A5066412691- Photoreceptor and optogenetics research
- Lipid Membrane Structure and Behavior
- Cellular Mechanics and Interactions
- Neuroscience and Neuropharmacology Research
- DNA and Nucleic Acid Chemistry
- Force Microscopy Techniques and Applications
- Advanced biosensing and bioanalysis techniques
- Advanced Fluorescence Microscopy Techniques
- Cardiomyopathy and Myosin Studies
- Muscle Physiology and Disorders
- Microfluidic and Bio-sensing Technologies
- Ethnobotanical and Medicinal Plants Studies
- Neurological disorders and treatments
- Cellular transport and secretion
- Advanced Electron Microscopy Techniques and Applications
- Mitochondrial Function and Pathology
- Synthesis and Characterization of Heterocyclic Compounds
- Phytochemistry and Biological Activities
- Genetic Neurodegenerative Diseases
- Natural product bioactivities and synthesis
Universidad del Noreste
2025
Hong Kong University of Science and Technology
2020-2023
University of Hong Kong
2020-2023
Wuhan University
2021-2022
Second Affiliated Hospital of Zhengzhou University
2022
Thirty compounds including 13 new phenolic glycosides (1-6, 9-15) and 17 known aromatic (7-8, 16-30) were isolated from the roots of Wrightia pubescens. The structures established by extensive NMR spectroscopic data analysis as well chemical derivatization method. evaluated for their hepatoprotective activities using cell model acetaminophen (APAP)-induced HepG2 cells. results indicated that (2, 4, 5, 7, 8, 11, 13) pretreatment enhanced cells viability reduced levels aspartate...
DNA phosphorothioate (PT) modifications, with the nonbridging phosphate oxygen replaced by sulfur, governed DndABCDE or SspABCD, are widely distributed in prokaryotes and have a highly unusual feature of occupying only small portion available consensus sequences genome. Despite presence plentiful non-PT-protected consensuses, PT modification is still employed as recognition tag restriction cognate, for example, DndFGH SspE, to discriminate destroy PT-lacking foreign DNA. This raises...
Maintaining the balance between neuronal excitation and inhibition is essential for proper function of central nervous system. Inhibitory synaptic transmission plays an important role in maintaining this balance. Although inhibitory has higher kinetic demands compared to excitatory transmission, its properties are poorly understood. In particular, dynamics exocytosis single vesicles have not been investigated, due largely both technical practical limitations. Using a combination quantum dots...
How cancer cells respond to different mechanical environments remains elusive. Here, we investigated the tension in single focal adhesions of MDA-MB-231 (metastatic breast cells) and MCF-10A (normal human on substrates varying stiffness using single-cell measurements. Tension measurements an improved FRET-based sensor showed that increased stiffer while exhibited no apparent change against substrate stiffness. Viscoelasticity magnetic tweezers power-law exponent decreased whereas had similar...
Huntington’s disease (HD) is a progressive dominantly inherited neurodegenerative caused by the expansion of cytosine-adenine-guanine (CAG) trinucleotide repeat in huntingtin gene, which encodes mutant protein containing an expanded polyglutamine tract. One neuropathologic hallmarks HD selective degeneration striatum. Mechanisms underlying neurodegeneration striatum remain elusive. Neurodegeneration suggested to be preceded abnormal synaptic transmission at early stage HD. However, how...
Filopodia are slender cellular protrusions containing parallel actin bundles involved in environmental sensing and signaling, cell adhesion migration, growth cone guidance extension. Myosin 10 (Myo10), an unconventional actin-based motor protein, was reported to induce filopodial initiation with its domain. However, the roles of multifunctional tail domain Myo10 formation elongation remain elusive. Herein, we generated several constructs Myo10-full-length Myo10, a truncated (Myo10 HMM), four...
Many biological processes employ mechanisms involving the locations and interactions of multiple components. Given that most occur in three dimensions, simultaneous measurement three-dimensional is necessary. However, precise localization real time remains challenging. Here, we report a new microscopy technique to localize two spectrally distinct particles dimensions with an accuracy (2.35σ) tens nanometers exposure 100 ms measure their real-time using fluorescence resonance energy transfer...
As the key player of a new restriction modification system, DNA phosphorothioate (PT) modification, which swaps oxygen for sulfur on backbone, protects bacterial host from foreign invasion. The identification PT sites helps us understand its physiological defense mechanisms, but accurately quantifying this dynamic remains challenge. Herein, we report simple quantitative analysis method optical mapping in single genome. molecules are fully stretched and immobilized microfluidic chip by...
Abstract Maintaining the balance between neuronal excitation and inhibition is essential for proper function of central nervous system, with inhibitory synaptic transmission playing an important role. Although has higher kinetic demands compared to excitatory transmission, its properties are poorly understood. In particular, dynamics exocytosis single vesicles have not been investigated, due largely both technical practical limitations. Using a combination quantum dots (QDs) conjugated...