A5101807739- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Lung Cancer Research Studies
- interferon and immune responses
- MicroRNA in disease regulation
- RNA modifications and cancer
- Reproductive Health and Technologies
- Gastrointestinal motility and disorders
- RNA Research and Splicing
- Innovative Microfluidic and Catalytic Techniques Innovation
- Sepsis Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Molecular Biology Techniques and Applications
- Ubiquitin and proteasome pathways
- Genetic factors in colorectal cancer
- Process Optimization and Integration
- Immune Cell Function and Interaction
- Cancer Mechanisms and Therapy
- Assisted Reproductive Technology and Twin Pregnancy
- Diet and metabolism studies
- HER2/EGFR in Cancer Research
- Colorectal Cancer Treatments and Studies
- Radiomics and Machine Learning in Medical Imaging
- Circular RNAs in diseases
Jiaxing University
2019-2024
Guangzhou Medical University
2022
Guangzhou Women and Children Medical Center
2022
First Hospital of Jiaxing
2019-2021
Xiamen University
2014-2016
Abstract As a Gram‐negative anaerobic bacterium, Akkermansia muciniphila (AKK) participates in the immune response many cancers. Our study focused on factors and molecular mechanisms of AKK affecting escape lung adenocarcinoma (LUAD). We cultured bacteria, prepared outer membrane protein Amuc_1100 constructed subcutaneous graft tumour mouse model. A549, NCI‐H1395 cells mice were respectively treated with inactivated AKK, Amuc_1100, Ruxolitinib (JAK inhibitor) RO8191 activator). CD8 + T that...
Background This study investigated the inhibitory effects of lncRNA HLA Complex Group 11 (HCG11) on non-small cell lung cancer (NSCLC) and molecular mechanisms.
Abstract The human small intestine is responsible for virtually all nutrient uptake and more than 95% of the water absorption in digestion, which attributed to vast mucosal surface area peristalsis intestine. Under broad conceptual framework bio-inspired chemical process engineering, by mimicking structure functions intestine, a flexible tubular reactor with villous protrusions distributed evenly on inner wall was designed constructed this study. In order understand flow behavior reactor,...
The outbreak of coronavirus disease 2019 (COVID-19) has globally strained medical resources and caused significant mortality. This study was aimed to develop validate a prediction model based on clinical features estimate the risk patients with COVID-19 at admission progressing critical patients. Patients admitted hospital between January 16, 2020, March 10, were retrospectively enrolled, they observed for least 14 days after determine whether developed into severe pneumonia. According...
Objective: This study investigates the relationship between HOXA11-AS/let-7c-5p/IGF2BP1 regulatory axis and lung adenocarcinoma. Methods: The expression levels of HOXA11-AS, let-7c-5p, IGF2BP1 were evaluated in LUAD tissue cell lines. Subcellular fractionation detection assay was adopted to verify HOXA11-AS distribution cells. interaction let-7c-5p or validated by dual-luciferase reporter detection. In RNA binding protein immunoprecipitation assay, identified. viability transfected cells...
Colorectal cancer (CRC) is among the most common cancers diagnosed worldwide. Although genome-wide association studies have effectively identified genetic basis of CRC, there still unexplained variability in risk. Transcriptome-wide (TWAS) integrate summary statistics from CRC (GWAS) with gene expression data to prioritize these GWAS findings and uncover additional gene-trait correlations.First, we carried out a post-GWAS analysis using large-scale (n = 4,562 cases, n 382,756 controls)....
Abstract Objective This study aimed to construct a nomogram effectively predict the overall survival (OS) of patients with early-stage non-small-cell lung cancer (NSCLC). Methods For training and internal validation cohorts, total 26,941 stage I II NSCLC were obtained from Surveillance, Epidemiology, End Results (SEER) database. A was constructed based on risk factors affecting prognosis using Cox proportional hazards regression model. And 505 recruited Jiaxing First Hospital for external...
Lung cancer has a higher incidence and mortality rate than other cancers, over 80% of lung cases were classified as non-small-cell (NSCLC). TRIM66 is one the crucial members TRIM, which deep connection with behavior various malignant tumors. But it remains uncertain regarding its exact function underlying mechanism in NSCLC. In our study, qRT-PCR Western blot employed to validate that was overexpressed The migration, invasion, epithelial-mesenchymal transformation (EMT) progression NSCLC...
Abstract Background: Sperm quality can be easily influenced by environment and occupations factors. Yet, due to complexity diversity of factors we are facing in everyday life, there difficulties collecting patients’ information the outpatient department, which might influence sperm then lengthen TTP remain largely unexplored. This study aimed discover potential semen related as well occupation factors, assist clinical decision making. Methods: A total 465 men were recruited from...