The purpose of this study was to investigate the effect intestinal dysbiosis on bioavailability voriconazole and explore any underlying mechanisms. Sprague-Dawley rats were randomly divided into two groups: a normal control group ceftriaxone-associated dysbiotic group. composition flora examined using 16S rRNA sequencing analysis. Voriconazole concentrations determined by high-performance liquid chromatography-tandem mass spectrometry. Outer membrane vesicles (OMVs) microbes from different...

Voriconazole (VRC), a widely used antifungal drug, often causes hepatotoxicity, which presents significant clinical challenge. Previous studies demonstrated that

Wireless capsule endoscopy (WCE) plays an important role in the diagnosis of gastrointestinal diseases. However, it is very time-consuming and fatiguing for a physician to review large number WCE images. Some methods address this problem have recently been presented. these generally employ classification algorithms discriminate abnormal from normal images, which do not localize, recognize, or detect patterns We sought identify better method pattern detection. In paper, convolutional neural...

Here, we report a novel polymeric nanoparticle prepared by the self-assembly of amphiphilic copolymers containing fluorescent naphthalimide (NAPH) and photochromic spiropyran (SP), which possesses reversibly photoswitchable dual-color fluorescence controlled release properties. The were synthesized incorporating NAPH SP into methyl ether poly(ethylene glycol)-poly(β-amino esters) (MPEG-PAE) via quaternization. nanoparticles would change between yellow purple upon UV visible light irradiation...

An advanced metering infrastructure (AMI) system plays a key role in the smart grid (SG), but it is vulnerable to cyberattacks. Current detection methods for AMI cyberattacks mainly focus on data center or distributed independent node. On one hand, difficult train an excellent intrusion model self-learning other large amounts of are shared over network and uploaded central node training. These processes may compromise privacy, cause communication delay, incur high costs. With these...

Purpose: This study aims to investigate the effects of Huang Gan formula (HGF), a Chinese herbal prescription used for chronic kidney disease (CKD), on regulation gut microbiota and colonic microenvironment CKD. Methods: CKD rats were induced by 150 mg/kg adenine gavage 4 weeks, then orally treated with or without 3.6 g/kg 7.2 HGF 8 weeks. The renal function structure analyzed biochemical detection, hematoxylin eosin, Masson’s trichrome, Sirius red immunochemical staining. Average fecal...

The antifungal agent voriconazole (VRC) exhibits extreme inter-individual and intra-individual variation in terms of its clinical efficacy toxicity. Inflammation, as reflected by C-reactive protein (CRP) concentrations, significantly affects the metabolic ratio trough concentrations voriconazole. Bacteroides fragilis ( B. ) is an important component human intestinal microbiota. Clinical data have shown that abundance comparatively higher patients not presenting with adverse drug reactions,...

This study explores the potential role of a highly selective caspase-1 inhibitor, VX-765, on extracellular matrix (ECM) accumulation and inflammation in diabetic nephropathy (DN) underlying mechanisms.DN rats, induced via high-fat diet/streptozotocin, were used to assess effects VX-765. Parallel experiments carried out rat mesangial cell line HBZY-1 exposed high glucose (HG) reveal molecular mechanism VX-765 preventing DN. Survival analysis, biochemical parameters renal oxidative stress rats...

In existing delegation models, security entirely depends on delegators and administrators, for constraint in these models is only a prerequisite condition. This paper proposes an Attribute-Based Delegation Model (ABDM) with extended consisting of both attribute expression (DAE) condition (CR). ABDM, delegatee must satisfy (especially DAE) when assigned to role. With constraint, delegator can restrict the candidates more strictly. ABDM relieves administrators management work delegation. not...

Requirements verification for complex software system has become more and important in requirements engineering it is one of the most helpful strategies improving quality system. Related work shows that requirement elicitation analysis can be facilitated by semantic technologies domain ontology. A new methodology verifying with structural formal semantics based on ontology proposed this paper. Requirement specification processed natural language decomposed into a set atomic items which are...

Due to the fact that it is more and improbable a system administrator recognize manually intervene stop an attack, there increasing recognition ID systems should have lot earn on following its basic principles behavior of complex natural systems, namely in what refers self-organization, allowing for real distributed collective perception this phenomena. A clustering model based self-organizing ant colony networks (CSOACN) systematically proposed intrusion detection system. Instead using...

Cloud computing have brought a lot of advantages, such as reducing the hardware cost and providing convenient cloud storage service. More more people choose to put their private data in cloud. To improve security privacy, Wu et al. proposed new extensive access control scheme for multi-authority systems (NEDAC-MACS) on basis Yang In this paper, we propose that can resist collusion server user NEDAC-MACS. The cryptographic analysis show our is still secure random oracle.

Aiming at the cyber security problem of advanced metering infrastructure(AMI), an anomaly detection method based on edge computing framework for AMI is proposed. Due to characteristics node data concentrator, concentrator has capability a large amount data. In this paper, distributing intrusion model instead center, meanwhile, two-way communication distributed local parameters replaces transmission. The proposed avoids risk privacy leakage during in AMI, and it greatly reduces delay...

Delegation constraint of current delegation models is mostly prerequisite conditions. In these models, security fully depends on delegator and administrator. many cases, we need a more secured with strict constraint. This paper proposes an Attribute-Based-Delegation-Model (ABDM) extended The in ABDM includes attribute expression (DAE) ABDM, delegatee must satisfy (especially DAE) when assigned to role. With this constraint, can restrict the candidate strictly. relieves management effort...

In mobile IPv6, the location of a node (MN) is obtained by implementing binding update (BU) process. During process, unauthenticated BU message may give rise to many security risks, such as denial-of-service (DoS) attack. Thus, authentication most important for IPv6. The purpose cryptographically generated addresses (CGA) prevent stealing and spoofing existent IP addresses. this paper, novel mechanism based on CGA proposed in With implementation mechanism, care-of address MN will be...