A5019852684- Viral Infections and Immunology Research
- Plant Molecular Biology Research
- Synthesis and biological activity
- Metal-Organic Frameworks: Synthesis and Applications
- X-ray Diffraction in Crystallography
- RNA and protein synthesis mechanisms
- Crystallization and Solubility Studies
- Polyoxometalates: Synthesis and Applications
- Plant Reproductive Biology
- Viral gastroenteritis research and epidemiology
- Synthesis and Biological Evaluation
- Vanadium and Halogenation Chemistry
- Plant nutrient uptake and metabolism
- Inflammasome and immune disorders
- COVID-19 Clinical Research Studies
- Plant and Fungal Interactions Research
- Plant Physiology and Cultivation Studies
- Kawasaki Disease and Coronary Complications
- RNA regulation and disease
- Synthesis and properties of polymers
- Research on Leishmaniasis Studies
- Bioactive Compounds and Antitumor Agents
- Thermal Radiation and Cooling Technologies
- Adsorption and Cooling Systems
- Additive Manufacturing and 3D Printing Technologies
Hubei University of Technology
2018-2024
Longgang Central Hospital
2024
Guilin University of Electronic Technology
2024
Northwest A&F University
2019-2021
Jiangnan University
2019
Sichuan Normal University
2017-2018
Chengdu University
2018
Wuhan University
2013-2014
Hubei Academy of Agricultural Sciences
2012-2014
The practical applications of organic phase change materials (PCM) are greatly limited, due to their leakage in the melted state and unacceptably low thermal conductivity.
Enterovirus 71 (EV71) is one of the major causative agents hand, foot, and mouth disease (HFMD), which sometimes associated with severe central nervous system in children. There currently no specific medication for EV71 infection. Quercetin, most widely distributed flavonoids plants, has been demonstrated to inhibit various viral infections. However, investigation anti-EV71 mechanism not reported date.The activity quercetin was evaluated by phenotype screening, determining cytopathic effect...
The coronavirus disease 2019 (COVID-19) global pandemic, caused by severe acute respiratory syndrome type 2 (SARS-CoV-2), has been marked cases demonstrating a “cytokine storm”, an upsurge of pro-inflammatory cytokines in the bloodstream. NLRP3 inflammasomes, integral to innate immune system, are speculated be activated SARS-CoV-2 within host cells. This review investigates potential correlation between inflammasomes and COVID-19, exploring cellular molecular mechanisms through which...
Objective: To develop new Anderson-type polyoxometalates (POMs) with high efficiency and low cytotoxicity, investigate the effects mechanisms against lung (A549), cervical (Hela), breast cancer (MCF7) cell lines. Methods: Cytotoxicity assessments on Hela, A549, MCF-7 tumor cells were tested by MTT assay. Antitumor activities of B1 (vanadium-centered, methyl-modified) B7 hydroxylmodified) detected apoptosis, scratch, colony formation The antitumor molecular explored western blotting. Results:...
The pimprinine family of compounds represent very important and promising microbial metabolites for drug discovery. However, their ability in inhibiting viral infections has not yet been tested.The antiviral activity the was evaluated by determining cytopathic effect (CPE), cell viability or plaque-forming unit (PFU), virus yield. mechanism action against EV71 determined from virucidal activity, effective stage time-of-addition assays. effects on replication were further RNA synthesis,...
A series of dehydroepiandrosterone derivatives containing dihydrazone unit was synthesized via a convenient condensation procedure, and which were evaluated for their potential anticancer activities. The preliminary assays indicated that some the newly compounds exhibited good antitumor activities against human hepatocellular liver carcinoma (HepG2), heptoma (Huh-7), gastric cancer (BGC-823) breast adenocarcinoma (MCF-7) cell lines compared with 5-fluorouracil (5-FU), might be considered as...
Enterovirus 71 (EV71) is a notable causative agent of hand, foot, and mouth disease in children, which associated with an increased incidence severe neurological death, yet there no specific treatment or vaccine for EV71 infections. In this study, the antiviral activity gramine 21 derivatives against was investigated cell-based assays. Eighteen displayed some degree inhibitory effects EV71, that they could effectively inhibit virus-induced cytopathic (CPEs), but anti-EV71 lead compound not...
Coxsackievirus B3 (CVB3) is the most common cause of acute and chronic viral myocarditis, primarily in children, while human adenovirus infections represent a significant morbidity mortality worldwide, people all ages. A series novel 2-benzoxyl-phenylpyridine derivatives were evaluated for their potential antiviral activities against CVB3 type 7 (ADV7). Preliminary assays indicated that some these compounds exhibited excellent effects on both ADV7 viruses; they could effectively inhibit...