A5049577079- Liver Disease Diagnosis and Treatment
- Trigeminal Neuralgia and Treatments
- Facial Nerve Paralysis Treatment and Research
- Systemic Lupus Erythematosus Research
- RNA modifications and cancer
- Botulinum Toxin and Related Neurological Disorders
- Inflammasome and immune disorders
- NF-κB Signaling Pathways
- Immunotherapy and Immune Responses
- Immune cells in cancer
- Osteoarthritis Treatment and Mechanisms
- Cancer-related molecular mechanisms research
- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Immune Cell Function and Interaction
- Autophagy in Disease and Therapy
- Epilepsy research and treatment
- Glioma Diagnosis and Treatment
- RNA Research and Splicing
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Drug Transport and Resistance Mechanisms
- Pediatric Hepatobiliary Diseases and Treatments
- Endoplasmic Reticulum Stress and Disease
- Fetal and Pediatric Neurological Disorders
Zhejiang Chinese Medical University
2019-2024
Wenzhou Medical University
2021-2022
First Affiliated Hospital of Wenzhou Medical University
2021-2022
Yunnan University
2021
Shanghai First Maternity and Infant Hospital
2017-2018
Shanghai Clinical Research Center
2017
Beijing Shijingshan Hospital
2016
Tsinghua University
2013-2016
Abstract α‐Solanine has been shown to exhibit anti‐inflammatory and anti‐tumour properties; however, its efficacy in treating osteoarthritis (OA) remains ambiguous. The study aimed evaluate the therapeutic effects of α‐solanine on OA development a mouse model. mice were subjected varying concentrations α‐solanine, various assessments implemented assess progression. We found that significantly reduced osteophyte formation, subchondral sclerosis OARSI score. And it decreased proteoglycan loss...
Marijuana is a widely used illicit drug and its consumption during pregnancy has been associated with adverse reproductive outcomes. The purpose of this study was to determine the effects chronic intake Δ9-tetrahydrocannabinol (THC), major component marijuana, on trophoblast function, placental development, birth outcomes.The pathological characteristics distribution cannabinoid receptors in placenta were observed by immunohistochemical (IHC) staining. Cell migration response THC measured...
Gut microbiota (GM) dysbiosis and bile acid (BA) metabolism disorder play an important role in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). Probiotics had a beneficial effect on NAFLD, but further study is needed to explore probiotics as potential therapeutic agent NAFLD. The aim this was investigate regulatory gut NAFLD rats possible mechanism regulating receptor farnesoid X receptor/growth factor 15 (FXR/FGF15) signaling pathway rats. We established rat model fed with...
Low oxygen is a typical extrinsic factor for the regulation of trophoblast biological function, including cell migration, invasion and proliferation. Ten-eleven translocation methylcytosine dioxygenase 1 (TET1), an enzyme converting 5-methylcytosine (5-mC) to 5-hydroxymethylcytosine (5-hmC), transcriptionally activated by hypoxia in cancer cells. Therefore, we focus on role TET1 function physiologically hypoxic environment (3% oxygen), which related early placentation. Here, found that was...
Breast cancer is the most common form of worldwide and a serious threat to women. Hypoxia thought be associated with poor prognosis patients cancer. Long non-coding RNAs are differentially expressed during tumorigenesis can serve as unambiguous molecular biomarkers for breast cancer.Here, we accessed data from The Cancer Genome Atlas model construction performed Gene Ontology Kyoto Encyclopedia Genes Genomes analyses identify biological functions. Four prognostic hypoxia-related lncRNAs...
The aim of this case report and minireview was to investigate the diagnosis therapeutic approaches for angiocentric glioma (AG) summarize clinical manifestations pathological imaging characteristics disease. Intraoperative cortical electroencephalogram (ECoG) monitoring performed locate epileptic foci in a child with AG who presented intractable epilepsy, prior total resection tumor being under microscope. features, characteristics, intraoperative conditions, surgical methods results were...
Preeclampsia (PE) is a pregnancy-specific disorder that the main cause of maternal and perinatal morbidity mortality worldwide. Inadequate trophoblastic invasion endothelial dysfunction in placenta are considered foundation pathogenesis preeclampsia which soluble endoglin (sENG) plays an antiangiogenic role development PE. The leukemia inhibitory factor receptor (LIFR) has been widely studied highly involved arterial injury vivo migration cancer cells vitro Here, we tested hypothesis LIFR...
San-Huang-Chai-Zhu formula (SHCZF) has been used to improve cholestasis for many years. This study aims predict the possible gene targets of SHCZF in treating acute intrahepatic (AIC) rats.Eighteen SD rats were randomly assigned normal group, ANIT and + group. Alpha-naphthylisothiocyanate (ANIT) was induce AIC. Serum biochemical indexes detected each After treatment, livers collected extract RNA. The library constructed by TruSeq RNA, sequenced Illumina, analyzed various bioinformatics...
Inflammatory biomarkers and clinical pathological factors have been reported to predict survival of patients with non-small cell lung cancer (NSCLC). The goal this study was identify risk for early recurrence in pIIIA-N2 NSCLC who had undergone radial resection.A retrospective analysis conducted on 238 underwent surgical treatment at the First Affiliated Hospital Wenzhou Medical University between December 2006 August 2018. (ER) group included recurred within one year curative resection,...
Abstract Recently, the emergence of immunotherapy has revolutionized traditional tumour treatment. However, effective treatments for patients exhibiting αPD-1 resistance are still lacking. In our study, a combination cytosine–phosphate–guanine oligodeoxynucleotides (CpG-ODNs), anti-OX40 and cyclic guanosine monophosphate–adenosine monophosphate (cGAMP) injection in situ systematically generated robust antitumour immune response TC1 B16 cells, which αPD-1-resistant malignancies. More...
Cross talk of tumor–immune cells at the gene expression level has been an area intense research. However, it is largely unknown alternative splicing which found to play important roles in microenvironment. Here, we re-exploited one transcriptomic dataset gain insight into interactions from point AS level. Our results showed that profiles triple-negative breast cancer co-cultured with activated T were significantly changed but not Estrogen receptor positive cells. We further suggested...
Abstract Methods In this study, we developed a strategy for the prevention and therapy of melanoma using whole-cell vaccine combined with CpG/αOX40/cGAMP triple adjuvant. The adjuvant was used to co-culture cells in vitro induce immunogenic death tumor cells. mixture inactivated drug an optimized vaccine, which injected subcutaneously into mice therapy. Furthermore, analyzed changes immune spleen by flow cytometry immunohistochemistry, detected cytokines after application cytometric bead...
Objective The purpose of this research is to find a credible guideline for prognosis and re-exploration Hemifacial spasm.Methods To analyze the data 300 patients with delayed resolution after MVD.Descriptive statistics were performed SPSS 15.0.Results mean time was 129.0 days,M =50.0 days.The 95％ confidence interval(95％ CI) (105.4,152.5) days.Age (P =0.045),course disease =0.029),and post-surgery tic severity ＜ 0.001) significant influences on resolution.Silent period found in 42.7％...
To explore infection rate of different adeno-associated virus (AAV) on knee joint cartilage in mice and to find a good gene editing tool for chondrocytes joint.Forty-five 4-week-old SPF C57BL/6 weighed(14.3±0.2) g were selected. According injections(6 μl) right joint, divided into 9 groups, 5 each group. The groups such as following:control group (normal saline), Vigene 2 (AAV2 from vigene biosciences, titer 1×10¹³ vg/ml), (AAV5 6 (AAV6 7 (AAV7 8 (AAV8 (AAV9 Hanbio DJ group(AAV2-DJ Hanbio,...
Childhood systemic lupus erythematosus (cSLE) is a multisystemic, life-threatening autoimmune disease. Compared to adults, SLE in childhood more active, can cause multisystem involvement including renal, neurological and hematological, cumulative damage across systems rapidly. Autophagy, one of the core functions cells, involved almost every process immune response has been shown be associated with many diseases, being key factor interplay between innate adaptive immunity. Autophagy...