A5100679434- Ocular Surface and Contact Lens
- Glaucoma and retinal disorders
- Meteorological Phenomena and Simulations
- Corneal Surgery and Treatments
- Liver Disease Diagnosis and Treatment
- Ophthalmology and Visual Impairment Studies
- Ocular and Laser Science Research
- Cryptographic Implementations and Security
- Tropical and Extratropical Cyclones Research
- Coding theory and cryptography
- Meta-analysis and systematic reviews
- Research on Leishmaniasis Studies
- Retinal Diseases and Treatments
- Millimeter-Wave Propagation and Modeling
- Lung Cancer Diagnosis and Treatment
- Imbalanced Data Classification Techniques
- Full-Duplex Wireless Communications
- Graphene and Nanomaterials Applications
- Phytochemicals and Antioxidant Activities
- Health, Environment, Cognitive Aging
- Ocular Infections and Treatments
- Vitamin C and Antioxidants Research
- Parasites and Host Interactions
- melanin and skin pigmentation
- Cancer Research and Treatment
Allergan (United States)
2013-2024
AbbVie (United States)
2023-2024
Shanxi Medical University
2023
Cangzhou Central Hospital
2020-2021
Central South University
2020
Nanjing University of Chinese Medicine
2019
Roche (China)
2018
Beijing University of Chinese Medicine
2017
North China University of Science and Technology
2017
Harbin Medical University
2009-2017
Tear film instability and tear hyperosmolarity are considered core mechanisms in the development of dry eye. The authors hypothesize that evaporation produce transient shifts lead to chronic epithelial stress, inflammation, symptoms ocular irritation. purpose this study was provide indirect evidence short-term hyperosmolar conditions during test whether corneal epithelium responds stress.Five subjects kept one eye open as long possible, overall discomfort sensations associated with break-up...
To evaluate the safety, efficacy, and pharmacokinetics of pilocarpine hydrochloride 1.25% (Pilo hereafter) compared with vehicle when administered bilaterally, twice daily (6 hours apart) for 14 days in participants presbyopia.Phase 3, randomized (1:1), controlled, double-masked, multicenter study.Participants (40-55 years age) had objective subjective evidence presbyopia affecting activities mesopic, high-contrast, binocular distance-corrected near visual acuity (DCNVA) 20/40 to 20/100. The...
The purpose of this study was to test the association between tear film fluorescence changes during break-up (TBU) or thinning and concurrent ocular sensory response.Sixteen subjects kept one eye open as long possible (MBI), indicated their discomfort level continuously, rated sensations irritation, stinging, burning, pricking, cooling using visual analog scales (VAS). Fluorescence quantified by a pixel-based analysis median pixel intensity (PI), TBU, percentage dark pixels (DarkPix) over...
Diffusion models have indeed shown great promise in solving inverse problems image processing. In this paper, we propose a novel, problem-agnostic diffusion model called the maximum posteriori (MAP)-based guided term estimation method for problems. We divide conditional score function into two terms according to Bayes' rule: unconditional and term. design MAP-based method, while is approximated by an existing network. To estimate term, base on assumption that space of clean natural images...
Rhodesain (RD) is a parasitic, human cathepsin L (hCatL) like cysteine protease produced by Trypanosoma brucei ( T. b.) species and potential drug target for the treatment of African trypanosomiasis (HAT). A library hCatL inhibitors was screened, macrocyclic lactams were identified as potent RD Ki < 10 nM), preventing cell-growth rhodesiense (IC50 400 nM). SARs addressing S2 S3 pockets established. Three cocrystal structures with revealed noncovalent binding mode this ligand class due to...
Changes in the intestinal flora are related to autoimmune hepatitis (AIH) development. The aim of this study is investigate synergistic effects probiotics and prebiotics on liver injury induced by concanavalin A (Con A).C57BL/6 mice fed (Pro), (Pre), synbiotic (Syn) for 7 days then Con injected via tail veins induce AIH. Additionally, methylprednisolone (MP) gavaged 0.5 h after injection. It found that both Pro, Pre, Syn, MP decrease levels serum transaminase, F4/80+ macrophage cells,...
To evaluate the efficacy and safety of a nano-emulsion artificial tear (OM3) containing carboxymethylcellulose (CMC) glycerin, flaxseed oil castor oil, three osmoprotectants (levocarnitine, erythritol, trehalose) compared with an (Refresh Optive Advanced [ROA]) same ingredients exception trehalose oil. In this multicenter, double-masked, randomized, two-arm, parallel-group, 6-visit study (screening, baseline, days 7, 30, 60, 90), subjects dry eye disease underwent open-label, 7-day run-in...
This study aimed to identify biomarkers for predicting the prognosis of advanced gastric cancer patients who received docetaxel, cisplatin, and S-1 (DCS).Gene expression profiles were obtained from Gene Expression Omnibus database (GSE31811). Gene-Ontology-enrichment KEGG-pathway analysis used evaluating biological functions differentially-expressed genes. Protein-protein interaction (PPI) network Kaplan-Meier survival analyses employed assess prognostic values hub genes.A total 1,486...
Purpose: This study aimed to explore protective effects and potential mechanism of ectoine, a natural osmoprotectant, on ocular surface mucin production in dry eye disease. Methods: A model was established C57BL/6 mice exposed desiccating stress (DS) with untreated (UT) as controls. DS were topically treated 2.0% ectoine or PBS vehicle. Corneal epithelial defects assessed by Oregon Green Dextran (OGD) fluorescent staining. Conjunctival goblet cells, mucins, T help (Th) cytokines evaluated...
Abstract The 12–13 June 2002 convective initiation case from the International H2O Project (IHOP_2002) field experiment over central Great Plains of United States is simulated numerically with Advanced Regional Prediction System (ARPS) at 3-km horizontal resolution. involves a developing mesoscale cyclone, dryline extending low center southwestward cold front closely behind, which intercepts midsection dryline, and an outflow boundary stretching eastward resulting earlier convection....
The goal of this study was to evaluate the actual anatomical and dosimetric changes parotid glands in nasopharyngeal carcinoma patients during intensity modulated radiation therapy. With helical tomotherapy, its planning system, adaptive software, weekly 35 NPC were evaluated. Interweekly volume varied significantly (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn>0.03</mml:mn></mml:math>). rate change reached highest level at...
Abstract Anisotropic recursive filters are implemented within a three-dimensional variational data assimilation (3DVAR) framework to efficiently model the effect of flow-dependent background error covariance. The covariance is based on an estimated field and idea Riishøjgaard. In anisotropic case, pattern can be stretched or flattened in directions oblique alignment grid coordinates constructed by applying, at each point, six along corresponding, general, special configuration lines grid....
Clinical relevance Patients prescribed pilocarpine ophthalmic solution are advised to be cautious when driving at night, but studies evaluating the effects of hydrochloride 1.25% (pilo), approved treat presbyopia, on night lacking.
Neural collapse, a newly identified characteristic, describes property of solutions during model training. In this paper, we explore neural collapse in the context imbalanced data. We consider $L$-extended unconstrained feature with bias term and provide theoretical analysis global minimizer. Our findings include: (1) Features within same class converge to their mean, similar both balanced case without bias. (2) The geometric structure is mainly on left orthonormal transformation product $L$...
It aimed to explore the application value of high-frequency ultrasound image based on wavelet bilateral filtering algorithm in repair evaluation hypertrophic scar and keloid, as well expression change nerve growth factor (NGF). 72 patients with scars admitted hospital from October 2018 2019 were chosen classified (group A) keloid B), 36 cases each group. All received treatment, another 30 normal skin volunteers C) selected. High-frequency images filter utilized for examination. The...
// Fanling Meng 1, * , Haixia Liu Shuang 1 and Rong Ma Department of Gynecology, Harbin Medical University Cancer Hospital, Harbin, China These authors have contributed equally to this work Correspondence to: Ma, email: dr_marong2017@126.com Keywords: hematopoietic pre-B-cell leukemia transcription factor-interacting protein, HPIP, cervical cancer, metastasis, prognosis Received: April 11, 2017 Accepted: June 20, Published: July 26, 2017 ABSTRACT Hematopoietic...