A5002468717- Vascular Malformations Diagnosis and Treatment
- Spine and Intervertebral Disc Pathology
- Intracranial Aneurysms: Treatment and Complications
- Glioma Diagnosis and Treatment
- Spinal Fractures and Fixation Techniques
- Meningioma and schwannoma management
- Cervical and Thoracic Myelopathy
- Acute Ischemic Stroke Management
- Pituitary Gland Disorders and Treatments
- Neurosurgical Procedures and Complications
- Intraoperative Neuromonitoring and Anesthetic Effects
- Brain Metastases and Treatment
- Spinal Hematomas and Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebrovascular and Carotid Artery Diseases
- Head and Neck Surgical Oncology
- Cerebral Venous Sinus Thrombosis
- Cerebrospinal fluid and hydrocephalus
- Spinal Dysraphism and Malformations
- Management of metastatic bone disease
- Lung Cancer Treatments and Mutations
- Anesthesia and Pain Management
- Medical Imaging and Pathology Studies
- Adrenal and Paraganglionic Tumors
- Intracerebral and Subarachnoid Hemorrhage Research
Nara Medical University
2016-2025
Hyogo University
2025
Hyogo Medical University
2024
The University of Tokyo
2023
Nara Medical University Hospital
2017-2022
Hiroshima University
1992-2017
Shimane University
2017
Fujieda Municipal General Hospital
2011-2016
Kobe University
2000-2014
National Cancer Institute
1993
Natural killer (NK) cells are considered potential antitumor effector cells. The aim of this study was to establish a novel type chimeric antigen receptor (CAR) NK cell line (CAR-KHYG-1) specific for epidermal growth factor variant III (EGFRvIII)-expressing tumors and investigate the anti-tumor activity EGFRvIII-specific-CAR-KHYG-1 (EvCAR-KHYG-1).EvCAR-KHYG-1 established by self-inactivated lentiviral-based transduction EvCAR gene magnetic bead-based purification EvCAR-expressing effects...
To evaluate cervical facet joint degeneration using a newly developed classification, investigate its prevalence and relationship with degenerative spondylolisthesis, clarify clinical significance in patients myelopathy (DCM).This study included 145 consecutive DCM who underwent surgical treatment. Clinical variables radiological findings were analyzed. A new 6-grade computed tomography (CT) classification for was adapted, evaluated by categorizing the joints into those at responsible...
ABSTRACT This study aimed to evaluate the prognostic value of pre-treatment blood cell counts in patients with brain metastasis (BM) from non-small lung cancer (NSCLC) who were treated using linear accelerator (linac)-based stereotactic radiosurgery (SRS) and fractionated radiotherapy (fSRT) a micro-multileaf collimator. Between January 2011 November 2022, 271 consecutive underwent linac-based SRS/fSRT for BM NSCLC. Thirty insufficient test data during this period excluded analysis....
BACKGROUND: The increasing number of neurosurgical procedures for elderly patients and the development skull base neurosurgery have increased interest in cerebral venous injury that might occur a setting. Brain-derived neurotrophic factor (BDNF) may neuroprotective effects against ischemia. OBJECTIVE: To investigate intraventricular BDNF infusion on infarct size, suppression apoptosis, regional blood flow (rCBF) ischemic lesions rat 2-vein occlusion model. METHODS: Thirty-three male Wistar...
<b><i>Background:</i></b> Hyponatremia is a common complication occurring in one third of patients after subarachnoid hemorrhage (SAH). One mechanism that likely mediates the development hyponatremia SAH cerebral salt wasting syndrome (CSWS), which induces natriuresis and reduces total blood volume, resulting risk symptomatic vasospasm (SVS). The mineral corticoid fludrocortisone acetate enhances sodium reabsorption renal distal tubules may help prevent post-SAH...
Our objective was to correlate vascular endothelial growth factor (VEGF) genetic polymorphisms with the risk of bronchopulmonary dysplasia (BPD) development in premature newborns. Fifty-five newborns BPD (BPD: median gestational age [GA]: 27 weeks, birthweight [BW]: 786 g) and 42 without (non-BPD: GA: 29 BW: 1,165 g), who were born at <32 weeks admitted Kobe University Hospital, included. defined as oxygen dependency 36 postmenstrual age. Genomic DNA extracted from umbilical cord, cord...
Transforaminal lumbar interbody fusion (TLIF) procedure is widely used, but the surgical indications for TLIF in elderly patients remain controversial because of potential risks such as inferior bone quality and higher rate postoperative complications. Clinical efficacy operative risk are unclear. This study investigated clinical effect safety degenerative spondylolisthesis with radiculopathy or neurogenic claudication aged 70 years older. The records were retrospectively reviewed 35...
The authors report the rare case of a 58-year-old man with segmental arterial mediolysis (SAM) associated intracranial and intraabdominal aneurysms, who suffered subarachnoid hemorrhage (SAH) due to rupture an aneurysm. This disease primarily involves system, resulting in retroperitoneal most cases. patient presented severe headache vomiting. CT scans head revealed SAH. Cerebral angiography 3 aneurysms: 1 right distal anterior cerebral artery (ACA), portion A(1) segment ACA, left vertebral...
A 39-year-old man presented with an extremely rare discal cyst at the L3-4 level manifesting as a left L4 radiculopathy. Two months after onset, he suffered right radiculopathy new lumbar disc protrusion. Five medical treatment, patient's symptoms improved, and showed complete regression on magnetic resonance imaging. Most cases of are surgically treated, only two previous spontaneous regression. The present case suggests clinical radiological recovery symptomatic can be obtained by...
Periprocedural lipid core plaque (LCP) has been detected in carotid arteries assessed by catheter-based near-infrared spectroscopy (NIRS). High LCP is associated with cerebral embolism after artery stenting (CAS) using a first-generation stent. We aimed to evaluate whether dual-layered stents reduce embolic infarcts patients high and change of signal as NIRS during CAS.Participants comprised 210 consecutive undergoing CAS. The study was divided into two distinct periods, closed-cell used the...