A5101584493- Assisted Reproductive Technology and Twin Pregnancy
- TGF-β signaling in diseases
- Diet and metabolism studies
- Ovarian function and disorders
- Circular RNAs in diseases
- Bladder and Urothelial Cancer Treatments
- Advanced Breast Cancer Therapies
- Pluripotent Stem Cells Research
- MicroRNA in disease regulation
- Sperm and Testicular Function
- Renal and related cancers
- Vitamin D Research Studies
- Cancer-related Molecular Pathways
- Epigenetics and DNA Methylation
- Reproductive Health and Technologies
- Thyroid Cancer Diagnosis and Treatment
- Signaling Pathways in Disease
- Molecular Communication and Nanonetworks
- Hypothalamic control of reproductive hormones
- Hedgehog Signaling Pathway Studies
- Surgical site infection prevention
- Phytochemistry and Biological Activities
- Cancer Mechanisms and Therapy
- Shoulder Injury and Treatment
- FOXO transcription factor regulation
Universidad del Noreste
2025
Southern Medical University Shenzhen Hospital
2022-2024
Xuzhou Medical College
2023
Chinese University of Hong Kong, Shenzhen
2023
Columbia University
2023
Shanghai Jiao Tong University
2023
Xi'an Polytechnic University
2023
Third Affiliated Hospital of Guangzhou Medical University
2021-2022
Guangzhou Medical University
2021-2022
Zhengzhou University
2021-2022
Abstract Cyclin-dependent kinases 4 and 6 (CDK4/6) are critical for initiating cell proliferation by inactivating the retinoblastoma (Rb) protein. However, mammalian cells can bypass CDK4/6 Rb inactivation. Here we show a non-canonical pathway inactivation its interplay with external signals. We find that non-phosphorylated protein in quiescent is intrinsically unstable, offering an alternative mechanism E2F activity. Nevertheless, this incompletely induces Rb-protein loss, resulting minimal...
Cyclin-dependent kinase 4 and 6 inhibitors (CDK4/6i) are key therapeutic agents in the management of metastatic hormone-receptor-positive breast cancer. However, emergence drug resistance limits their long-term efficacy. Here, we show that cancer cells develop CDK4/6i via a sequential two-step process E2F activation. This entails retinoblastoma (Rb)-protein degradation, followed by c-Myc-mediated amplification transcriptional activity. treatment halts cell proliferation an Rb-dependent...
Thirty compounds including 13 new phenolic glycosides (1-6, 9-15) and 17 known aromatic (7-8, 16-30) were isolated from the roots of Wrightia pubescens. The structures established by extensive NMR spectroscopic data analysis as well chemical derivatization method. evaluated for their hepatoprotective activities using cell model acetaminophen (APAP)-induced HepG2 cells. results indicated that (2, 4, 5, 7, 8, 11, 13) pretreatment enhanced cells viability reduced levels aspartate...
Purpose: This study aims to investigate the effects of Huang Gan formula (HGF), a Chinese herbal prescription used for chronic kidney disease (CKD), on regulation gut microbiota and colonic microenvironment CKD. Methods: CKD rats were induced by 150 mg/kg adenine gavage 4 weeks, then orally treated with or without 3.6 g/kg 7.2 HGF 8 weeks. The renal function structure analyzed biochemical detection, hematoxylin eosin, Masson’s trichrome, Sirius red immunochemical staining. Average fecal...
The sperm chromatin structure assay (SCSA) is crucial for assessing male fertility. However, the predictive value of SCSA parameters, including DNA fragment indices (DFI) and percentages high stainability (HDS), outcomes artificial insemination by husband (AIH) remains controversial. This study aims to evaluate correlations between parameters aging as well other routine semen explore their prognostic powers on AIH Chinese infertile couples. A total 809 cycles were retrospectively analyzed....
Metastatic thyroid cancers are more difficult to treat and have a significantly worse prognosis than localized cancers. Previous studies shown that follicular helper T cells (Tfh) may participate in antitumor immune responses. Here, we investigated the characteristics of Tfh patients with differentiated cancer (DTC) at various severities, including disease, cervical metastasis, distant metastasis. In circulating CD4 cells, proportion + CXCR5 Tfh‐like was higher metastasis healthy controls,...
A novel bacterial strain, designated as PHS-Z21 T , was isolated from the marine sponge Cinachyrella kuekenthali collected PG Dave’s Rock, Philippines. Cells of are Gram-stain-negative, non-motile, pale-yellow-pigmented, short rods. is able to grow at 10–40 ℃ (optimum, 30 ℃), pH 5.5–9.0 8.5) and with 3–9 % (w/v) NaCl 4 %). Its 16S rRNA gene sequence shows 98.6 similarity Qipengyuania nanhaisediminis CGMCC 1.7715 98.5 vulgaris 022-2-10 98.4 flava SW-46 respectively. The phylogenetic tree...
Background: To determine the independent prognostic factors and develop a multivariate logistic regression model for predicting successful pregnancy following artificial insemination by husband (AIH) in infertile Chinese couples. Methods: A total of 3,015 AIH cycles with superovulation from 1,853 couples were retrospectively analyzed. The clinical characteristics sperm parameters compared between pregnant non-pregnant groups. Multivariate analysis was performed to remove confounding create...
To determine the predictive values of sperm parameters pre- and post-processing by density gradient centrifugation for clinical pregnancy rates (CPRs) following artificial insemination husband (AIH) in infertile Chinese couples.A total 3,522 AIH cycles from 1,918 couples were retrospectively analyzed. The compared between pregnant non-pregnant groups further different etiological (Male-factor, Both-male-and-female-factor, Other-factor). Multivariate logistic regression analysis was performed...
Thyroid is a one of the most important endocrine organs. Understanding molecular mechanism underlying thyroid development and function, as well diseases, beneficial for clinical treatment diseases tumors. Through genetic linkage analysis exome sequencing, we previously identified an uncharacterized gene C14orf93 (RTFC, mouse homolog: 4931414P19Rik) novel susceptibility familial non-medullary carcinoma, demonstrated its function in promoting tumor. However, role RTFC remains unexplored. In...
: Studies suggest that vitamin D is involved in the development of type 2 diabetes mellitus (T2DM) and influences serum lipids levels, while lipid disorders are also closely related to T2DM. This study attempts explore complex relationship 25(OH)D
The testicular disorder of sex development (TDSD) is a rare condition characterized by male appearance with female karyotype. most frequent cause TDSD misplacement the determining region Y (SRY) gene on X chromosome. Here, we report generation an induced pluripotent stem cell (iPSC) line from peripheral blood mononuclear cells patient SRY-positive 46,XX TDSD. This offers unprecedented cellular model to investigate profound manifestations like infertility reversal patients, and serves as...