A5005526935- Mass Spectrometry Techniques and Applications
- Analytical Chemistry and Chromatography
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Chemical Synthesis and Analysis
- Fluorine in Organic Chemistry
- Advanced Chemical Physics Studies
- Zeolite Catalysis and Synthesis
- Synthesis and Biological Evaluation
- Organometallic Complex Synthesis and Catalysis
- Asymmetric Hydrogenation and Catalysis
- Chemical synthesis and alkaloids
- Alkaloids: synthesis and pharmacology
- Catalytic Processes in Materials Science
- Ion-surface interactions and analysis
- Carbon dioxide utilization in catalysis
- Catalysis and Oxidation Reactions
- Ferrocene Chemistry and Applications
- Metal complexes synthesis and properties
- Infective Endocarditis Diagnosis and Management
- Molecular Sensors and Ion Detection
- Cardiac, Anesthesia and Surgical Outcomes
- Click Chemistry and Applications
- Antibiotics Pharmacokinetics and Efficacy
- Cancer Treatment and Pharmacology
HUN-REN Research Centre for Natural Sciences
2015-2025
Institute of Organic Chemistry
2013-2025
Research Network (United States)
2024
Hungarian Research Network
2021-2023
Hungarian Academy of Sciences
2004-2018
Institute of Materials and Environmental Chemistry
2001
Eötvös Loránd University
2000
University of Debrecen
1976-1981
[Fe(Hdmg)2(MeIm)2] (1), referred to as ferroxime(II), is the precursor of a selective catalyst for oxidative dehydrogenation 2-aminophenol (Hap) 2-amino-3H-phenoxazine-3-one (apx) by dioxygen under ambient conditions. The superoxoferroxime(III) species has been detected ES-MS, and 4-substituted 2-aminophenoxyl free radical ESR technique. kinetics reaction was followed spectrophotometrically monitoring uptake at constant pressure. According proposed mechanism, solvolysis 1 O2 binding afford...
A fluorous analogue of Lawesson's reagent for thionation carbonyl compounds has been developed and its use demonstrated on a series amides, esters, ketones. The separation the reagent-derived byproducts can be achieved by simple solid-phase extraction.
Butyl phenyl-H-phosphinate that is not available commercially was prepared from phenyl-H-phosphinic acid by three methods: alkylating esterification (i), microwave-assisted direct (ii), and unexpectedly, thermal (iii). Considering the green aspects, selectivity scalability, variation seemed to be optimal. However, there need for prolonged heating. The butyl phenyl-H-phosphinate, along with ethyl analogue, utilized in synthesis of alkyl (α-alkylamino-arylmethyl-)phenyl phosphinates...
Energy-saving and cost-efficient reaction routes to prepare highly active catalysts for CO2 hydrogenation or solid oxide fuel cells (SOFCs) are enormously important. In this paper, we report a detailed study of dichromate salt [Fe(urea)6]3+, member the [M(urea)6]3+ complex family (M = Fe, Al, Mn, Cr, V, Ti) with oxidizing anions, which is promising precursor Cr-rich mixed chromium iron catalyst prepared at low temperature in phase. The single-crystal X-ray structure, various (infrared,...
An operationally simple and recoverable fluorous CBS methodology was developed. The in situ-generated oxazaborolidine efficiently catalyzed the reduction of ketones with high enantioselectivity reactivity. subsequent recycling prolinol precatalyst achieved by solid-phase extraction.
Protein labelling has a wide variety of applications in medicinal chemistry and chemical biology. In addition to covalent inhibition, specific biomolecules with fluorescent dyes is important both target discovery, validation diagnostics. Our research was conducted through the fragment-based development new benzyl-isothiocyanate-activated dye based on fluorescein scaffold. This molecule evaluated against isothiocyanate, prevalent agent. The reactivity selectivity phenyl- benzyl isothiocyanate...
2-Pyrazinyl and 3-pyridazinylketone arylhydrazones have been found to undergo ring-closure reaction under acid-catalyzed thermal conditions yield pyrazolo[3,4-b]pyrazines or pyrazolo[4,3-c]pyridazines. The proceeds in adequate good yields but its substrate scope was poorly studied. More emphasis placed on the cyclization mechanism which studied using quantum chemical calculations. calculations suggest a pericyclic pericyclicity is still favored acidic conditions. also basic for...
Abstract We have characterized site-specific N -glycosylation of the HeLa cell line glycoproteins, using a complex workflow based on high and low energy tandem mass spectrometry glycopeptides. The objective was to obtain highly reliable data common glycoforms, so rigorous evaluation performed. analysis revealed presence amount bovine serum contaminants originating from culture media – nearly 50% all glycans were origin. Unaccounted, components causes major bias in human cellular...
Heterogeneous copper catalysts were prepared by the deposition of CuI on a hybrid material consisting silica and polymer with imidazolium moieties. The solid materials characterised using solid‐phase NMR, Fourier transform infrared, Raman X‐ray photoelectron spectroscopies Brunauer–Emmett–Teller measurements. formation copper–carbene complexes was proved from spectra results supported density functional theory calculations. catalyst could be recycled efficiently low loss copper. Metal...
Abstract Redox behaviour of four imidazophenazine dye derivatives under mass spectrometric conditions matrix‐assisted laser desorption/ionization (MALDI), (LDI) from metal and graphite surface, electrospray, low temperature secondary ion spectrometry (LT SIMS) fast atom bombardment (FAB) was studied distinctions in the reduction‐dependent spectral patterns were analyzed point view different quantities protons electrons available for reduction techniques. The products [M + 2H] +• , 3H] M −•...
Qualitatively different membranotropic effects of the individual drugs and complexes formed in their combined use were demonstrated by differential scanning calorimetry.
Abstract Some approaches and examples are shown to demonstrate the usefulness of inherently ‘classical’ parameters, such as bond orders valences derivable from quantum mechanical wavefunctions, in description prediction mass spectral primary fragmentation processes.
Abstract Mechanisms of interaction between the antimicrobial drugs decamethoxinum and aethonium, which are based on bisquaternary ammonium compounds, a phospholipid component biological membranes, dipalmitoylphosphatidylcholine, were studied by means liquid secondary ion mass spectrometry (LSIMS) differential scanning calorimetry (DSC). Supramolecular complexes with this recorded under spectrometric conditions. The dependence structures these structural parameters dications compounds was...
Abstract In the course of a liquid secondary ion mass spectrometric (SIMS) investigation on bisquaternary ammonium antimicrobial agent, decamethoxinum, unusual pathways fragmentation organic dication M 2+ this salt, with preservation doubly charged state fragments, were observed. To reveal structural and electronic parameters which are responsible for stabilization its in gas phase, comprehensive SIMS study using metastable decay, collision‐induced dissociation kinetic energy release...
Rationale Protein citrullination (deimination) is a post‐translational modification of proteins converting arginine(s) into citrulline(s). “Overcitrullination” could be associated with severe pathological conditions. Mass spectrometric analysis modified hindered by several problems. A comprehensive study the fragmentation deiminated peptides not yet available. In this paper we have made an attempt to describe characteristics these processes, based on studies epitope model oligopeptides...
A study on some halofluorination and fluoroselenation protocols of various functionalized cyclic olefins, such as esters, lactams or amino esters model compounds is presented. The ring olefin bond functionalizations were based their activation either with NBS, NIS PhSeBr followed by treatment nucleophilic fluorinating agents, Deoxo-Fluor. attempted synthetic assays have been found to be highly substrate dependent, influenced the nature functional groups present cycloalkene skeleton well...