A5101565272- Parkinson's Disease Mechanisms and Treatments
- Nuclear Receptors and Signaling
- Neurological disorders and treatments
- Neurological diseases and metabolism
- Oil and Gas Production Techniques
- Ferroptosis and cancer prognosis
- Immune cells in cancer
- Plant Molecular Biology Research
- Neurological Disease Mechanisms and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Electrocatalysts for Energy Conversion
- Electrochemical sensors and biosensors
- Genetics and Neurodevelopmental Disorders
- Advanced Chemical Sensor Technologies
- Analytical Chemistry and Chromatography
- Food Chemistry and Fat Analysis
- Cerebrospinal fluid and hydrocephalus
- Proteins in Food Systems
- RNA modifications and cancer
- Robotic Path Planning Algorithms
- Angiogenesis and VEGF in Cancer
- Marine and Offshore Engineering Studies
- AI and Big Data Applications
- Microencapsulation and Drying Processes
- Ginseng Biological Effects and Applications
Renmin Hospital of Wuhan University
2025
Wuhan University
2025
Soochow University
2025
China Pharmaceutical University
2025
Nanjing University of Chinese Medicine
2025
South China Normal University
2023-2024
Northwest A&F University
2023-2024
Qingdao University
2022-2023
Affiliated Hospital of Qingdao University
2022-2023
Mianyang Third People's Hospital
2023
Heme oxygenase-1 (HO-1) is a stress protein induced in response to variety of oxidative challenges. After treatment the hybrid septal cells SN 56 with beta-amyloid peptide (beta-AP1-40) or hydrogen peroxide (H2O2), we detected high levels reactive oxygen species, accompanied by significant elevation HO-1 expression. Levels increased and then decreased following cell loss. Pretreatment antisense oligonucleotides dramatically immunoreactivity significantly enhanced cytotoxicity beta-AP1-40...
Background Metastasis is the most pivotal cause of mortality in cancer patients. Immune tolerance plays a crucial role tumor progression and metastasis. Methods Findings In this study, we investigated potential roles mechanisms TLR2 signaling on metastasis mouse model intravenously injected B16 melanoma cells. Multiple subtypes TLRs were expressed cells several human cell lines; mediated invasive activity these High metastatic released more heat shock protein 60 than poor B16-F1 Importantly,...
Abstract Meningeal lymphatic vessels (mLVs) play a pivotal role in regulating metabolic waste from cerebrospinal fluid (CSF). However, the current limitations field of view and resolution existing imaging techniques impede understanding stereoscopic morphology dynamic behavior mLVs vivo. Here, we utilized dual-contrast functional photoacoustic microscopy to achieve wide-field intravital system, including glymphatic pathways. The based on opto-acoustic confocal features has depth capability...
Abstract Background Macrophages play an important role in the pathogenesis of ulcerative colitis (UC). We will explore effects sodium butyrate (SB) on macrophage function. Methods The targets butyric acid were identified using SwissTargetPrediction database and surface plasmon resonance (SPR). Limited proteolysis mass spectrometry (Lip-MS) was used to further investigate binding sites with its molecular docking employed simulate their modes. Macrophage polarization model established...
Glycyrrhiza uralensis Fisch. is a medicinal herb that can be added to food provide therapeutic effects and reduce the burden of medications. Herein, immunomodulatory polysaccharides (GPs) were verified illustrated by intervening immunocompromised rats treated with different doses GPs, which reflected for adjusting composition structure intestinal microbiota altering metabolic profile. The GPs exerted regulating microenvironment. In particular, could promote growth probiotic bacteria...
Abstract Dry eye disease (DED), the most prevalent ophthalmological condition worldwide, can cause severe ocular discomfort and even visual impairment. Effective yet safe therapeutics for DED are still highly demanded. Herein, considering important role of excessive reactive oxygen species (ROS) in triggering DED, an eye‐drop nano‐formulation catalase (CAT) self‐assembled with cysteine‐modified chitosan (CS‐Cys) is designed treatment. Upon administration CS‐Cys/CAT nanoparticles, CS‐Cys form...
Fluctuation and Noise LettersAccepted Papers No AccessIdentifying states of global oil gas market based on visibility graph embedding algorithmsNa Wei Wen-Jie XieNa Xie Search for more papers by this author https://doi.org/10.1142/S0219477525500270Cited by:0 (Source: Crossref) Next AboutFiguresReferencesRelatedDetailsPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsRecommend Library ShareShare onFacebookTwitterLinked InRedditEmail Cite Recommend Remember check out the Most...
Connected and autonomous vehicles (CAVs) have become the highlights of traffic. Researchers in this field proposed various traffic management measures to enhance capacity efficiency with CAVs, especially mixed CAVs manual (MVs). Exclusive lane setting is included. However, exclusive policy-related researches for MVs were very limited, influence number location lanes on was unclear. To fill gap, paper aims study different policies provide recommended under volumes CAV penetration rates....
Abstract The genus Delphinium (Ranunculaceae) with its unique and highly complex floral structure is an ideal system to address some key questions in terms of morphological evolutionary studies flowers. In D. anthriscifolium, for example, the original eight petal primordia differentiate into three types at maturity (i.e., two dorsal spurred, lateral flat, four ventral reduced petals). mechanisms underlying their identity determination differentiation remain unclear. Here, through a...
<h3>Background</h3> Mutations in the parkin gene (<i>PRKN</i>) cause autosomal recessive early-onset Parkinson disease (EOPD). <h3>Objective</h3> To investigate presence of mutations the<i>PRKN</i>gene a white family with EOPD and genotype-phenotype correlations. <h3>Design</h3> Twenty members belonging to 3 generations 4 affected subjects underwent genetic analysis. Direct genomic DNA sequencing, semiquantitative polymerase chain reaction, real-time quantitative reverse-transcriptase...
Nurr1 is a member of the nuclear receptor superfamily and potential susceptibility gene for Parkinson’s disease (PD). Several lines studies in vitro vivo reported that defects cause nigrostriatal neuronal deficiency as seen PD. In present study, we used synthetic low molecular weight activator which increases transcription to investigate whether it has anti-parkinsonian effects against degeneration induced by proteasome inhibitor lactacystin. Adult C57BL/6 mice were treated orally with an...
Ubiquitin proteasome system (UPS) impairment and iron misregulation have been implicated in dopamine (DA) neuron degeneration Parkinson's disease. As previously shown, inhibition a rodent model can cause nigral accompanied by accumulation. To investigate the involvement of DA degeneration, we generated an vitro applying inhibitor lactacystin DAergic cell line MES23.5 culture. We found that caused marked increase labile iron, reactive oxygen species ubiquitin-conjugated protein aggregation...
Background: Paired-like homodomain transcription factor 3 has been found to be important for the differentiation and survival of midbrain dopaminergic neurons. Methods: To determine whether genetic variation in coding region paired-like gene plays a role Parkinson's disease, analysis was performed 112 patients with disease. Results: We did not identify any mutations except rs2281983, but when we extended rs2281983 2 intron variants (rs4919621 rs3758549) 336 disease 244 controls, that...
<h3>Background</h3> Mutations in the parkin gene cause autosomal recessive early-onset Parkinson disease (EOPD). The<i>A265G</i>variant HS1 binding protein 3 (<i>HS1BP3</i>) is common essential tremor (ET). <h3>Objective</h3> To investigate presence of mutations and the<i>A265G</i>variant the<i>HS1BP3</i>gene a Mexican family with EOPD, ET, Bell palsy. <h3>Design</h3> Direct sequencing, semiquantitative polymerase chain reaction, reverse transcription–polymerase reaction were performed 14...
In vivo imaging plays an important role in investigating how the glymphatic system drains metabolic waste and pathological proteins from central nervous system. However, spatial resolutions specificities of available preclinical methods for are insufficient, they cannot simultaneously locate cerebrovascular pathways to enable monitoring perivascular cerebrospinal fluid dynamics. This Letter proposes strategy flow using co-localized photoacoustic volumetric microscopy. Imaging results showed...
As global climate change and human activities increasingly influence our world, forest fires have become more frequent, inflicting significant damage to ecosystems. This study conducted measurements of combustible materials (moisture content ratio, ignition point, calorific value) across 14 representative sites. We employed Pearson correlation analysis ascertain the differences in properties utilized entropy methods evaluate fire resistance at these Cluster led development four models. Using...