fibrillation Management and Outcomes
- Blood properties and coagulation
- Monoclonal and Polyclonal Antibodies Research
- Protease and Inhibitor Mechanisms
- Hematopoietic Stem Cell Transplantation
- Cell Adhesion Molecules Research
- Vitamin K Research Studies
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Hemostasis and retained surgical items
- Sepsis Diagnosis and Treatment
- Trauma and Emergency Care Studies
- Chronic Myeloid Leukemia Treatments
- Phagocytosis and Immune Regulation
- Antiplatelet Therapy and Cardiovascular Diseases
- Atherosclerosis and Cardiovascular Diseases
- Acute Myeloid Leukemia Research
Sapporo University
2023-2025
Health Sciences University of Hokkaido
2014-2024
University of Health Sciences
2024
Chubu National Hospital
2020-2023
Ministry of Health Labour and Welfare
2017-2023
Collaborative Research Group
2023
The Japanese Society of Gastroenterological Surgery
2018
Creative Research Enterprises (United States)
2018
Hokkaido University
1990-2010
Okayama University
2010
Objective To clarify the association of autoantibodies against prothrombin with clinical manifestations antiphospholipid syndrome (APS) and presence lupus anticoagulant (LAC). Methods We examined 265 patients who visited our autoimmune disease clinic. IgG IgM antiprothrombin antibodies were tested by enzyme-linked immunosorbent assay (ELISA) as either antiphosphatidylserine–prothrombin complex (aPS/PT) or coated on irradiated ELISA plates (as antigen) (aPT). IgG, IgM, IgA anticardiolipin...
Trauma-induced tissue factor (TF) release into the systemic circulation is considered to play an important role in development of disseminated intravascular coagulation (DIC) immediately after severe trauma. However, relationship between TF and hyperfibrinolysis, especially fibrinogenolysis, has been unclear. A total 18 rats were divided three groups: (a) control group was infused with normal saline; (b) low-dose 4 U/kg TF; (c) high-dose 16 TF. Arterial blood drawn 2 h start infusion. At...
It was the study objective to evaluate whether low levels of plasma protein S (PS) activity, free PS, C (PC) activity and coagulation factor XII (FXII) during early pregnancy are related adverse outcomes. Peripheral blood samples were obtained at 8-14 gestational weeks (GW) from a consecutive series 1,220 women. The PS PC FXII measured. Cut-off values defined as < 1st, 5th, 10th percentiles 933 women whose pregnancies ended in normal deliveries without complications. percentile yielded risks...
Objective To clarify mechanisms of the thrombosis associated with anticardiolipin antibodies (aCL), we examined effects on activated protein C (APC) monoclonal aCL and β2-glycoprotein I (β2GPI), which is required for formation epitopes aCL. Methods We developed chromogenic assay, in degradation coagulation factor Va by APC reflected reduced generation thrombin from prothrombin, using soybean trypsin inhibitor to inhibit APC. activities were measured presence absence 3.4 μM β2GPI and/or 2.5...
Abstract Objective Antibodies to prothrombin (APTs) and β 2 ‐glycoprotein I are the major autoantibodies responsible for lupus anticoagulant (LAC) activity. APTs comprise antibodies against alone as well phosphatidylserine/prothrombin complex (anti‐PS/PT), latter being highly associated with antiphospholipid syndrome (APS). The effect of anti‐PS/PT on thrombin generation has not been elucidated, paradoxical LAC (an in vitro, but a procoagulant vivo) remains an enigma. purpose this study was...
Summary. β2‐glycoprotein I (β2GPI) bears the epitope(s) for autoimmune anticardiolipin antibodies (aCL) frequently present in patients with antiphospholipid syndrome (APS). β2GPI is involved coagulation and fibrinolytic systems, including inhibition of contact activation. Coagulation factor XII an initiator intrinsic also fibrinolysis. We investigated effect aCL (= anti‐β2GPI antibodies), regarding fibrinolysis using monoclonal derived from a patient APS or NZW/BXSB‐F1 mouse. developed...
Abstract The course of the differentiation and proliferation human erythroid burst‐forming units (BFU‐E) to colony‐forming (CFU‐E) was directly investigated using a combination highly purified BFU‐E, liquid culture system, following clonal assay. Highly blood BFU‐E with purity 45–79% were cultured in medium recombinant erythropoietin (rEP) interleukin‐3 (rlL‐3) generate more differentiated progenitors. cells collected daily for investigating morphology, increment number clonality. Ninety...
The case history is presented of a patient with Trousseau's syndrome in which tissue factor originating from lung cancer appeared responsible for recurrent DVT/PE. This thought to be the first such reported.
Venous thromboembolism (VTE) incidence is rising rapidly in Japan with lifestyle westernization and aging. Deficiency of protein S, an important blood coagulation regulator, a risk factor for VTE. Protein S deficiency prevalence Asians approximately 10 times that Caucasians type II deficiency, associated the Tokushima mutation (K155E), quite high Japan. However, currently available methods measuring are not precise enough detection this deficiency. We developed novel assay system...