Sepsis is a complex series of immune responses to infection and commonly associated with acquired immunodeficiency. The current study aimed identify the biomarkers sepsis. Differential expression analysis protein-protein interaction were conducted explore potential biomarkers. Gene Ontology enrichment Kyoto Encyclopedia Genes Genomes performed mechanisms. Immune Cell Abundance Identifier website was utilized evaluate cell infiltration in whole blood. Receiver operating characteristic curve...

Background: Exosomes, which carry bioactive RNAs, proteins, lipids, and metabolites, have emerged as novel diagnostic markers therapeutic agents for heart failure (HF). This study aims to elucidate the trends, key contributors, research hotspots of exosomes in HF. Methods: We collected publications related HF from Web Science Core Collection. Using VOSviewer, CiteSpace, Excel, SRplot software, we performed a visualization analysis authors, countries, institutions, keywords, references....

Sepsis-associated coagulopathy (SAC) contributes to the development of multiple organ failure (MOF) and increasing mortality. The present study was conducted investigate whether coagulative biomarkers on admission intensive care unit (ICU) can predict acute kidney injury (AKI) mortality in patients with septic shock caused by intra-abdominal infection (IAI).An observational retrospective surgical ICU. We studied who met criteria (Sepsis-3) IAI between January 1, 2013, December 31, 2016. By...

Septic shock is one of the leading causes mortality in intensive care units. This retrospective study was carried out to evaluate association clinical available factors with 28-day mortality.In this observational study, patients perioperative septic shocks secondary intra-abdominal infection caused by enteric perforation were included. A total 328 sepsis admitted surgical units from January 2012 December 2016. 138 met enrolment criteria and included study. The data demographic, laboratory...

Sepsis is a leading cause of mortality in intensive care units. associated with activation the coagulation cascade and inflammation. The aim this study was to identify coagulation-related genes sepsis that may provide translational potential therapeutic targets. datasets GSE28750, GSE95233, GSE65682 were downloaded from gene expression omnibus database. Consensus-weighted co-expression network analysis (WGCNA) used modules. Gene set enrichment enriched cascade. value hub-gene immunological...

Sepsis is one of the leading causes mortality in intensive care units (ICU). The growing incidence rate sepsis and its high result are very important sociosanitary problems. a infection which can cause systemic inflammatory organ failure. But pathogenesis molecular mechanisms still not well understood. aim present study was to identify candidate key genes progression sepsis.Microarray datasets GSE28750, GSE64457, GSE95233 were downloaded from Gene Expression Omnibus (GEO) database....

The aim of the study was to evaluate efficacy early percutaneous catheter drainage (PCD) for sterile acute inflammatory pancreatic fluid collection (AIPFC) in pancreatitis (AP) varying severity.Retrospective analyses were performed based on presence AIPFC and different AP severities according 2012 Revised Atlanta Classification.Early PCD contributed obvious decreases operation rate (OR, P = 0.006), infection (IR, 0.020), mortality (P 0.009) severe (SAP). In moderate SAP with AIPFCs, however,...

Objective. To probe into the clinical efficacy of tripterygium wilfordii glycoside (TWGs) tablets combined with acitretin capsules in treatment patients moderate to severe plaque psoriasis (MSPP). Methods. Thirty-six MSPP were collected and divided three groups, namely, group A ( <math xmlns="http://www.w3.org/1998/Math/MathML" id="M1"><mi>n</mi><mo>=</mo><mn>12</mn></math> , TWG + capsules), B id="M2"><mi>n</mi><mo>=</mo><mn>12</mn></math> compound glycyrrhizin C...

Guillain-Barré syndrome (GBS) is an acute, immune-mediated inflammatory peripheral polyneuropathy that characterized by flaccid paralysis. A few cases have reported GBS can be caused head trauma or neurosurgery, but it has never been associated with intraventricular hemorrhage. Here, we report uncommon case of fulminant occurred after spontaneous 73-year-old woman was admitted to the hospital sudden unconsciousness and vomiting. computed tomography (CT) scan following incident showed a newly...

Herein, we report a case of an elderly male patient who underwent extended radical resection cardiac carcinoma after regular chemotherapy combined with sintilimab (PD-1 monoclonal antibody) immunotherapy complicated severe pneumonitis postoperatively. We performed several treatments for aspiration pneumonitis; however, the patient's pulmonary infection and oxygenation were not efficiently improved. The multidisciplinary team considered it immune checkpoint inhibitor-associated diagnosis...

Cerebral aspergillosis (CA) is a rare manifestation of invasive aspergillosis. It usually affects seriously immunocompromised hosts. Pancreatic bacterial or/and fungal infection common in patients with severe acute pancreatitis.We report the first case an immunocompetent woman infected necrotizing pancreatitis due to multidrug resistant Acinetobacter baumannii who, course treatment, developed isolated CA.Magnetic resonance imaging, rather than computed tomography, revealed latent homolateral...

Sepsis is a complex clinical syndrome caused by dysregulated host immune response to infection. This study aimed identify competing endogenous RNA (ceRNA) network that can greatly contribute understanding the pathophysiological process of sepsis and determining biomarkers.

<title>Abstract</title> <bold>Background:</bold> Cardiorenal syndrome (CRS) represents a complex interaction between heart failure and renal insufficiency, leading to progressive disease. Type 2 CRS is characterized by the development of dysfunction secondary chronic cardiac The prevalence substantial, af fecting up 45-63% patients admitted for failure. Despite its high morbidity mortality, there lack robust diagnostic tools prognostic models guide clinical management. <bold>Methods:</bold>...

This study aimed to investigate the clinical significance of palliative operation for carcinoma pancreas between bypass surgery and interventional therapy. Most patients with locally advanced pancreatic cancer cannot undergo resection show obstructive jaundice at presentation. Methods palliation in these comprise biliary stent or surgical bypass. We retrospectively analyzed data 53 who underwent treatment incurable ductal adenocarcinoma. retrospective compared morbidity, mortality, hospital...

We report a rare case of 77-year-old man with known left inguinal hernia presenting groin pain following blunt trauma the leg. Diagnosis small bowel perforation away from was obtained only in surgery. Difficulty preoperative diagnosis, rarity histologic pattern, and surgical challenges make this very interesting for surgeons radiologists. Our conclusion upon dealing situation is that diagnosis injury to non-abdominal difficult. The association between may result injuries normally do not...

Abstract Here we report two patients with a car accident injury who suffered cerebral infarction following missed diagnosis of blunt cerebrovascular injury. Difficulty in these cases because no neurological signs or symptoms on initial assessment is lesson for physicians from emergency room. Our conclusion upon dealing the situation that traumatic has potentially devastating consequences. There often delay between trauma and onset deficit. Therefore, clinicians should be cautious this...