A5036331728- Liver Disease Diagnosis and Treatment
- Gastrointestinal disorders and treatments
- Drug Transport and Resistance Mechanisms
- Lipid metabolism and disorders
- Gut microbiota and health
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Diet and metabolism studies
- Liver Diseases and Immunity
- Ferroptosis and cancer prognosis
- Hepatitis C virus research
- Epigenetics and DNA Methylation
- Cancer, Lipids, and Metabolism
- Genomics, phytochemicals, and oxidative stress
- Cannabis and Cannabinoid Research
- Dietary Effects on Health
- AI in cancer detection
- Metabolomics and Mass Spectrometry Studies
- interferon and immune responses
- T-cell and B-cell Immunology
- Child Nutrition and Water Access
- Machine Learning in Bioinformatics
- Cancer Mechanisms and Therapy
- Fibroblast Growth Factor Research
- Genetic factors in colorectal cancer
Zhejiang Chinese Medical University
2020-2025
Sir Run Run Shaw Hospital
2024
Zhejiang University
2024
Integrated Chinese Medicine (China)
2021-2022
Pfizer (United States)
2005
Our previous studies found that Pure total flavnoids from citrus (PTFC) can effectively improve non-alcoholic steatohepatitis (NASH) in mice. Here, we discuss on the mechanism of PTFC treating NASH with focus regulation gut microbiota and bile acid metabolism. C57BL/6 J mice were randomly divided into three groups: normal diet group (Normal), high-fat (HFD) + treatment (PTFC). Mice Normal fed chow diet, while other groups high fat for 16 weeks. In 5th week, treated 50 mg/kg/day an additional...
Gut microbiota (GM) dysbiosis and bile acid (BA) metabolism disorder play an important role in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). Probiotics had a beneficial effect on NAFLD, but further study is needed to explore probiotics as potential therapeutic agent NAFLD. The aim this was investigate regulatory gut NAFLD rats possible mechanism regulating receptor farnesoid X receptor/growth factor 15 (FXR/FGF15) signaling pathway rats. We established rat model fed with...
Objective: To develop new Anderson-type polyoxometalates (POMs) with high efficiency and low cytotoxicity, investigate the effects mechanisms against lung (A549), cervical (Hela), breast cancer (MCF7) cell lines. Methods: Cytotoxicity assessments on Hela, A549, MCF-7 tumor cells were tested by MTT assay. Antitumor activities of B1 (vanadium-centered, methyl-modified) B7 hydroxylmodified) detected apoptosis, scratch, colony formation The antitumor molecular explored western blotting. Results:...
Aim To investigate the treating effect of Yiqi-Bushen-Tiaozhi (YBT) recipe on nonalcoholic steatohepatitis (NASH) mice, determine whether outcome was associated with gut microbiota, and clarify regulating mechanism. Methods NASH mice were induced by high-fat high-fructose diets (HFFD). In fifth week, in YBT group orally administrated (22.12g·kg -1 ·d ) daily for 12 weeks. Fresh stool collected at 16 th week fecal 16S rDNA analysis. Hepatic pathology biochemical indicators used to reflect...
Abstract Background Apoptosis-related genes(Args)play an essential role in the occurrence and progression of hepatocellular carcinoma(HCC). However, few studies have focused on prognostic significance Args HCC. In study, we aim to explore efficient model Asian HCC patients based Args. Methods We downloaded mRNA expression profiles corresponding clinical data from The Cancer Genome Atlas (TCGA) International Consortium (ICGC) databases. were collected Deathbase, a database related cell death,...
San-Huang-Chai-Zhu formula (SHCZF), originates from Da-Huang-Xiao-Shi decoction (DHXSD) for the treatment of jaundice as recorded in Chinese traditional medicine book Jin Gui Yao Lue. In clinic, SHCZF has been used to treat cholestasis-related liver disease by improving intrahepatic cholestasis, but mechanism not elucidated. this study, 24 Sprague-Dawley (SD) rats were randomly assigned normal, acute cholestasis (AIC), SHCZF, and ursodeoxycholic acid (UDCA) groups. addition, 36 SD divided...
Nonalcoholic fatty liver disease (NAFLD) develops rapidly in high-fat diet (HFD) fed Mongolian gerbil ( Meriones unguiculatus). Here, we aim to explore the gene expression characteristics of better understand underlying mechanism this animal model. gerbils were with normal or HFD for different periods. High-throughput sequencing was carried out on hepatic mRNA and bioinformatics analysis further performed. Eight hub genes Cd44, App, Cdc42, Cd68, Cxcr4, Csf1r, Adgre1, Fermt3, which involved...
San-Huang-Chai-Zhu formula (SHCZF) has been used to improve cholestasis for many years. This study aims predict the possible gene targets of SHCZF in treating acute intrahepatic (AIC) rats.Eighteen SD rats were randomly assigned normal group, ANIT and + group. Alpha-naphthylisothiocyanate (ANIT) was induce AIC. Serum biochemical indexes detected each After treatment, livers collected extract RNA. The library constructed by TruSeq RNA, sequenced Illumina, analyzed various bioinformatics...
Shenqi pill (SQP), a famous traditional Chinese medicine (TCM) herbal formula derived from Jinguiyaolue (Synopsis of Prescriptions the Golden Chamber), has long been used to treat kidney yang deficiency syndrome. According TCM treatment principle that liver and are homologies, clinical use SQP in nonalcoholic steatohepatitis (NASH) achieved good effect. However, active targeted genes underlying mechanism remain unclear. In this study, we aimed explore NASH rats, which may further contribute...
The prevalence of NAFLD is increasing annually. early diagnosis and control are crucial for the disease. Currently, metabolic indicators always used clinically as an auxiliary NAFLD. However, not only increased in obese/metabolic-disordered populations. patients with thin body also increasing. Only using to assist may have some deficiencies. Continue develop more clinical diagnostic pressing.Machine learning methods applied capture risk factors 365 adults from Zhejiang Province. Predictive...
In China, the prevalence and mortality of colorectal cancer (CRC) have always been high, more than 95% CRC cases evolved from polyps (CPs), especially adenoma. Early detection treatment CPs through colonoscopy is essential to reduce incidence CRC. Helicobacter pylori (Hp) regarded as a risk factor for gastritis gastric may also be However, few studies based on vast clinical exist in China clarify whether Hp CRC, Hp-positive patients need undergo checks earlier. This article attempts make up...
BACKGROUND:The incidence of breast cancer is increasing annually. Obesity and metabolism are considered risk factors for cancer. Discovery obesity- metabolism-related prognostic genes imminent. MATERIAL AND METHODS:We screened (MRG) from KEGG downloaded the obese female dataset GSE151839 GEO, which differentially-expressed (DEGs), seen as obesity-related genes. The intersection MRGs DEGs was metabolic (OMGs), verified by enrichment analysis. After downloading data TCGA, univariate Cox...