A5051907657- Endometrial and Cervical Cancer Treatments
- Advanced Radiotherapy Techniques
- Management of metastatic bone disease
- Colorectal and Anal Carcinomas
- Cervical Cancer and HPV Research
- Ovarian cancer diagnosis and treatment
- Lung Cancer Diagnosis and Treatment
- Radiation Therapy and Dosimetry
- Lung Cancer Treatments and Mutations
- Medical Imaging Techniques and Applications
- Head and Neck Cancer Studies
- Kidney Stones and Urolithiasis Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Lung Cancer Research Studies
- Cancer Immunotherapy and Biomarkers
- Bladder and Urothelial Cancer Treatments
- Effects of Radiation Exposure
- Uterine Myomas and Treatments
- Sarcoma Diagnosis and Treatment
- Biomedical Research and Pathophysiology
- Radiation Detection and Scintillator Technologies
- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Prostate Cancer Treatment and Research
- Advanced Chemical Physics Studies
Saitama Medical University
2015-2024
Yokohama City University
2009-2022
Yokohama City University Hospital
2022
Tokyo Institute of Technology
2018
Saitama International Medical Center
2012-2016
National Institutes for Quantum Science and Technology
2004-2013
Social Insurance Saitama Chuo Hospital
2009-2011
Gunma University
1992-2009
Nagoya University
2007
Yamaguchi University
2005
In 1994 a Phase I/II clinical study on carbon ion radiotherapy was begun at NIRS using HIMAC, which then the world's only heavy accelerator complex dedicated to medical use in hospital environment. Among several types of species, we have chosen ions for cancer therapy because they had most optimal properties terms possessing, both physically and biologically, effective dose-localization body. The purpose investigate efficacy against variety tumors as well develop techniques delivering an...
Abstract BACKGROUND The authors performed a long‐term follow‐up study to evaluate the efficacy and late toxicity of high‐dose rate intracavitary brachytherapy (HDR‐ICBT) for cervical carcinoma. METHODS From 1968 1986, 1148 patients with Stage IB IVB squamous cell carcinoma cervix (staging was according International Federation Gynecology Obstetrics) were treated combination external beam radiotherapy (EBRT) HDR‐ICBT. For early‐stage disease, 20 gray (Gy) EBRT delivered whole pelvis, followed...
Abstract Purpose: The purpose is to evaluate the efficacy and toxicity of carbon ion radiotherapy for unresectable sacral chordomas. Experimental Design: We performed a retrospective analysis 30 patients with chordomas treated at Heavy Ion Medical Accelerator in Chiba, Japan. Twenty-three presented no prior treatment, remaining 7 had locally recurrent disease following previous surgical resection. median clinical target volume was 546 cm3. applied dose ranged from 52.8 73.6 GyE (gray...
Carbon-ion radiotherapy (C-ion RT) possesses physical and biological advantages. It was started at NIRS in 1994 using the Heavy Ion Medical Accelerator Chiba (HIMAC); since then more than 50 protocol studies have been conducted on almost 4000 patients with a variety of tumors. Clinical experiences demonstrated that C-ion RT is effective such regions as head neck, skull base, lung, liver, prostate, bone soft tissues, pelvic recurrence rectal cancer, well for histological types including...
Our purpose was to develop recommendations for contouring the computed tomography (CT)-based high-risk clinical target volume (CTVHR) 3D image-guided brachytherapy (3D-IGBT) cervical cancer. A 15-member Japanese Radiation Oncology Study Group (JROSG) committee with expertise in gynecological radiation oncology initiated guideline development CT-based CTVHR (based on a comprehensive literature review as well experience) July 2014. Extensive discussions occurred during four face-to-face...
Background It remains unclear why radiation clinically provides a synergistic effect when combined with immune checkpoint inhibitors such as nivolumab. The purpose of our study was to retrospectively evaluate whether the therapeutic efficacy nivolumab is improved result history radiotherapy (RT) in patients previously treated advanced non‐small cell lung cancer (NSCLC). Methods From February 2016 December 2017, 124 consecutive were administered for pretreated NSCLC. divided into RT and...
Background Chemoradiotherapy followed by durvalumab is the standard treatment for patients with local advanced non‐small cell lung cancer (NSCLC). There a real‐world data about management of adverse events, such as pneumonitis, according to different institutions. Here, we present experience regarding events after initiation daily practice. Methods From July 2018 August 2019, 41 locally NSCLC, who underwent chemoradiotherapy durvalumab, were retrospectively analyzed in study using our...
This study demonstrates the clinical usefulness of image-guided fractionated stereotactic radiosurgery with CyberKnife system. Twenty-one patients pituitary adenomas received CyberKnife, and were followed up for more than 18 months. The consisted 14 non-functioning adenomas, 3 prolactinomas, 2 acromegaly, ACTH-producing tumors. In 20 cases, was performed. change in tumor volume, visual acuity, hormonal function, complications by this therapy analyzed each case. volume tumors ranged from 0.2...
BACKGROUND This study sought to evaluate the toxicity and efficacy of carbon ion radiotherapy (C‐ion RT) for locally advanced adenocarcinoma uterine cervix in a phase 1/2 clinical trial. METHODS The treatment consisted whole‐pelvic irradiation 36.0 gray equivalents (GyE) 12 fractions local boost with dose escalation from 26.4 38.4 GyE 8 fractions. was performed careful observation acute normal tissue responses. Total cervical tumor 62.4 74.4 20 RESULTS Between April 1998 February 2010, 58...
Abstract Cancer cells often develop drug resistance. In cisplatin-resistant HeLa cisR cells, fibroblast growth factor 13 (FGF13/FHF2) gene and protein expression was strongly upregulated intracellular platinum concentrations were kept low. When the FGF13 suppressed, both cells' resistance to drugs their ability keep low abolished. Overexpression of in parent led greater cisplatin reductions concentration. These also showed increased copper. preoperative cervical cancer biopsy samples from...
The present study evaluated whether differences in the type of radiotherapy, disease stage, and self-esteem influence psychological distress quality life (QOL) among cervical cancer survivors. Sixty survivors, after chemoradiotherapy, or postoperative radiotherapy for cancer, participated study. participants were asked to complete questionnaires during follow-up visits. included Japanese version Hospital Anxiety Depression Scale, Functional Assessment Cancer Therapy-General, Rosenberg...
This study evaluated the efficacy of computed tomography (CT)-based three-dimensional (3D) dose-volume parameters rectum as predictor for late rectal complication (LRC) in cervical cancer patients treated with radiotherapy alone. Eighty-four a combination external and high-dose-rate intracavitary brachytherapy between January 2000 December 2004 were retrospectively analyzed. Brachytherapy was prescribed standard 2D planning. Patients underwent pelvic CT at brachytherapy. The wall contoured...
Abstract We conducted a phase 1/2 study to evaluate the efficacy and safety of carbon ion radiotherapy (C‐ion RT ) with concurrent chemotherapy for locally advanced uterine cervical adenocarcinoma. Thirty‐three patients were enrolled between April 2010 March 2014. Treatment consisted C‐ion weekly cisplatin at dose 40 mg/m 2 . In 1 component, total was escalated from 68.0 Gy (relative biological effectiveness [ RBE ]) 74.4 ( determine maximum tolerated evaluated using determined in component....
We investigated the incidence and dose-volume relationships of radiation pneumonitis (RP) after concurrent chemoradiotherapy (CCRT) followed by durvalumab for locally advanced non-small-cell lung cancer (LA-NSCLC).We retrospectively analyzed records 36 patients with LA-NSCLC who underwent CCRT durvalumab. Incidence RP was correlations clinical factors parameters in radiotherapy.All received 60 Gy 30 fractions radiotherapy chemotherapy. Over a median follow-up period 7 months, grade ≥2 36%...
This study aimed to provide accurate dose distribution profiles of radiotherapy for cervical cancer when treated with the central shielding technique by analysing composite 3D EQD2 external beam (EBRT) plus intracavitary brachytherapy (ICBT). On a phantom, four patterns combinations whole pelvis irradiation (WP) (4 fields), (CS) [anterior–posterior/posterior–anterior (AP-PA width 3 or 4 cm] and ICBT using Point-A prescription were created: 30 Gy/15 fractions + 20 Gy/10 24 Gy/4 [Plan (30...
The purpose of the study was to evaluate feasibility deformable image registration (DIR) in assessing cumulative dose distributions combination external beam radiotherapy (EBRT) and fractionated intracavitary brachytherapy (ICBT) for cervical cancer.Three-dimensional data sets five consecutive patients were used. treatment plan consisted whole pelvic EBRT (total dose: 45 Gy 25 fractions) combined with computed tomography (CT)-based high-dose rate ICBT (≥24 4 fractions high risk clinical...