As part of the search for naturally derived α‐glucosidase inhibitors, chemical components isolated from safflower seed ( Carthamus tinctorius L.) were evaluated. The compounds active as inhibitors serotonin derivatives (e.g. N‐p ‐coumaroyl (1) and N ‐feruloyl (2)). These showed a potent inhibitory activity, 50% concentration (IC 50 ) values calculated 47.2 µ m 99.8 (2) while that reference drugs acarbose 1‐deoxynojirimycin evaluated 907.5 278.0 , respectively. Regarding structure derivative,...

OBJECT Spinal meningioma and schwannoma are the most common spinal intradural extramedullary tumors, differentiation of these 2 tumors by CT MRI has been a matter debate. The purpose this article is to present case series meningiomas showing unique imaging features: combination fan-shaped cord streak in tumor. authors termed former feature "ginkgo leaf sign" evaluated its diagnostic value. METHODS 7 cases having ginkgo sign. Thirty arising lateral or ventrolateral were studied evaluate value...

Objective: The treatment of osteoporotic vertebral compression fractures (OVCFs) is based on their severity; however, an efficient prediction tool lacking. We aimed to evaluate the validity fracture classification (OF classification) and scoring system score) in predicting strategy for patients with OVCF, defined according Japanese criteria.Methods: retrospectively investigated 487 consecutive diagnosed body between January 2018 December 2022. Only fresh episode during study period were...

✓ Vertebral artery (VA) occlusion by rotation of the head is uncommon, but can result from mechanical compression artery, trauma, or atlantoaxial instability. Occipital bone anomalies rarely cause rotational VA occlusion, and patients with nontraumatic intermittent usually present compromised vertebrobasilar flow. A 34-year-old man suffered three embolic strokes in system within 2 months. Magnetic resonance imaging demonstrated multiple infarcts territory. Angiography performed immediately...

Transforaminal lumbar interbody fusion (TLIF) is widely accepted for the treatment of arthrodesis. However, exact characteristics TLIF depend on number, location, shape, or materials implants, and type posterior instrument. Clinical biomechanical each procedure are still unclear. The present study investigated clinical radiological improvements after single level asymmetrical TLIF, in which a box-shaped spacer was obliquely inserted into intervertebral space, degenerative spondylolisthesis...

Background and Objectives: Condoliase, a chondroitin sulfate ABC endolyase, is novel minimally invasive chemonucleolytic drug for lumbar disc herniation. Despite the growing number of treatments herniation, predicting factors poor outcomes following treatment remain unclear. The aim this study was to determine predictive unsuccessful clinical outcome condoliase therapy. Material Methods: We performed retrospective single-center analysis 101 patients who underwent chemonucleolysis with from...

Transforaminal lumbar interbody fusion (TLIF) procedure is widely used, but the surgical indications for TLIF in elderly patients remain controversial because of potential risks such as inferior bone quality and higher rate postoperative complications. Clinical efficacy operative risk are unclear. This study investigated clinical effect safety degenerative spondylolisthesis with radiculopathy or neurogenic claudication aged 70 years older. The records were retrospectively reviewed 35...

The clinical outcome and resumption of work were investigated in 21 patients with lumbar discogenic pain (15 males 6 females, mean age 37.2 years), who failed to respond intensive conservative therapy, treated by transforaminal interbody fusion (TLIF) augmented the pedicle screw system from January 2005 December 2007. Perioperative assessment was performed using modified Japanese Orthopaedic Association (mJOA) score, Oswestry Disability Index, visual analogue scale (VAS). Type occupation...

The impact of adjuvant radiotherapy on overall survival (OS) and progression-free (PFS) patients with grade II spinal cord astrocytomas remains controversial. Additionally, the relationship between progression clinical deterioration after has not been well investigated.This study included 53 intramedullary treated by either subtotal, partial resection or open biopsy. Their performance status was assessed immediately before operation 1, 6, 12, 24, 60 months surgery Karnofsky Performance Scale...

A 39-year-old man presented with an extremely rare discal cyst at the L3-4 level manifesting as a left L4 radiculopathy. Two months after onset, he suffered right radiculopathy new lumbar disc protrusion. Five medical treatment, patient's symptoms improved, and showed complete regression on magnetic resonance imaging. Most cases of are surgically treated, only two previous spontaneous regression. The present case suggests clinical radiological recovery symptomatic can be obtained by...

We describe 5 cases of osteochondroma (OC) originating from lumbosacral spine which caused radiculopathy. Four originated the lumbar spine; all L4 inferior articular process and presented L5 radiculopathy, other one case sacrum; S1 superior In cases, definitive diagnosis was made with histopathological findings; typical cartilaginous capping confirmed. The functional recovery completed in cases. As for imaging study, post myelography computed tomography revealed most diagnostic tool...

Abstract OBJECTIVE AND IMPORTANCE Cervical myelopathy induced by vascular compression is rare. We report a case caused bilateral persistence of the first intersegmental arteries (a vertebral artery anomaly). Myelopathy was successfully treated with decompression. CLINICAL PRESENTATION A 66-year-old woman presented gradually worsening paroxysmal neck and arm pain. Magnetic resonance imaging angiography demonstrated anomalous intradural courses both arteries, compressing dorsal aspect cervical...

Cervical spondylotic amyotrophy (CSA) is a relatively rare entity caused by cervical degenerative spinal diseases and characterized motor weakness accompanied remarkable muscle atrophy in the upper extremities without significant sensory deficits or spastic paraparesis lower extremities. Postoperative outcomes predictive prognostic factors vary among previous reports. In present report, we describe surgical results patients who were surgically treated for CSA literature review.In total, 33...

Spinal cord tumors, though rare, present formidable challenges in clinical management due to their intricate nature. Traditional treatment modalities like surgery, radiation therapy, and chemotherapy have been the mainstay for managing these tumors. However, despite significant advancements, persist, including limitations of surgical resection potential side effects associated with therapy. In response limitations, a wave innovative approaches is reshaping landscape spinal Advancements gene...

We measured cerebrospinal fluid flow velocity by use of cine phase contrast magnetic resonance imaging to quantitate the effectiveness surgical decompression in patients with cervical myelopathy.Forty-seven myelopathy attributable either spondylosis or ossification posterior longitudinal ligament were studied. Thirty-five underwent anterior and fusion; 12 others expansive laminoplasty. Patients examined preoperatively postoperatively a 1.5-T scanner pulse-gated sequence. Cerebrospinal...

A retrospective study.Our objectives were to determine the association between pathological changes of disc herniation and interval primary revision surgeries investigate frequency site dural laceration in surgeries.Among 382 patients who underwent microsurgical lumbar discectomy, we investigated 29 surgery analyze recurrent pathologies complications manner which can be more efficiently managed.Of patients, 22 had at same level site. The associated with compression factors classified into...