A5063751515- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Acute Ischemic Stroke Management
- Vascular Malformations Diagnosis and Treatment
- Intracranial Aneurysms: Treatment and Complications
- Neurosurgical Procedures and Complications
- Cervical and Thoracic Myelopathy
- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebrovascular and Carotid Artery Diseases
- Meningioma and schwannoma management
- Intracerebral and Subarachnoid Hemorrhage Research
- Cerebral Venous Sinus Thrombosis
- Infectious Diseases and Tuberculosis
- Barrier Structure and Function Studies
- Brain Metastases and Treatment
- Pelvic and Acetabular Injuries
- Glioma Diagnosis and Treatment
- Cerebrospinal fluid and hydrocephalus
- Spinal Hematomas and Complications
- Spinal Dysraphism and Malformations
- Osteomyelitis and Bone Disorders Research
- Bone Tumor Diagnosis and Treatments
- Medical Imaging and Analysis
- Head and Neck Surgical Oncology
- Long-Term Effects of COVID-19
Tokyo Women's Medical University
2016-2023
Osaka City General Hospital
2020-2022
Osaka Prefectural Medical Center
2020-2022
South Osaka Neurosurgical Hospital
2018-2020
Nara Medical University
2005-2018
National Cerebral and Cardiovascular Center
2018
Memorial Hospital of South Bend
2018
Hyogo Medical University
2018
National Kyushu Medical Center
2018
Clinical Research Institute
2018
Cerebral venous ischemia often induces severe brain edema. Vascular endothelial growth factor (VEGF), which angiogenesis, is also known as vascular permeability (VP) factor. The present study was undertaken to investigate whether the inhibition of VEGF could reduce edema formation and cerebral infarction (CVI) in a rat 2-vein occlusion (2-VO) model.We used 2-VO model 2 adjacent cortical veins were photochemically occluded. Male Wistar rats (n=25) divided into groups: one group treated with...
Increased mortality after stroke is associated with development of brain edema. The aim the present study was to examine contribution endothelial myosin light chain (MLC) phosphorylation hypoxia-induced blood-brain barrier (BBB) opening. Measurements trans-endothelial electrical resistance (TEER) were performed analyse BBB integrity in an vitro co-culture model (bovine microvascular cells (BEC) and rat astrocytes). Brain fluid content analysed rats induction using a two-vein occlusion model....
BACKGROUND: The increasing number of neurosurgical procedures for elderly patients and the development skull base neurosurgery have increased interest in cerebral venous injury that might occur a setting. Brain-derived neurotrophic factor (BDNF) may neuroprotective effects against ischemia. OBJECTIVE: To investigate intraventricular BDNF infusion on infarct size, suppression apoptosis, regional blood flow (rCBF) ischemic lesions rat 2-vein occlusion model. METHODS: Thirty-three male Wistar...
Thrombosis is a dynamic process, and thrombus undergoes physical biochemical changes that may alter its response to reperfusion therapy. This study assessed whether age influenced quality outcomes after mechanical thrombectomy for cerebral embolism.We retrospectively evaluated 185 stroke patients thrombi were collected during at three centers. Thrombi pathologically classified as fresh or older based on their granulocytes' nuclear morphology organization. Thrombus components quantified, the...
The incidence of spinal infections has increased in recent years, and vertebral osteomyelitis epidural abscess are issues great concern for spine surgeons. We retrospectively reviewed our cases treated by two-stage management abscess.The series consisted nine patients (five men four women); their ages ranged from 49 to 77 years (mean age, 60.6 yr). Coexisting medical conditions were diabetes mellitus one case long-term steroid intake another. Myelopathy or radicular pain was caused an all...
Use of instrumentation in spinal osteomyelitis remains controversial because the perceived risk persistent infection related to a devitalized graft and hardware. Particularly, limited information is available regarding long-term follow-up patients. We retrospectively reviewed use titanium mesh-bone composite after corpectomy pyogenic with minimum 3-year outcome.Four patients, two men women, cervical thoracic myelopathy caused by (two cases) epidural abscess, were treated. Their age ranged...
Endogenous neurogenesis can arise from a variety of physiological stimuli including exercise, learning, or “enriched environment” as well pathological conditions such ischemia, epilepsy cortical spreading depression. Whether all these use common trigger to set off endogenous is yet unclear. We hypothesized that depression (CSD) induces in the cerebral cortex and dentate gyrus after venous ischemia. Forty-two Wistar rats alternatively underwent sham operation (Sham), induction ten CSDs...
The incidence of remote cerebellar hemorrhage (RCH) in patients with a dural tear during spinal surgery is unclear. purpose this study was to determine the RCH and causative factors these patients.Two hundred thirty-nine underwent at our institution between March 2015 September 2016. Eleven needed suturing intraoperatively. All CT head on first postoperative day were categorized according whether they had or not. mean values for amount intraoperative bleeding, maximum perioperative blood...
Figure 1.Preoperative contrast-enhanced computed tomography showing the location of tumor.(A) 3D reconstruction (B) Sagittal (C) Axial view.
Central neurocytomas (CNs) are rare intraventricular tumors that well demarcated and display neuronal differentiation. This tumor type is most frequently diagnosed in young adults typically located at the septum pellucidum fornix, presents with intracranial hypertension due to obstructive hydrocephalus. Extraventricular (EVNs) biological histopathological characteristics similar CNs, but which arise from extraventricular parenchymal tissue (Giangaspero et al., 1997) Giangaspero al. (1997)...
Meticulous dissection to detach an aneurysm from perforating arteries and cranial nerves is often indispensable achieve complete neck clipping. We report surgical techniques for of unruptured using a pterional approach. Aneurysmal retraction with suction tube in appropriate direction considered facilitate aneurysms. For this purpose, our are summarized as follows: 1) Our “hand-resting” operating style. 2) The use short-size instruments securing meticulous aneurysm. 3) Dissection derived both...
Spine surgery is challenging in hemodialysis (HD)-dependent patients owing to their poor general condition. However, postoperative complications and the mortality survival rates have not been specifically evaluated a wide series. This study aimed elucidate rate cervical spine HD patients.This included 109 (70 men, 39 women) who had undergone between July 1996 May 2018. Based on radiological diagnosis, we divided them into destructive spondyloarthropathy (DSA) non-DSA groups. We investigated...
Objective: We encountered a rare case of steal phenomenon via the vertebral artery due to occlusion brachiocephalic that developed dissecting aneurysm in right and suffered subarachnoid hemorrhage.
Objective: We report a 73-year-old male in whom traumatic pseudoaneurysm of the middle meningeal artery (PMMA) increased during conservative treatment for subarachnoid hemorrhage, an acute subdural hematoma, and brain contusion, leading to intracerebral hemorrhage related its rupture.
Donut-shaped aneurysms are rare subtypes of partially thrombosed that can consist partial intraluminal thrombus induced by preferential circular laminar flow within the aneurysms. Intraluminal in a donut-shaped aneurysm might be fragile and cause thromboembolic complications during endovascular treatment because its pathogenesis supposedly differs from common caused intramural hemorrhage vasa vasorum proliferation. Here, we describe favorable outcome treating symptomatic, donut-shaped,...
ABSTRACT Objectives The purpose of this study was to examine the reproducibility vertical subluxation (VS) parameters using X-ray, computed tomography (CT), and tomosynthesis (TS) while comparing head-loading effects. Methods VS 26 patients (retrospective review) were evaluated. Using intra-class correlation coefficient, we statistically examined intra-rater inter-rater reliabilities parameters. Head-loaded -unloaded imagings compared a Wilcoxon signed-rank test. Results reliability TS CT...