A5109465174- Pancreatitis Pathology and Treatment
- Immune Response and Inflammation
- Pancreatic and Hepatic Oncology Research
- Sepsis Diagnosis and Treatment
- Appendicitis Diagnosis and Management
- Antibiotics Pharmacokinetics and Efficacy
- Cardiac, Anesthesia and Surgical Outcomes
- Pediatric Hepatobiliary Diseases and Treatments
- COVID-19 Clinical Research Studies
- Cancer, Stress, Anesthesia, and Immune Response
- Urinary Tract Infections Management
- Immune Cell Function and Interaction
- Clinical Nutrition and Gastroenterology
- Renal function and acid-base balance
- Thermal Regulation in Medicine
- Antibiotic Resistance in Bacteria
- Inflammation biomarkers and pathways
- Respiratory Support and Mechanisms
- Bacterial Identification and Susceptibility Testing
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Neuropeptides and Animal Physiology
- Garlic and Onion Studies
- Calcium signaling and nucleotide metabolism
- Amoebic Infections and Treatments
- Medical Coding and Health Information
Zhejiang University
2014-2025
First Affiliated Hospital Zhejiang University
2019-2025
Second Affiliated Hospital of Zhejiang University
2015-2017
Sir Run Run Shaw Hospital
2014
Wenzhou Medical University
2008-2009
First Affiliated Hospital of Wenzhou Medical University
2008-2009
Abstract Background Sepsis is a critical condition associated with high morbidity and mortality, emphasizing the need for reliable biomarkers its diagnosis prognosis. This study uses advanced immunological techniques to evaluate monocytic CD39 (mCD39) expression as potential marker in sepsis. Methods prospective observational cohort included 206 participants from First Affiliated Hospital, Zhejiang University School of Medicine between April 2022 September 2023. Participants were categorized...
Abstract Sepsis is characterized by a systemic host response to infection. Monocytes, as major mediators of acute infection, are implicated in complications among critically ill patients. Identifying key monocyte subsets and their activation states essential for diagnosis delineating new therapeutic targets sepsis. Here, single cell transcriptome sequencing mass cytometry used assess alterations the composition function peripheral monocytes patients with sepsis, CD38 high circulation...
Severe acute pancreatitis (SAP)-induced intestinal bacterial translocation and enterogenic infection are among the leading causes of mortality in patients. However, mechanisms by which SAP disrupted barrier led to remained unclear. Therefore, we employed multi-omics analysis including microbiome, metabolome, epigenome, transcriptome, mass cytometry (CyTOF) identify potential targets, followed functional validation using transgenic mice. The integrated primarily indicated overgrowth...
Short-peptide-based enteral nutrition (SPEN) is absorbed more efficiently in patients with severe acute pancreatitis (SAP). More importantly, SPEN decreases SAP-induced enterogenous infection risk. This study aims to investigate whether alleviates intestinal bacterial translocation mice SAP, and the underlying mechanisms.The SAP model established after pre-treatment or intact-protein-based nutrition. Although there no improvement pancreas injury, as evaluated through Hematoxylin-Eosin...
The incidence of pneumonia caused by multidrug-resistant gram-negative bacteria (MDR GNB) is increasing, which imposes significant burden on public health. Inhalation combined with intravenous polymyxins has emerged as a viable treatment option. However, pharmacokinetic studies focusing and inhaled polymyxin B (PMB) are limited. This study included seven patients MDR GNB-induced who were treated plus PMB from March 1 to November 30, 2022, in the intensive care unit First Affiliated Hospital...
Malfunctioning of the intestinal microcirculation secondary to severe acute pancreatitis (SAP) can cause injuries mucosal barrier, translocation gut flora, and sepsis. The glycocalyx on vascular endothelium helps maintain its normal function through multiple mechanisms, including regulation permeability inhibition intercellular adhesion. It is unknown that whether inflicts barrier damaging or stabilizing be a potential therapeutic target in maintaining integrity during SAP. Injecting sodium...
Abstract Background: To study the protective effect of Cordyceps sinensis extract (Dong Chong Xia Cao in Chinese [DCXC]) on experimental acute lung injury (ALI) mice. Methods and results: ALI model was induced by intratracheal-instilled lipopolysaccharide (LPS, 2.4 mg/kg) BALB/c male The mice were administrated DCXC (ig, 10, 30, 60 4 8 h after receiving LPS. Histopathological section, wet/dry weight ratio myeloperoxidase activity detected. Bronchoalveolar lavage fluid (BALF) collected for...
Nirmatrelvir/ritonavir is a highly efficacious agent against severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) infection. Although dose adjustment recommended in patients with renal impairment according to the package insert of Paxlovid (Pfizer), there no recommendation for who need continuous replacement therapy (CRRT). To characterize features nirmatrelvir/ritonavir critically ill Chinese undergoing CRRT, therapeutic drug monitoring was applied by high-performance liquid...
Delayed gastric emptying (DGE) in patients with acute pancreatitis (AP) can be caused by gastroparesis or outlet obstruction, which may occur when pancreatic pseudocyst (PP) walled-off necrosis (WON) compresses the stomach. The aim of study was to explore a proper surgical treatment.From June 2010 2013, 25 148 AP suffered DGE. Among them, 12 were gastroparesis, 1 result obstruction from Candida albicans plug, and (GOO) compressed PP (n = 8) WON 4), treated percutaneous catheter drainage...
Septic shock is one of the leading causes mortality in intensive care units. This retrospective study was carried out to evaluate association clinical available factors with 28-day mortality.In this observational study, patients perioperative septic shocks secondary intra-abdominal infection caused by enteric perforation were included. A total 328 sepsis admitted surgical units from January 2012 December 2016. 138 met enrolment criteria and included study. The data demographic, laboratory...
There is a critical need for rapid and sensitive pathogen detection method septic patients. This study aimed to investigate the diagnostic efficacy of Digital droplet polymerase chain reaction (ddPCR) in identifying pathogens among suspected
Increasing shortage of intensive care resources is a worldwide problem. While routine postoperative admission to the unit (ICU) patients undergoing neurosurgery long established practice for many hospitals. Therefore, some neurosurgical have be cared in post anesthesia (PACU) before ICU during high occupancy. The aim this study was compare outcome immediately admitted operation with those who were required wait bed PACU and managed by anesthesiologists admission. All adult our between...
Background: Delayed treatment of seriously infected patients results in increased mortality. However, antimicrobial therapy for the initial 24 to 48 hours is mostly empirically provided, without evidence regarding causative pathogen. Whether empiric anti-enterococcal should be administered treat intra-abdominal infection (IAI) before obtaining culture remains unknown. We performed a meta-analysis explore effects enterococci covered antibiotic IAI and risk factors enterococcal IAI. Methods:...
The majority of patients with COVID-19 showed mild symptoms. However, approximately 5% them were critically ill and require intensive care unit admission for advanced life supports. Patients in the high risk venous thromboembolism hemorrhage due to immobility anticoagulants used during aim study was report incidence treatments two complications such patients.Patients (Group 1) community-acquired pneumonia 2) that required enrolled this retrospective study. Their demographics, laboratory...
Sepsis is one of the leading causes mortality in intensive care units (ICU). The growing incidence rate sepsis and its high result are very important sociosanitary problems. a infection which can cause systemic inflammatory organ failure. But pathogenesis molecular mechanisms still not well understood. aim present study was to identify candidate key genes progression sepsis.Microarray datasets GSE28750, GSE64457, GSE95233 were downloaded from Gene Expression Omnibus (GEO) database....
Chylous ascites (CA) may be involved in the pathological process of severe acute pancreatitis (SAP), but underlying mechanisms remain unknown. This study investigated incidence CA patients with SAP and its relationship enteral nutrition (EN).A retrospective review 85 admitted to our hospital was performed. Patients starting EN within 72 hours after onset were classified as early (EEN) group, others, later group. The incidences prognosis EEN groups examined preparation polymeric formula or...
The aim of the study was to evaluate efficacy early percutaneous catheter drainage (PCD) for sterile acute inflammatory pancreatic fluid collection (AIPFC) in pancreatitis (AP) varying severity.Retrospective analyses were performed based on presence AIPFC and different AP severities according 2012 Revised Atlanta Classification.Early PCD contributed obvious decreases operation rate (OR, P = 0.006), infection (IR, 0.020), mortality (P 0.009) severe (SAP). In moderate SAP with AIPFCs, however,...