A5101869884- Soft Robotics and Applications
- Advanced Sensor and Energy Harvesting Materials
- Electric Power System Optimization
- Cancer Genomics and Diagnostics
- Cancer-related molecular mechanisms research
- Cancer Cells and Metastasis
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Electrical and Bioimpedance Tomography
- Microstructure and Mechanical Properties of Steels
- Circular RNAs in diseases
- Magnetic Properties and Applications
- Advanced Algorithms and Applications
- Stock Market Forecasting Methods
- Micro and Nano Robotics
- Water resources management and optimization
- Flow Measurement and Analysis
- Energy Load and Power Forecasting
- Peptidase Inhibition and Analysis
- High-Velocity Impact and Material Behavior
- Metallurgy and Material Forming
- Body Composition Measurement Techniques
- Extracellular vesicles in disease
- Protein Degradation and Inhibitors
Nanjing Medical University
2011-2025
Jiangsu Province Hospital
2019-2025
Henan Polytechnic University
2023-2024
Jinan University
2024
University of Science and Technology of China
2024
Jiangsu University
2022
Second Affiliated Hospital of Nanjing Medical University
2022
Shengli Oilfield Central Hospital
2011
Baotou Teachers College
2009
China Three Gorges Corporation (China)
2005-2007
Abstract Molecular mechanisms underlying breast cancer lymph node metastasis remain unclear. Using single-cell sequencing, we investigated the transcriptome profile of 96,796 single cells from 15 paired samples primary tumors and axillary nodes. We identified nine cell subclusters including CD44 + / ALDH2 /ALDH6A1 stem (BCSCs), which had a copy-number variants similar to that normal tissue. Importantly, BCSCs existed only in evolved into metastatic clusters infiltrating Furthermore, data...
Triple-negative breast cancer (TNBC) is highly aggressive with a poor clinical prognosis and no targeted therapy. The c-Myc protein master transcription factor potential therapeutic target for TNBC. In this study, we develop PROTAC (PROteolysis TArgeting Chimera) based on TNA (threose nucleic acid) DNA that effectively targets degrades c-Myc. aptamer selected in vitro to bind the c-Myc/Max heterodimer appended E-box sequence create high-affinity, biologically stable bivalent binder. TNA-E...
Image reconstruction of Electrical Impedance Tomography (EIT) is a highly nonlinear ill-posed inverse problem, which sensitive to the measurement noise and model errors. An improved Convolutional Neural Network (CNN) method proposed for EIT lung imaging. The optimized based on Visual Geometry Group (VGG) model, adding batch normalization (BN) layer, ELU activation function, global average pooling (GAP) radial basis function (RBF) neural network. These optimizations help speed up network...
As a transcription factor and proto-oncogene, MYC is known to be deregulated in variety of tumors, including breast cancer. However, no consistent conclusion on the role mechanism deregulation during cancer carcinogenesis has been formed. Here, we used UALCAN, bc-GenExMiner, TCGA, cBioportal, STRING Kaplan-Meier Plotter databases explore mRNA expression, prognosis, transcriptional profile changes, signal pathway rewiring interaction with stem cells We found that expression varies different...
It is imperative to explore biomarkers that are both precise and readily accessible in the comprehensive management of breast cancer. A multicenter cohort, including 512 cancer patients 198 nonneoplastic individuals, was recruited detect level tumor-derived extracellular vesicles using our method based on dual DNA tetrahedral nanostructures. The significantly higher newly diagnosed than individuals at a cutoff value 3.58 U/μL. For postoperative metastasis monitoring, with those without 3.91...
Extracellular vesicles (EVs) play a crucial role as important mediators of intercellular communication in the progression tumors. The capture and analysis tumor-derived EVs offer new possibilities for application cancer liquid biopsies. This study aims to construct DNA tetrahedral nanostructure that specifically recognizes HER2 CD63, enabling effective enrichment detection HER2-expressing (HEVs). We enriched HEVs from cell lines 13 random clinical samples validated their characteristics by...
Circulating tumor cell clusters/micro-emboli (CTM) possess greater metastatic capacity and survival advantage compared to individual circulating (CTC). However, the formation of CTM subtypes their role in metastasis remain unclear. In this study, we used a microfluidic Cluster-Chip with easy operation high efficiency isolate from peripheral blood, which confirmed correlation clinicopathological features identified critical CTC-platelet clusters breast cancer metastasis. The between platelets...
The difference in transformation mechanisms between the normal and reverse phase medium Mn steel was revealed using thermodynamic kinetic analysis. results indicate that austenite formation during is a fast reaction, significant amount of 46.9 vol% retained obtained after subjected partial reversion at 650 °C × 1 h. At nucleation stage, lath-like structure, dislocations, martensitic packet boundaries, grain boundaries provide high-density sites for formation. critical temperature reduced by...
To examine plasma microRNA-21 (miR-21) level in patients with non-small cell lung cancer (NSCLC) and its potential correlation chemotherapeutic response.77 NSCLC 36 age sex-matched healthy controls were included. Plasma miR-21 concentration was examined using a quantitative real-time reverse transcription polymerase chain reaction assay (qRT-PCR). Potential between mir-21 concentrations responses analyzed 35 advanced (stages IIIB IV).Plasma significantly higher relative to the (P<0.0001). As...
Cancer immunotherapy has emerged as a promising strategy against triple-negative breast cancer (TNBC). One of the immunosuppressive pathways involves programmed cell death-1 (PD-1) and death ligand-1 (PD-L1), but many patients derived little benefit from PD-1/PD-L1 checkpoint blockades treatment. Prior research shown that MYC, master transcription amplifier highly expressed in TNBC cells, can regulate tumor immune microenvironment constrain efficacy immunotherapy. This study aims to...
Visualization of breast tumors with 3-D bioelectrical impedance spectroscopic tomography (3D-BIST) is proposed to identify the position, size, benignity, and malignancy tumors. First, visualize in 3-D, a conical sensor developed based on actual shape breast. Second, confirm feasibility method, finite element simulation employed. The influence different spectroscopy data acquisition methods (0-, 1-, 3-skip) classifiers [Linear-SVM, radial basis function-support vector machines (RBF-SVM),...
Studies have shown cell鄄 free microRNA (miRNA) circulating in the serum and plasma with specific expression cancer, indicating potential of using miRNAs as biomarkers for cancer diagnosis therapy.This study was to investigate whether miRNA鄄 21 (miR鄄 21) can be used a biomarker early detection non-small cell lung (NSCLC) explore its association clinicopathologic features sensitivity platinum鄄 based chemotherapy.We real鄄 time RT鄄 PCR miR鄄 63 NSCLC patients 30 healthy controls correlated...
Cyclin-dependent kinase 7 (CDK7) belongs to CDK family, which is involved in transcriptional activity and cell cycle progression. Recent studies have suggested that CDK7 inhibitor effective the treatment of breast cancer, whereas, efficacy antitumor response varies significantly different subtypes cancer. However, underlying connection between molecular cancer currently unknown.To further elucidate role we investigated association expression with clinical outcomes using Oncomine, GENT2,...
A hybrid Genetic Expression Program and Algorithm (GEP-GA) is proposed for auto-modeling the Electrical Equivalent Circuit (EEC) of particle structure measurement with Electrochemical Impedance Spectroscopy (EIS). It combines GEP ability searching mathematical models GA electrical parameters global searching. The used to modeling EEC EIS, calculate fitness EEC. method has advantage no need manually set. Firstly, reconstruct simulation model simultaneously its parameters. results show that...
Aims: This study investigates the association between circulating tumor cells (CTCs) and breast cancer metastasis. Methods: A retrospective was conducted using patients with histologically confirmed recruited from First Affiliated Hospital of Nanjing Medical University during period August 2017−October 2020. We used adjusted logistic regression, random forest algorithm, sensitivity analysis to CTC enumeration Further, we performed next-generation sequencing (NGS) on CTCs obtained two brain...