A5007097413- Spondyloarthritis Studies and Treatments
- Rheumatoid Arthritis Research and Therapies
- Psoriasis: Treatment and Pathogenesis
- Autoimmune and Inflammatory Disorders Research
- Bone and Joint Diseases
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Health Systems, Economic Evaluations, Quality of Life
- Systemic Lupus Erythematosus Research
- Spine and Intervertebral Disc Pathology
- Musculoskeletal pain and rehabilitation
- Systemic Sclerosis and Related Diseases
- Monoclonal and Polyclonal Antibodies Research
- Biosimilars and Bioanalytical Methods
- Scoliosis diagnosis and treatment
- COVID-19 and healthcare impacts
- Inflammasome and immune disorders
- Inflammatory Bowel Disease
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- COVID-19 Clinical Research Studies
- Pharmaceutical studies and practices
- Chronic Disease Management Strategies
- Cytokine Signaling Pathways and Interactions
- Autoimmune Bullous Skin Diseases
- Liver Disease Diagnosis and Treatment
- Healthcare Systems and Practices
Hospital Universitario Reina Sofía
2016-2025
University of Córdoba
2016-2025
Instituto Maimónides de Investigación Biomédica de Córdoba
2016-2025
Inserm
2018-2025
Sofia University
2023-2025
Sorbonne Université
2024-2025
Institut Pierre Louis d‘Épidémiologie et de Santé Publique
2024-2025
Hôpital Cochin
2018-2024
Sorbonne Paris Cité
2018-2024
Université Paris Cité
2018-2024
To update the Assessment of SpondyloArthritis international Society (ASAS)-EULAR recommendations for management axial spondyloarthritis (axSpA).Following EULAR Standardised Operating Procedures, two systematic literature reviews were conducted on non-pharmacological and pharmacological treatment axSpA. In a task force meeting, evidence was presented, discussed, overarching principles updated, followed by voting.Five 15 with focus personalised medicine agreed: eight remained unchanged from...
Objectives To characterise peripheral musculoskeletal involvement in patients with spondyloarthritis (SpA) including psoriatic arthritis (PsA), across the world. Methods Cross-sectional study 24 participating countries. Patients a diagnosis of axial SpA (axSpA), (pSpA) or PsA according to their rheumatologist were included. The investigators asked which out list six (axSpA, PsA, pSpA, inflammatory bowel disease-associated SpA, reactive juvenile (Juv-SpA)) fitted patient best. Peripheral...
To compare the benefits of a tight-control/treat-to-target strategy (TC/T2T) in axial spondyloarthritis (axSpA) with those usual care (UC).Pragmatic, prospective, cluster-randomised, controlled, open, 1-year trial (NCT03043846). 18 centres were randomised (1:1). Patients met Axial Spondylo Arthritis International Society (ASAS) criteria for axSpA, had an Ankylosing Spondylitis Disease Activity Score (ASDAS) ≥2.1, received non-optimal treatment by non-steroidal anti-inflammatory drugs and...
To develop a consensual definition for the term 'early axial spondyloarthritis-axSpA'-and peripheral spondyloarthritis-pSpA'.
Objective To assess whether the retention rate of certolizumab pegol (CZP) was longer than that other tumour necrosis factor inhibitors (TNFi) based on baseline rheumatoid (RF) levels. Methods Longitudinal, retrospective and multicentre study including patients with RA who were treated any TNFi (monoclonal antibodies (mAB), etanercept (ETA) or CZP). Log-rank test Cox regressions conducted to evaluate in three groups according level RF, third quartile levels used as cut-off: <200 (<Q3)...
To evaluate sacroiliac radiographic progression over a 10-year follow-up and determine the baseline factors associated with such in patients recent-onset axial spondyloarthritis (axSpA, <3 years).
Ankylosing spondylitis (AS) remains difficult to diagnose before irreversible damage sacroiliac joint is noticeable. Circulating microRNAs have demonstrated serve as diagnostic tools for several human diseases. Here, we analysed plasma identify potential AS biomarkers. Higher expression levels of microRNA (miR)-146a-5p, miR-125a-5p, miR-151a-3p and miR-22-3p, lower miR-150-5p, miR-451a were found in versus healthy donors. Interestingly, higher miR-146a-5p, miR-151a-3p, miR-22-3p was also...
Portable inertial measurement units (IMUs) are beginning to be used in human motion analysis. These devices can useful for the evaluation of spinal mobility individuals with axial spondyloarthritis (axSpA). The objectives this study were assess (a) concurrent criterion validity axSpA by comparing measured an IMU sensor-based system vs. optical capture as reference standard; (b) discriminant healthy volunteers; (c) construct results relevant outcome measures. A total 70 participants and 20...
Abstract Objectives To explore thresholds for the Psoriatic Arthritis (PsA) Impact of Disease questionnaire (PsAID12) score against disease activity measures in an observational setting, patients with PsA. Methods The baseline data from ReFlaP observational, prospective, multicentre and international study was used (NCT03119805). Cutoffs PsAID12 were determined scores, defining impact states (ie remission, low impact, moderate high impact). Statistics to assess optimal cutoff point included...
Objective To compare the clinical and sociodemographic characteristics of Ibero-American patients with radiographic axial spondyloarthritis (r-axSpA) to those European patients, a particular focus on influence HLA-B27. Methods This was an observational, cross-sectional, multicentre study who fulfilled Spondyloarthropathy Study Group (ESSG) criteria for SpA from REGISPONSER RESPONDIA registries. Univariate multivariate analyses between populations stratified by HLA-B27 status were conducted....
Background: Obesity is a frequent comorbidity in rheumatoid arthritis (RA). This condition may lead these patients to have poorer disease control and worse response some of the available treatments. Objectives: We aim analyze role body mass index (BMI) clinical Janus kinase inhibitors (JAKis) with RA. perform an in-depth analysis pathophysiology obesity by assessing serum adipokine levels, their potential influence activity changes treatment. Methods: study involved 81 RA treated JAKis from...
Objectives: To evaluate whether the diagnostic delay in patients with radiographic axial spondyloarthritis (r-axSpA) is associated poorer short-term outcomes after two years of follow-up. Methods: This was an observational, longitudinal, and prospective study including r-axSpA from national multicentre Spanish REGISPONSER-AS registry. Patients were divided into groups according to mean (<5 years, ≥5 years). Binary logistic regression models adjusted for disease duration constructed used...
To assess construct validity, including known-group discrimination, of the currently available disease activity instruments assessing peripheral arthritis in spondyloarthritis (SpA). In this analysis from Assessment SpondyloArthritis International Society (ASAS)-PerSpA study, patients with a diagnosis axial SpA, or psoriatic (PsA) were included. The evaluated Patient Global (PGA), Bath Ankylosing Spondylitis Disease Activity Index, Axial Spondyloarthritis Score, Index for PsA (DAPSA),...
Aims To explore the clinical and radiographical characteristics of axial psoriatic arthritis (PsA) to compare it with ankylosing spondylitis (AS) psoriasis. Methods Cross-sectional study from national multicentre registry REGISPONSER where participants fulfilled European Spondyloarthropathy Study Group spondyloarthritis criteria at entry. Clinical, laboratory between patients classified as PsA AS psoriasis by their rheumatologist are compared according HLA-B27 status. Results Of 2367 on...
Objectives 1) To characterize the inflammatory proteome of synovial fluid (SF) from patients with Psoriatic Arthritis (PsA) using a high-quality throughput proteomic platform, and 2) to evaluate its potential stratify according clinical features. Methods Inflammatory profile SF thirteen PsA active knee arthritis were analyzed proximity extension assay (PEA) technology (Olink Target 96 Inflammation panel). Four OA included as control group. Results Seventy-nine inflammation-related proteins...
Introduction RA patients are at higher risk of cardiovascular disease, influenced by therapies. Studying their and cardiometabolic proteome can unveil biomarkers insights into related biological pathways. Methods This study included two cohorts patients: newly diagnosed individuals (n=25) those with established (disease duration &gt;25 years, n=25). Both were age sex-matched a control group (n=25). Additionally, longitudinal investigation was conducted on cohort 25 treated methotrexate...