A5101860410- Nanoplatforms for cancer theranostics
- Luminescence and Fluorescent Materials
- Bone Tissue Engineering Materials
- Covalent Organic Framework Applications
- Nanoparticles: synthesis and applications
- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- Magnesium Alloys: Properties and Applications
- Electrospun Nanofibers in Biomedical Applications
- Chemical Synthesis and Characterization
- Advanced Thermoelectric Materials and Devices
- Nanoparticle-Based Drug Delivery
- Molecular Sensors and Ion Detection
- RNA Interference and Gene Delivery
- Graphene and Nanomaterials Applications
- Blood Coagulation and Thrombosis Mechanisms
- Advanced Nanomaterials in Catalysis
- Metal-Organic Frameworks: Synthesis and Applications
- Advanced biosensing and bioanalysis techniques
- Supramolecular Self-Assembly in Materials
- Orthopaedic implants and arthroplasty
- Acute Myocardial Infarction Research
- Polydiacetylene-based materials and applications
- Osteoarthritis Treatment and Mechanisms
- Tribology and Wear Analysis
Army Medical University
2024
Xinqiao Hospital
2024
Huaiyin Institute of Technology
2017-2024
Chinese Academy of Sciences
2009-2024
Heilongjiang University
2024
Czech Academy of Sciences, Institute of Physics
2024
Sichuan University
2010-2023
University of Hong Kong
2011-2023
Peking University
2011-2023
Center for Life Sciences
2023
Direct electrosynthesis of H2O2 via a two-electron oxygen reduction reaction (2e– ORR) under ambient conditions is emerging as promising solution toward on-site applications for the replacement energy-consuming, waste-intensive, and indirect anthraquinone process. To date, state-of-the-art 2e– ORR catalysis mostly performed with transition-metal-based materials, while main-group element-based catalysts are much less established, which there an urgent need proper understanding. Herein, we...
Background Fucoidan is a sulfated polysaccharide derived from brown algae that has been reported to perform multiple biological activities, including antitumor activity. In this study, we examined the influence of crude fucoidan on mouse breast cancer in vitro and vivo. Materials Methods vitro, fluorescent staining, flow cytometry Western blot were performed analyze apoptosis vascular endothelial growth factor (VEGF) expression 4T1 cells. vivo, therapy experiments conducted Babl/c mice...
Magnesium alloy is considered as one of the ideal cardiovascular stent materials owing to its good mechanical properties and biodegradability. However, in vivo rapid degradation rate insufficient biocompatibility restrict clinical applications. In this study, magnesium (AZ31B) was modified by combining surface chemical treatment in-situ self-assembly 16-phosphonyl-hexadecanoic acid, followed immobilization chitosan-functionalized graphene oxide (GOCS). Heparin (Hep) GOCS were alternatively...
TRPC5 channel is a nonselective cation that participates in diverse physiological processes. inhibitors show promise the treatment of anxiety disorder, depression, and kidney disease. However, binding sites inhibitory mechanism remain elusive. Here, we present cryo-EM structures human complex with two distinct inhibitors, namely clemizole HC-070, to resolution 2.7 Å. The reveal binds inside voltage sensor-like domain each subunit. In contrast, HC-070 wedged between adjacent subunits replaces...
Operating a lithium-ion battery (LIB) in wide temperature range is essential for ensuring stable electricity supply amidst fluctuating temperatures caused by climate or terrain changes. Electrolyte plays pivotal role determining the durability of batteries. However, specialized electrolytes designed either low high typically possess distinct features. Therefore, wide-temperature (WTEs) are necessary as they encompass combination diverse properties, which complicates clear instruction WTE...
Near-infrared fluorescent nanovesicles were prepared by self-assembly of block copolymer hydrophilic poly(ethylene glycol) boron-dipyrromethenes in aqueous solution. The fluorescence enhancement induced dissociation could be used as a smart imaging and diagnostic tool. This nanovesicle encapsulate the antitumor drug, provide powerful platform for imaging-guided tumor-specific drug delivery therapy.
Luminous boron: new 1,8-naphthyridine-BF(2) complexes with strong emissions both in solution and the solid state have been developed. Aggregation-induced blueshifts of DMSO/water mixtures solvent-influenced luminescence crystalline states observed are discussed.
Abstract Caffeic acid (CA), one of the active constituents Radix Salvia miltiorrhiza e, exhibits antioxidant and anti-inflammatory activities. However, few studies have assessed ability CA to inhibit platelet mediated thrombus generation in vivo . In this study, we investigated antithrombotic effect mouse cerebral arterioles venules using intravital microscopy. The antiplatelet activity ADP stimulated platelets vitro was also examined attempt explore underlying mechanism. Our results...
Titanium dioxide nanotube arrays are widely used in biomaterials due to their unique tubular structure and tunable biocompatibility. In the present study, titanium oxide with different diameters were prepared on surface by anodization, followed zinc doping using hydrothermal treatment enhance Both dimensions had obvious influences hydrophilicity, protein adsorption, blood compatibility, endothelial cell behaviors of surface. The increase diameter can improve hydrophilicity could reduce...
Implantation of a scaffold into the body in safe and convenient manner remains challenge repair patient bone defect. In present study, strategy for fabrication redox-sensitive nanofibers with core–shell structure that can deliver growth factors tunable is presented. Poly(ethylene oxide) (PEO) morphogenetic protein 2 (BMP-2) forms inner core region, mixture poly(epsilon-caprolactone) (PCL) redox-responsive c-6A PEG–PCL nanogel −S–S– bond outer shell. The shell respond change GSH (glutathione)...
Osteogenic and antibacterial activities are two basic requirements for orthopedic implants. The present study mainly focused on the investigation of osteoblast behaviors Sr/Ag-incorporated titanium dioxide (TiO2) nanotube array (TNT) surface. To this end, Sr-incorporated TNT was firstly fabricated surface by electrochemical anodization hydrothermal treatment, then Ag nanoparticles (AgNPs) were incorporated onto nanotubes reduction adsorbed Ag+ through ultraviolet (UV) irradiation. TiO2 had...
Abstract Background The misfolding and deposition of amyloid beta (Aβ) in human brain is the main hallmark Alzheimer's disease (AD) pathology. One drivers Alzheimer´s pathogenesis production soluble oligomeric Aβ, which could potentially serve as a biomarker AD. Methods Given that diphenylalanine (FF) at C‐terminus Aβ fragments plays key role inducing AD pathology, based on hydrophobic structure FF, we synthesized near‐infrared BF2‐dipyrrolmethane fluorescent imaging probe (NB) to detect...
While extensive evidence indicates that tumor cells shift their global metabolic programs, the molecular details of transformation in invasion, progression, and metastasis remain largely unknown. Characterization time-dependent during development, will describe an important aspect phenotypes potentially allow us to design therapies inhibit cell movement. In this study, a metabonomic study was performed characterize changes process invasion lung mouse model with subcutaneous transplantation...
LPS-induced microvascular hyperpermeability and hemorrhage play a key role in the development of sepsis, attenuation which might be an important strategy to prevent sepsis. However, current clinical therapies have proven inefficient improving prognosis for patients with Catalpol, iridoid glycoside extracted from roots Rehmannia, has been reported protect against acute lung injury through Toll-like receptor-4 (TLR-4)-mediated NF-κB signaling pathway. it is still unknown whether catalpol can...