A5100637650- Acute Ischemic Stroke Management
- Venous Thromboembolism Diagnosis and Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracerebral and Subarachnoid Hemorrhage Research
- Anesthesia and Neurotoxicity Research
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Neuroinflammation and Neurodegeneration Mechanisms
- Cardiac Ischemia and Reperfusion
- Inflammatory Biomarkers in Disease Prognosis
- Circular RNAs in diseases
- Immune cells in cancer
- Ferroptosis and cancer prognosis
- Face recognition and analysis
- Phagocytosis and Immune Regulation
- Bacterial Infections and Vaccines
- RNA modifications and cancer
- RNA Research and Splicing
- MRI in cancer diagnosis
- S100 Proteins and Annexins
- Apelin-related biomedical research
- Neurosurgical Procedures and Complications
- Neurological Disease Mechanisms and Treatments
- Bone and Joint Diseases
- Neurobiology of Language and Bilingualism
First Hospital of Jilin University
2016-2025
Jilin University
2016-2025
Anhui Provincial Children's Hospital
2015-2025
Beijing Tongren Hospital
2024
Capital Medical University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2018-2024
Liaoning University of Traditional Chinese Medicine
2024
Guangxi Normal University
2023
South China University of Technology
2023
The Affiliated Hospital to Changchun University of Chinese Medicine
2023
The protective effects of remote ischemic conditioning (RIC) on acute stroke have been reported. However, the mechanisms RIC not fully elucidated. This study aimed to investigate whether could reduce oxidative stress and inflammatory responses in middle cerebral artery occlusion (MCAO)-reperfusion mice via nuclear factor-E2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) pathway. C57BL/6 were subjected MCAO underwent twice daily at 1, 3, 7 days after MCAO. ML385 was used specifically inhibit...
To investigate the characteristics of dynamic cerebral autoregulation (dCA) in patients after mechanical thrombectomy (MT) and relationship between dCA prognosis. In this prospective study, 89 158 were enrolled MT non-MT groups, respectively. Both groups underwent measurements within 3 days stroke. The transfer function parameter, phase difference (PD), gain used to quantify dCA. A favorable outcome was defined as a modified Rankin Scale score ≤ 2 at 90 days. collateral reflect reserve...
18F-fluorodeoxyglucose (18F-FDG) positron emission tomography has become an important tool for detection, staging and management of many types cancer. Oncology application 18F-FDG bases on the knowledge that increase in glucose demand utilization is a fundamental features Pasteur effect, Warburg effect reverse have been used to explain metabolism accumulation cancer reportedly microenvironment-dependent, avidly accumulates poorly proliferating hypoxic cells, but low well perfused (and...
Background The changes in the platelet-to-lymphocyte ratio (PLR) before and after recombinant tissue plasminogen activator (rtPA) treatment time point at which PLR is a potentially valuable prognostic predictor patients wit ischemic stroke remain largely unknown. Therefore, purpose of this study was to explore characteristics evaluate their effects on clinical outcomes 24 h rtPA treatment. Methods This included 741 consecutive with acute who underwent intravenous thrombolysis rtPA. We...
Streptococcus pneumoniae (S. pneumoniae) is a major causative agent of respiratory disease in patients and can cause distress other symptoms severe cases. Pneumolysin (PLY) pore-forming toxin that induces host tissue injury inflammatory responses. Sortase A (SrtA), catalytic enzyme anchors surface-associated virulence factors, critical for S. virulence. Here, we found the active ingredient Chinese herb Scutellaria baicalensis, wogonin, simultaneously inhibited haemolytic activity PLY SrtA...
Current therapeutic strategies for ischemic stroke fall short of the desired objective neurological functional recovery. Therefore, there is an urgent need to develop new methods treatment this condition. Exosomes are natural cell-derived vesicles that mediate signal transduction between cells under physiological and pathological conditions. They have low immunogenicity, good stability, high delivery efficiency, ability cross blood-brain barrier. These properties exosomes potential lead...
Hypertensive intracerebral hemorrhage (ICH) is a devastating cerebrovascular disease with no effective treatment. Lysyl hydroxylase 3 (LH3) essential for collagen IV intermolecular crosslinking and stabilization. Deficiency in LH3 affects the assembly secretion of basement membrane (BM) integrity vessels. Here, we investigated whether has significant implications progression therapeutic intervention. Spontaneous hypertensive ICH mice was induced by angiotensin II L-NAME The adeno-associated...
Recent studies have demonstrated the positive roles of remote ischemic conditioning (RIC) in patients with cerebrovascular diseases; however, mechanisms remain unclear. This study aimed to explore effect serial RIC on dynamic cerebral autoregulation (dCA) and serum biomarkers associated brain injury, both which are related prognosis disease.This was a self-controlled interventional healthy adults. The conducted twice day for 7 consecutive days (d1-d7) comprised 4 × 5-min single arm cuff...
Osteogenesis is the differentiation of mesenchymal stem cells (MSCs) into osteoblasts. MicroRNAs (miRNAs) are short noncoding RNAs that target specific genes to mediate translational activities. In this study, we investigated how miR-224 regulates osteoblastic human MSCs (hMSCs) as well underlying mechanism. The results revealed upregulation during hMSC differentiation. vitro experiments showed downregulation suppressed hMSCs However, was concomitant with increased expression relevant and...
Background and Purpose: Platelet-to-neutrophil ratio (PNR) was suggested to be an independent protective predictor for 90-days outcomes in acute ischemic stroke (AIS) patients previous studies. This study aims investigate the association between PNR of AIS intravenous thrombolysis (IVT) group. Methods: Data on who received from April 2015 March 2019 were collected. We defined value at admission as pre-IVT after IVT within 24 h post-IVT PNR. Clinical outcome indicators included early...
This article has been retracted, and the online PDF replaced with this retraction notice.
Intracerebral hemorrhage (ICH) is a severe stroke subtype with high morbidity, disability, and mortality rates. Currently, no biomarkers for ICH are available use in clinical practice. We aimed to explore the roles of RNAs pathogenesis identify potential diagnostic biomarkers.
In previous studies, alkaline phosphatase (ALP) level was a prognostic factor for patients with ischemic stroke, and globulin associated hemorrhagic transformation (HT) after intravenous thrombolysis (IVT). However, the association between these serum biomarkers prognosis in acute stroke (AIS) who undergo IVT remains unclear. This study aimed to investigate characteristics of ALP levels assess relationship prognosis.This retrospective used prospectively collected database. We included AIS...
<title>Abstract</title> Background This study aimed to evaluate the effects of caudal block anesthesia with hydromorphone-ropivacaine compared ropivacaine alone on postoperative immune function and pain management in children undergoing hypospadias surgery. Methods A total 100 pediatric patients were randomly assigned two groups: Hydromorphone-Ropivacaine (HR) group Ropivacaine (R) group, 50 each group. Demographic clinical characteristics compared. T lymphocyte subsets (CD3+, CD4+, CD8+,...
Objective To assess the impact of lateral position changes on intraocular pressure and regional cerebral oxygen saturation (rScO 2 ) in patients undergoing surgery. Methods Seventy were categorized into elderly middle-aged groups, with 35 individuals each. Apart from collecting physiological data patients, was measured using a rebound tonometer, levels assessed monitor at ten different time points this study. Results Intraocular trends both eyes similar peaking after two hours then...