A5073382805- Animal Disease Management and Epidemiology
- Influenza Virus Research Studies
- Vector-Borne Animal Diseases
- Viral gastroenteritis research and epidemiology
- Viral Infections and Vectors
- Respiratory viral infections research
- Viral Infections and Immunology Research
- Animal Virus Infections Studies
- Immune Response and Inflammation
- Vector-borne infectious diseases
- Tuberculosis Research and Epidemiology
- Microbial infections and disease research
- interferon and immune responses
- Mycobacterium research and diagnosis
- Virus-based gene therapy research
- Leptospirosis research and findings
- Veterinary medicine and infectious diseases
- Virology and Viral Diseases
- Infectious Diseases and Tuberculosis
- Prion Diseases and Protein Misfolding
- Rabies epidemiology and control
- Humic Substances and Bio-Organic Studies
- Viral Infectious Diseases and Gene Expression in Insects
- Bacteriophages and microbial interactions
- Insect and Pesticide Research
Hokkaido University
2016-2025
Health Sciences University of Hokkaido
2022-2025
Institut de Recherche Vaccinale
2024
Hokkaido University of Science
2024
Sapporo University
2024
Matrix Research (United States)
2019
Sapporo Science Center
2018
Safoso (Switzerland)
2013
University of the Ryukyus University Hospital
2009
Since September 2018, nearly 900 notifications of classical swine fever (CSF) have been reported in Gifu Prefecture (Japan) affecting domestic pig and wild boar by the end August 2019. To determine epidemiological characteristics its spread, a spatio-temporal analysis was performed using actual field data on current epidemic. The spatial study, based standard deviational ellipses official CSF notifications, showed that disease likely spread to northeast part prefecture. A maximum significant...
Many high pathogenicity avian influenza (HPAI) cases in wild birds due to H5N1 HPAI virus (HPAIV) infection were reported northern Japan the winter of 2021–2022. To investigate epidemiology HPAIVs brought from surrounding areas, a genetic analysis H5 isolated was performed, and HPAIV chickens assessed by experimental infection. Based on hemagglutinin gene, pathogenic viruses detected as well one Sakhalin, eastern part Russia, classified into same subgroup prevalent Europe season but distinct...
High pathogenicity avian influenza (HPAI) has impacted poultry and wild birds globally. The number of H5 HPAI virus (HPAIV) infection cases in Hokkaido (Northern Japan) was high the last two seasons, contributing to spillover resident poultry. Therefore, HPAIVs mammals winter 2022–2023 2023–2024 were monitored viruses phylogenetically, antigenically, pathogenetically characterized. Thirty HPAIV isolates subtyped pathotyped by sequencing hemagglutinin (HA) gene viruses. Phylogenetic analysis...
Abstract Spotted fever group (SFG) rickettsiae are obligate intracellular Gram-negative bacteria mainly associated with ticks. In Japan, several hundred cases of Japanese spotted fever, caused by Rickettsia japonica , reported annually. Other species also known to exist in ixodid ticks; however, their phylogenetic position and pathogenic potential poorly understood. We conducted a nationwide cross-sectional survey on questing ticks understand the overall diversity SFG Japan. Out 2,189...
Global dispersion of high pathogenicity avian influenza (HPAI), especially that caused by H5 clade 2.3.4.4, has threatened poultry industries and, potentially, human health. An HPAI virus, A/northern pintail/Hokkaido/M13/2020 (H5N8) (NP/Hok/20) belonging to 2.3.4.4b, was isolated from a fecal sample collected at lake in Hokkaido, Japan where migratory birds rested, October 2020. In the phylogenetic trees all eight gene segments, NP/Hok/20 fell into cluster European isolates 2020, but...
ABSTRACT Although current H5N1 highly pathogenic avian influenza viruses (HPAIV) are inefficiently transmitted to humans, infected individuals can suffer from severe disease, often progressing rapidly acute respiratory distress syndrome and multiorgan failure. This is in contrast with the situation human viruses, which immunocompetent usually cause only a disease less aggressive than that observed viruses. While biological basis of inefficient transmission well documented, mechanisms by...
The prolongation of the classic swine fever (CSF) outbreak in Japan 2018 was highly associated with persistence and widespread CSF virus (CSFV) wild boar population. To investigate dynamics boar, spatiotemporal analyses were performed. positive rate CSFV fluctuated dramatically from March to June 2019, but finally stabilized at approximately 10%. Euclidean distance initial notified farm farthest infected day constantly increased over time since except cases reported Gunma Saitama...
Classical swine fever has been spreading across the country since its re-emergence in Japan 2018. Gifu Prefecture working diligently to control disease through oral vaccine dissemination targeting wild boars. Although vaccines were sprayed at 14,000 locations between 2019 and 2020, ingestion by boars was only confirmed 30% of locations. Here, we predicted rate each point Random Forest modeling based on data created prediction surfaces for probability boar using spatial interpolation...
Background It is essential to consider a practical antibody test successfully implement marker vaccines and validate vaccination efficacy against classical swine fever virus (CSFV). The should include serological assay, combined with tool for differentiating infected from vaccinated animals (DIVA). immunochromatographic strip (ICS) has been exclusively designed detecting CSFV E2 antibodies while lacking in E rns antibodies, which can be employed satisfy DIVA strategy. This study developed...
Bovine viral diarrhea (BVD) is caused by the BVD virus (BVDV) and has been reported worldwide in cattle. To estimate BVDV circulation among cattle where few cases were southern Japan, 1910 serum samples collected from 35 farms without a outbreak investigated to detect antibodies against BVDV-1 BVDV-2 using an indicator with cytopathogenic effect luciferase gene, respectively. Neutralizing detected more frequently 18 vaccinated than 17 nonvaccinated farms. In farms, 9.6%, 1.8%, 13.8% of...
Classical swine fever virus (CSFV) is genetically categorized into three genotypes. A live-attenuated vaccine strain GPE-, currently used in Japan, belongs to genotype 1 and distinct from the field strains circulating which belong 2. This study aimed understand antigenicity of recent isolates Japan develop new candidates that antigenically match strains. The serum samples 20 pigs vaccinated with GPE- were subjected a neutralizing test (SNT) using one strains, CSFV/wb/Jpn-Mie/P96/2019...
ABSTRACT Influenza A viruses with fewer amino acids in the neuraminidase (NA) stalk domain are primarily isolated from chickens rather than wild ducks, indicating that a shortened NA is considered an adaptation marker of avian influenza (AIVs) to chickens. Experimental passages H7N7 nonpathogenic AIV (rgVac2-P0) resulted highly pathogenic variant (Vac2-P3L4) 34-amino-acid deletion stalk, encompassing five potential N -glycosylation sites. To investigate how acid truncation and...
Vitamin D is a fat-soluble vitamin that metabolized by the liver into 25-hydroxyvitamin [25(OH)D] and then kidney 1,25-dihydroxyvitamin [1,25(OH)2D], which activates receptor expressed in various cells, including immune for an overall immunostimulatory effect. Here, to investigate whether oral supplementation of D3 [25(OH)D3], major form metabolite 25(OH)D, has prophylactic effect on influenza A virus infection, mice were fed diet containing high dose 25(OH)D3 challenged with virus. In lungs...
Control of infectious diseases in wildlife is often considered challenging due to the limited availability information. Some can also affect livestock, posing significant problems for animal farming industry. In Japan, classical swine fever (CSF) reemerged September 2018. Given commercial vaccines, control measures mainly involve vaccination domestic pigs and distribution oral vaccines wild boars. Despite these efforts, disease continues spread, primarily This transmission further...
Highly pathogenic avian influenza viruses (HPAIVs) cause lethal infection in chickens. Severe cases of HPAIV infections have been also reported mammals, including humans. In both mammals and birds, the relationship between host cytokine response to with HPAIVs outcome has not well understood. present study, highly A/turkey/Italy/4580/1999 (H7N1) (Ty/Italy) A/chicken/Netherlands/2586/2003 (H7N7) (Ck/NL) low virus (LPAIV) A/chicken/Ibaraki/1/2005 (H5N2) (Ck/Ibaraki) were intranasally...