This study aims to investigate the characteristics of hearing loss associated with MYO15A mutations and analyze longitudinal prognosis over a 4-year period using different treatment modalities, including cochlear implants (CIs), aids (HAs), conservative management. A retrospective case review. tertiary referral center. Sequencing was performed recruit patients potentially pathogenic mutation-induced loss. Audiological data, radiological imaging, assessment speech performance before after...

Enterovirus 71 (EV71) is the major pathogen of hand, foot, and mouth disease can cause death; however, its pathogenesis remains elusive.We performed a detailed systematic histopathologic examination molecular studies on six autopsy cases EV71 infection using H&E, immunohistochemistry, double immunofluorescence staining, nested reverse transcription polymerase chain reaction.Characteristic features acute encephalomyelitis were observed. Viral antigens mainly detected in neuronal cytoplasm...

The advance of tunnel shield creates void between the lining segments and surrounding rock at tail part shield. Grout is continuously injected into that void, to control ground subsidence maintain stability. grouting process must be precisely controlled monitored prevent any undesired significant or segment damage. In this work, a novel model characterise temporal spatial distribution grout pressure in rock-segment proposed, based on theory group diffusion consolidation. variation viscosity...

Tinnitus is a common disease, and sound therapy an effective method to alleviate it. Previous studies have shown that notched not only changes levels of cortical blood oxygen, but affects oxygen in specific cerebral areas, such as Brodmann area 46 (BA46), which associated with emotion. Extensive evidence has confirmed tinnitus closely related Whether plays role regulating the emotional center still unclear.This study included 29 patients newly diagnosed chronic who were treated sound....

Many hearing-impaired patients carry mutations in rare or novel genes undetected regular genetic hot regions/genes screening.We collected clinical and data from subjects with hearing loss who visited our department for counseling. Next-generation sequencing was conducted after 154 deafness-related were captured using a designed panels 14 unrelated families (37 participants). The results filtered assessed silico tools, combination pedigree mapping.Ten deafness (GJB2, SLC26A4) uncommon (OTOF,...

Mutations in the cadherin 23 gene (CDH23) have been reported to cause cochlear damage, but few studies investigated auditory and speech outcome of patients after implantation. Here, we describe genetic, auditory, postoperative outcomes with CDH23 mutations who received implants.Retrospective case review.Tertiary referral center.Targeted deafness-related panels were sequenced Chinese families profound sensorineural hearing loss. The clinical features subjects carrying potentially pathogenic...

In order to fully explore and analyze the inherent law of power load data improve prediction accuracy residents' daily electricity consumption, because analysis comparison multiple forecasting methods, radial basis function (RBF) neural network algorithm with introduction clustering idea is used in this paper. The historical maximum temperature are chosen cluster by k-means algorithm, according change rule example correlation between other attributes, such as temperature, weather, holiday....

Epidemiological evidence has shown that smoking is associated with an increased risk of hearing loss. However, the underlying mechanisms regarding impact nicotine on cochlea remain unclear. This study aimed to investigate cytotoxic effects cochlear cells using cultured basilar membranes. Cochlear membranes were isolated from newborn rats, cultured, and treated 1-100 ng/mL for 48 h. Cuticular plates stereocilia bundle staining used evaluate hair cell (HC) Spiral ganglion neuron acoustic nerve...

Abstract Background The 2013 ACC/AHA Guideline was a paradigm shift in lipid management and identified the four statin-benefit groups. Many have studied guideline’s potential impact, but few investigated its long-term impact on MACE. Furthermore, most studies also ignored confounding effect from earlier release of generic atorvastatin Dec 2011. Methods To evaluate (long-term) Nov U.S., we association with trend changes 5-Year MACE survival three other statin-related outcomes (statin use,...

The ONR project “Application of an Empirical Mode Decomposition (EMD) detection and classification process to environments for Naval monitoring detection” created empirical variational mode decomposition analysis workflows detect cluster diverse underwater signals across four distinct datasets. Twenty-five call types from the Bering Chukchi Seas, Aeon’s North Atlantic sites, CTBTO hydroacoustic stations, Chambal River were detected clustered with varying levels success. final precision,...

This study aims to identify the genetic etiology underlying late-onset hearing loss in two unrelated Chinese families.

Objectives The relationship between the middle temporal (MTG) and occipital cortices in post‐lingually deaf (PLD) individuals is unclear. This study aimed to investigate changes MTG excitability their effects on cortex with PLD after receiving a cochlear implant (CI). Methods Twenty‐six severe‐to‐profound binaural sensorineural were assessed clinically. Nine had received unilateral over 6 months, while 17 not. Brodmann area 19 (BA19, extra‐striate cortex) (auditory‐related of selected as...

A quantitative assessment for measuring the placenta during gross examination is a crucial step in evaluating health status of both mother and fetus. However, current clinical practice, time-consuming observer-variant drawbacks are caused due to manual measurement subjective determination placental characteristics. Therefore, we propose system efficiently accurately characteristics according Amsterdam Consensus, including weight thickness placenta, length width disc, diameter umbilical cord,...

Risso's and Pacific white-sided dolphins occupy similar habitats have been acoustically documented in northward habitat expansion above the Aleutian archipelago. Therefore, being able to differentiate between two, either more easily during manual analysis or through automation, is important track their distribution estimate population densities. In our previous work, a semi-blind detection classification (SDC) process based on Empirical Mode Decomposition (EMD) showed promise for detecting...

Objective To investigated the changes of angiopoietin-like protein 2(Angptl2) in patients with arteriosclerotic occlusion (ASO). Methods A total 140 subjects including 75 ASO (ASO group) and 65 healthy (control were enrolled this study. Angptl2 adiponectin evaluated by using enzyme-linked immunosorbent assay. Biochemical data high sensitive C reactive measured recorded as well. Results Compared to control group,the group presented significantly higher level plasma [(13.55±9.17) μg/L vs....

Improve the prediction accuracy of fire situation reasonably has great significance for prevention and deployment. Firstly, build a model by using support vector regression; followed adopt genetic algorithm to select optimal combination parameters; finally provide empirical analysis taking Chinese Zhejiang Province, test reliability practicality model. The results showed that: based on machine ideal learning ability generalization ability; predicted possess high precision, thus providing new...

To investigate the changes and value of plasma angiopoietin-related growth factor (AGF) in patients with abdominal aortic aneurysm (AAA).Serum AGF level was analyzed 50 AAA 56 healthy subjects. adiponectin were quantified by enzyme-linked immunosorbent assay. Routine testing blood biochemistry high-sensitivity C-reactive protein performed.The significantly higher than controls [(87.91±96.87) μg/L vs. (56.89±41.32) μg/L, P=0.040],while serum showed no significant difference between these two...

Abstract Tracking species with expanding ranges is crucial to conservation efforts and some typically temperate marine are spreading northward into the Arctic Ocean. Risso’s (Gg) Pacific white-sided (Lo) dolphins have been documented poleward. Further, they make very similar sounds, so it difficult for both human analysts classification algorithms tell them apart. Using automatic detectors classifiers on large acoustic datasets would improve efficiency of monitoring these species....

West Oil Product pipeline always take batch transportation, conveying three different qualities of oil product.Crude takes a task transportation from oilfields in Xinjiang.In accordance with the principles higher prices for better quality crude oil, it finally.The paper 10m three-dimensional vertical pipe as carrier.It two kinds alternative upward or downward.When transport order, gravity, temperature are different, order to reduce volume mixing and optimize program, we have concentration...