A5055355035- Rheumatoid Arthritis Research and Therapies
- Spondyloarthritis Studies and Treatments
- Systemic Sclerosis and Related Diseases
- Systemic Lupus Erythematosus Research
- Gout, Hyperuricemia, Uric Acid
- Dermatological and COVID-19 studies
- Chronic Lymphocytic Leukemia Research
- Salivary Gland Disorders and Functions
- Inflammatory Myopathies and Dermatomyositis
- COVID-19 Clinical Research Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Skin Diseases and Diabetes
- Long-Term Effects of COVID-19
- Venous Thromboembolism Diagnosis and Management
- Salivary Gland Tumors Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Autoimmune and Inflammatory Disorders Research
- Pneumonia and Respiratory Infections
- Liver Diseases and Immunity
- Psoriasis: Treatment and Pathogenesis
- Inflammation biomarkers and pathways
- Hip disorders and treatments
- IgG4-Related and Inflammatory Diseases
- Osteoarthritis Treatment and Mechanisms
- Diagnosis and Treatment of Venous Diseases
Children's Mercy Hospital
2024
Hospital de Sant Pau
2020-2024
Universitat Autònoma de Barcelona
2022-2024
Institut de Recerca Sant Pau
2024
Center for Rheumatology
2024
Hospital Universitari de Vic
2011
Objective To assess whether the retention rate of certolizumab pegol (CZP) was longer than that other tumour necrosis factor inhibitors (TNFi) based on baseline rheumatoid (RF) levels. Methods Longitudinal, retrospective and multicentre study including patients with RA who were treated any TNFi (monoclonal antibodies (mAB), etanercept (ETA) or CZP). Log-rank test Cox regressions conducted to evaluate in three groups according level RF, third quartile levels used as cut-off: <200 (<Q3)...
Abstract Objective To study subclinical inflammation in intercritical gout patients and its relation to the estimated size of monosodium urate crystal deposition cardiovascular risk factors. Methods We performed a secretome analysis quantification cytokine adipokine plasma levels [IL-1β, IL-18, IL-6, soluble IL-6 receptor (sIL-6R), TNF-α, C-X-C motif chemokine 5, RANTES (Regulated upon Activation, Normal T Cell Expressed Presumably Secreted), leptin, resistin adiponectin] analyse patients....
Refractory arterial hypertension (RAH) is frequently associated to a non-dipping blood pressure (BP) pattern; this profile has been shown have worse clinical prognosis. It common practice that patients receive anti-hypertensive medication preferentially in the morning. Non-dipping could be related timing of drug administration. We analysed whether switching bedtime improve BP control non-dipper with RAH. Twenty-seven consecutive RAH and or riser pattern on ambulatory (ABP) monitoring were...
: Cryoglobulinemia (CG) is marked by abnormal immunoglobulins (Ig) in serum, precipitating at temperatures below 37 °C. Current classification categorizes CG into three subtypes (types I, II, and III) based on Ig clonality. The features distinguishing patients with their etiology remain unidentified. Aiming to characterize clinical serological profiles of individuals, we conducted an observational analysis a large cohort compared characteristics underlying causes: hepatovirus (HV)...
Abstract Background Sarilumab, an IL-6 receptor antagonist, is a first-line biologic disease-modifying anti-rheumatic drug for rheumatoid arthritis. The identification of genetic biomarkers as predictors response to sarilumab could allow personalized treatment strategy improve clinical outcomes. Methods We conducted retrospective cohort study 62 patients treated with determine whether single-nucleotide polymorphisms (SNP) in the IL6R gene predict efficacy and toxicity responses. Six SNPs...
Rheumatoid arthritis (RA) is a prevalent autoimmune disease characterized by chronic that may lead to irreversible joint damage and significant disability. Patients with RA are commonly treated Tocilizumab (TCZ), an IL-6 receptor (IL-6R) antagonist, but many patients refractorily respond this therapy. Identifying genetic biomarkers as predictors of TCZ response could be key providing personalized medicine strategy. We aimed evaluate whether functional single nucleotide polymorphisms (SNPs)...
Introduction: We conducted a comprehensive comparative analysis of the Okazaki, Umehara, and American College Rheumatology/European League Against Rheumatism (ACR/EULAR) classification criteria for diagnosing immunoglobulin G4-related disease (IgG4-RD). Materials Methods: A retrospective study was in single tertiary hospital, using expert clinical judgment as gold standard. compared diagnostic accuracy ACR/EULAR cohort 41 patients with suspected IgG4-RD. assessed sensitivity, specificity,...
Background: Currently, there are no biomarkers to predict respiratory worsening in patients with Coronavirus infectious disease, 2019 (COVID- 19) pneumonia. Objectives: We aimed determine the prognostic value of Krebs von de Lungen-6 circulating serum levels (sKL-6) predicting COVID- 19 evolving trends. Methods: prospectively analyzed clinical and laboratory characteristics 375 mild lung disease on admission. sKL-6 was obtained all at baseline compared among worsening. Results: 45.1%...
Abstract Objective: To determine whether differences exist in antibiotic prescribing for respiratory infections pediatric urgent cares (PUCs) by patient race/ethnicity, insurance, and language. Design: Multi-center cohort study. Setting: Nine organizations (92 locations) from 22 states Washington, DC. Participants: Patients ages 6 months–18 years evaluated April 2022–April 2023, with acute viral infections, otitis media effusion (OME), (AOM), pharyngitis, community-acquired pneumonia (CAP),...
<h3>Background</h3> Idiopathic inflammatory myopathies (IIM) are a heterogeneous group of acquired muscle diseases, which have distinct clinical, pathological and histological features. Autoantibodies clinically useful biomarkers to help the diagnosis IIM. Raynaud's phenomenon is very frequent presence microvascular changes in IIM been described however, role nailfold videocapillaroscopy NVC) for prognosis not clearly established. <h3>Objectives</h3> The aim this study was relationship...
Introduction This was an ambispective cohort study evaluating the prognostic significance of lymphocytic foci and its lymphoid composition in minor salivary gland biopsy (MSGB) for short-term disease flare severity Sjögren’s syndrome (SS). Methods The inclusion criteria comprised individuals meeting ACR/EULAR 2016 who underwent MSGB with infiltration more than 50 lymphocytes received clinical diagnosis between September 2017 December 2018. Patients inadequate samples were excluded. number...
Abstract Background/Aims Idiopathic inflammatory myopathies (IIM) are a heterogeneous group of acquired muscle diseases with distinct clinical, pathological and histological features. Interstitial lung disease (ILD) is frequent pulmonary manifestation in IIM (IIM-ILD) considerably influences morbidity mortality. Krebs von den Lungen 6 (sKL-6) has been proposed as potential biomarker reflecting the severity ILD connective tissue diseases. Raynaud’s phenomenon very presence microvascular...
<h3>Background:</h3> Juvenile Idiopathic Arthritis (JIA) represents the most prevalent inflammatory rheumatic condition in childhood. Its heterogeneous nature presents challenges identifying feasible biomarkers for effective disease monitoring. Serum calprotectin (sCal) has emerged as a potentially valuable biomarker precisely assessing activity JIA. Despite various commercially available methods sCal determination, their usage remains limited and lacks validation. <h3>Objectives:</h3> To...
<h3>Background:</h3> Interstitial lung disease (ILD) stands as the primary cause of mortality in patients with Systemic Sclerosis (SSc). Despite identification several risk factors to develop ILD SSc, limited research has been directed towards understanding their impact on progression established SSc-ILD. <h3>Objectives:</h3> This study aims evaluate clinical characteristics SSc and compare features between those experiencing progressive function decline without such progression....
<h3>Background:</h3> Age, calcification and inflammatory burden may produce degenerative lesions in the aortic valve. It is described that root dilatation severe sclerosis of valve more frequently observed spondyloarthritis (SpA) patients compared to population without [1]. <h3>Objectives:</h3> Evaluate association between years disease evolution, age total time persistent inflammation as prognostic factors for Identify comorbidities associated with within context specified disease....
Abstract Introduction Integrated care pathways (ICPs) are crucial for delivering individualised care. However, the development of ICPs is challenging and must be well designed to provide expected benefits. Regarding this, healthcare organisations increasingly adopting management systems based on Lean Thinking improve their organisational processes by eliminating non‐value‐added steps. This study elucidates process evaluates impact applying redesign an ICP patients with spondyloarthritis, a...
Abstract Corresponding author: Amanda Nedved, MD, 6035 W 135th Street, Overland Park, KS 66223 785-243-6865 anedved@cmh.edu Funding Source: This work was supported by an investigator-initiated grant from Merck. Role of the Funder/Sponsor: The funder had no role in design and conduct study; collection, management, analysis, interpretation data; preparation, review, or approval manuscript; decision to submit manuscript for publication. Conflict Interest Disclosures: Dr. El Feghaly has research...
Tocilizumab is a first-line biologic disease-modifying anti-rheumatic drug (bDMARD) that inhibits the interleukin-6 (IL-6) pathway by antagonizing IL-6 receptor (IL-6R). widely used to treat rheumatoid arthritis (RA), prevalent autoimmune disease can cause irreversible joint damage and disability. Although many bDMARDs have been developed for RA, there lack of validated biomarkers which could guide personalized medicine strategies. To evaluate whether single-nucleotide polymorphisms (SNPs)...
Background: Patients with autoimmune inflammatory rheumatic diseases (AIIRD) have a higher burden of infectious compared to the general population. This could be explained by disturbances in their immune system response, comorbidities and immunosuppressive treatment.Vaccination is most effective measure prevent infections. Objectives: To describe cohort patients AIIRD referred disease´s unit according vaccination protocol. Methods: Restrospective descriptive study 286 who were evaluated...
<h3>Background</h3> The most important diagnostic test in Sjogren's syndrome is the minor salivary gland (MSGB). Immunohistochemical staining of MSGB may provide prognostic value for organ affection. <h3>Objectives</h3> To compare lymphocytic composition and major affection patients with during 3 years follow-up. worsening SSDDI index more than 2 points. <h3>Methods</h3> A retrospective cohort study was conducted. Inclusion criteria ≥18 that met 2016 ACR/EULAR Syndrome focal sialadenitis (≥1...
<h3>Background</h3> Little is known about the chronologic order of appearance extra-articular symptoms and spondylarthritis (SpA) its effect in disease progression. Most information based on population-based registries or big data that may lack precision. <h3>Objectives</h3> To describe duration, time until diagnosis articular (psoriasis, uveitis, inflammatory bowel disease) symptoms. evaluate factors associated with from onset SpA <h3>Methods</h3> A retrospective cohort study was conducted....