A5101595091- Sperm and Testicular Function
- Reproductive Biology and Fertility
- CRISPR and Genetic Engineering
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Radiomics and Machine Learning in Medical Imaging
- Pluripotent Stem Cells Research
- Neuroendocrine regulation and behavior
- RNA regulation and disease
- Plant responses to elevated CO2
- Coronary Artery Anomalies
- Action Observation and Synchronization
- Air Quality Monitoring and Forecasting
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Atmospheric and Environmental Gas Dynamics
- RNA Research and Splicing
- Lepidoptera: Biology and Taxonomy
- Kawasaki Disease and Coronary Complications
- Plant Water Relations and Carbon Dynamics
- Fungal Biology and Applications
- Polysaccharides and Plant Cell Walls
- Hydrogen's biological and therapeutic effects
- Mesenchymal stem cell research
- Psychosomatic Disorders and Their Treatments
- Spider Taxonomy and Behavior Studies
- Pancreatic function and diabetes
Institute of Microbiology
2025
University of Chinese Academy of Sciences
2025
Central South University
2021-2024
Xiangya Hospital Central South University
2021-2024
Peking Union Medical College Hospital
2024
Northwest University
2019-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Northwest A&F University
2017-2023
Yangzhou University
2023
Northern Jiangsu People's Hospital
2022-2023
Abstract Background Mesenchymal stem cells (MSCs) are promising candidates for tissue regeneration and disease treatment. However, long-term in vitro passaging leads to stemness loss of MSCs, resulting failure MSC therapy. This study investigated whether the combination melatonin human umbilical cord mesenchymal (hUC-MSCs) was superior hUC-MSCs alone ameliorating high-fat diet streptozocin (STZ)-induced type II diabetes mellitus (T2DM) a mouse model. Methods Mice were divided into four...
Abstract Orchitis is one of the leading causes male animal infertility and associated with inflammatory reactions caused by bacterium. It has been reported that there a mutual coupling effect between endoplasmic reticulum stress (ERS) response. Our studies showed lipopolysaccharide (LPS) could cause testicular damages, apoptosis, ERS, responses in spermatogonial stem cells (SSCs); ERS‐related apoptosis proteins were activated expression ERS genes was significantly upregulated; meanwhile,...
An unmanned aerial vehicle (UAV) particulate-matter (PM) monitoring system was developed that can perform three-dimensional stereoscopic observation of PM2.5 and PM10 in the atmosphere. The UAV mainly integrated by modules data acquisition processing, wireless transmission, global positioning (GPS). Particularly, this study, a ground measurement-control subsystem added display store collected real time set up measurement scenarios, data-storage modes, sampling frequency as needed. PM...
Abstract Mucopolysaccharidosis type IIIC (MPS IIIC) is one of inherited lysosomal storage disorders, caused by deficiencies in hydrolases degrading acidic mucopolysaccharides. The gene responsible for MPS HGSNAT , which encodes an enzyme that catalyses the acetylation terminal glucosamine residues heparan sulfate. So far, few studies have focused on genetic landscape China, where IIIA and IIIB were major subtypes. In this study, we utilized whole‐exome sequencing (WES) to identify novel...
ABSTRACT Resveratrol (RSV) has been shown to affect the differentiation of several types stem cells, while detailed mechanism is elusive. Here, we aim investigate function RSV in self‐renewal mouse embryonic cells (ESCs) and related mechanisms. In contrast with its reported roles, found unexpectedly that differentiated ESCs or iPSCs treated by would not show further differentiation, but regained a naïve pluripotency state higher expressions core transcriptional factors ability differentiate...
Ganoderic acids (GAs) are a type of highly oxygenated lanostane-type triterpenoids that responsible for the pharmacological activities Ganoderma lucidum. They have been investigated their biological activities, including antibacterial, antiviral, antitumor, anti-HIV-1, antioxidation, and cholesterol reduction functions. Inducer supplementation is viewed as promising technology production GAs. This study found with sodium acetate (4 mM) significantly increased GAs content fruiting bodies by...
We developed and tested an unmanned aerial vehicle-based gas sampling system (UGSS) for collecting gases atmospheric particulate matter (PM). The applies alternative way of both vertical horizontal transects trace in order to analyze them the laboratory. To identify best position UGSS intake port, aerodynamic flow simulations experimental verifications propeller airflow were conducted with vehicle (UAV) hover mode. will automatically replace original from a target location avoid being stored...
Oculocutaneous albinism type 1 (OCA1), resulting from pathogenic variants in the tyrosinase (TYR) gene, refers to a group of phenotypically heterogeneous autosomal recessive disorders characterized by partial or complete absence pigment skin/hair and is also associated with common developmental eye defects. In this study, we identified two novel compound heterozygous TYR Chinese hypopigmentary patient whole-exome sequencing. Specifically, were c.-89T>G, located at core initiator E-box (Inr...
The protein encoded by double sex and mab‐3 related transcription factor 1 (Dmrt1) gene contains a sex/mab‐3 domain, which was considered as one of the most conservative structures in determination. However, its effect on spermatogenesis dairy goat spermatogonial stem cells (SSCs) remains to be clarified. For first time, roles Dmrt1 livestock are highlighted. Here, we investigated expression pattern testes goats. primarily located undifferentiated SSCs. Moreover, enhanced differentiation...
Abundant evidence proves the therapeutic effect of adipose-derived mesenchymal stem cells (ADMSCs) in treatment diabetes mellitus. However, problems have not been solved that viability ADMSCs were inconsistent and quickly undergo senescence after vitro cell culture. In addition, is still satisfactory. this study, melatonin (MLT) was added to canine ADMSC culture medium, treated used treat type 2 mellitus (T2DM). Our research reveals adding MLT medium can promote ADMSCs. This depends on...
Abstract Spermatogenesis is a complex process that originates from and depends on the spermatogonial stem cells (SSCs). The number of SSCs rare, which makes separation enrichment difficult inefficient. transcription factor PAX7 maintains fertility in normal spermatogenesis mice. However, for large animals, much less known about SSCs' self‐renewal regulation, especially dairy goats. We isolated enriched CD49f‐positive negative goat testicular by magnetic‐activated cell sorting strategies....
The diagnostic value of nomogram in pancreatic cancer (PC) with liver metastasis (PCLM) is still largely unknown. We sought to develop and validate a novel for the prediction patients PC.