A5100646958- Radiation Therapy and Dosimetry
- Radiation Detection and Scintillator Technologies
- Advanced Radiotherapy Techniques
- Nuclear Physics and Applications
- Radiation Dose and Imaging
- Medical Imaging Techniques and Applications
- Advanced X-ray and CT Imaging
- Quantum Mechanics and Applications
- Quantum Information and Cryptography
- Nuclear reactor physics and engineering
- Radioactivity and Radon Measurements
- Digital Radiography and Breast Imaging
- Radioactive contamination and transfer
- Particle Detector Development and Performance
- Graphite, nuclear technology, radiation studies
- Quantum Computing Algorithms and Architecture
- AI in cancer detection
- Laser-Plasma Interactions and Diagnostics
- Effects of Radiation Exposure
- Particle physics theoretical and experimental studies
- Electron and X-Ray Spectroscopy Techniques
- Advanced Thermodynamics and Statistical Mechanics
- Dark Matter and Cosmic Phenomena
- Neutrino Physics Research
- Atomic and Subatomic Physics Research
Tsinghua University
2016-2025
Sichuan Normal University
2023-2024
Ludong University
2024
Ministry of Education of the People's Republic of China
2016-2024
Sun Yat-sen University
2023-2024
University of Chinese Academy of Sciences
2007-2023
City University of Hong Kong
2023
National Yang Ming Chiao Tung University
2023
Tongji University
2023
Shanghai Jiao Tong University
2023
We present new constraints on light dark matter boosted by cosmic rays (CRDM) using the 205.4 kg day data of CDEX-10 experiment conducted at China Jinping Underground Laboratory. The Monte Carlo simulation package CJPL\_ESS was employed to evaluate Earth shielding effect. Several key factors have been introduced and discussed in our CRDM analysis, including contributions from heavier CR nuclei than proton helium, inhomogeneity distribution, impact form factor attenuation calculation. Our...
The cellular response to ionizing radiation continues be of significant research interest in cancer radiotherapy, and DNA is recognized as the critical target for most biologic effects radiation. Incident particles can cause initial damages through physical chemical interactions within a short time scale. Initial undergo repair via different pathways available at stages cell cycle. misrepair damage results genomic rearrangement causes mutations chromosome aberrations, which are drivers...
Abstract Uncertainty principle is one of the cornerstones quantum theory. In literature, there are two types uncertainty relations, operator form concerning variances physical observables and entropy related to entropic quantities. Both these forms inequalities involving pairwise found be nontrivial incorporate multiple observables. this work we introduce a new relation which may give out complete trade-off relations for in pure mixed systems. Unlike prevailing either state dependent or not...
In the heavy ion therapy, not only distribution of physical absorbed dose, but also relative biological effectiveness (RBE) weighted dose needs to be taken into account. The microdosimetric kinetic model (MKM) can predict RBE value ions with saturation-corrected dose-mean specific energy, which has been used in clinical treatment planning at National Institute Radiological Sciences. theoretical assumption MKM, yield primary lesion is independent radiation quality, while experimental data...
Microdosimetric energy depositions have been suggested as a key variable for the modeling of relative biological effectiveness (RBE) in proton and ion radiation therapy. However, microdosimetry has underutilized Recent advances detector technology allow design new mico- nano-dosimeters. At same time Monte Carlo (MC) simulations become more widely used In order to address growing interest field, microdosimetric extension was developed TOPAS. The provides users with functionality simulate...
Monte Carlo (MC) track structure simulation tools are commonly used for predicting radiation induced DNA damage by modeling the physical and chemical reactions at nanometer scale.However, outcome of these MC simulations is particularly sensitive to adopted parameters which vary significantly across studies.In this study, a previously developed full model nuclear was describe geometry.The TOPAS-nBio toolkit investigate impact physics chemistry models as well three key (the energy threshold...
Abstract Purpose The ultra-high dose rate (UHDR) radiation shows promise in eradicating tumors while reducing normal tissue toxicities. However, the biological outcomes of UHDR are influenced by various factors, particularly mean and instantaneous rate. Additionally, response at large field sizes is lacking. This study aimed to explore impact different combinations on gastrointestinal following total-body irradiations (TBI) examine involved molecular signaling pathways. Method Female...
The target theory is the most classical hypothesis explaining radiation-induced cell death, yet physical or biological nature of “target” remains ambiguous. This study hypothesizes that distribution DNA double-strand breaks (DSBs) within 3D genome a pivotal factor affecting probability death. We propose clustered DSBs in segments with high-interaction frequencies are more susceptible to leading death than isolated DSBs. Topologically associating domains (TAD) can be regarded as reference...
A mechanistic model of cellular survival following radiation-induced DNA double-strand breaks (DSBs) was proposed in this study. DSBs were assumed as the initial lesions cell nucleus induced by ionizing radiation. The non-homologous end-joining (NHEJ) pathway considered domain DSB repair mammalian cells. to predict relationship between and probability survival, which quantitatively described two input parameters six fitting parameters. One parameter average number primary particles caused...
Purpose FLASH (ultra-high dose rate) radiotherapy spares normal tissue while keeping tumor control. However, the mechanism of effect remains unclear and may have consequences beyond irradiated area.Materials methods We reanalyze available results ultra-high-dose-rate-related experiments to find out key points effect. Then, we present a hypothesis on effect: beams generate high transient concentration peroxyl radicals leading fraction radical recombination, which in less oxidation damage...
The method of Monte Carlo simulation is a powerful tool to investigate the details radiation biological damage at molecular level. In this paper, code called NASIC (Nanodosimetry Simulation Code) was developed. It includes physical module, pre-chemical chemical geometric module and DNA module. can simulate tracks low-energy electrons in liquid water event-by-event. More than one set inelastic cross sections were calculated by applying dielectric function Emfietzoglou's optical-data...
Purpose: Recent studies suggest ultra-high dose rate (FLASH) irradiation can spare normal tissues from radiotoxicity, while efficiently controlling the tumor, and this is known as FLASH effect. This study performed theoretical analyses about impact of radiolytic oxygen depletion (ROD) on cellular responses after irradiation. Methods: Monte Carlo simulation was used to model ROD process, determine DNA damage, calculate amount depleted (LROD) during exposure. A mathematical applied analyze...
A high-resolution whole-body voxel model called CAM representing the Chinese adult male was constructed in this paper based on a previous individual model. There are more than 80 tissues and organs CAM, including almost all required ICRP new recommendation. The mass of has been adjusted to reference data. Special considerations were given gross spatial distribution various bone constituents as realistically possible during construction site-specific skeleton. Organ dose conversion...
The uncertainty relation is a distinguishing feature of quantum theory, characterizing the incompatibility noncommuting observables in preparation states. Recently, many relations were proposed with improved lower bounds and deemed capable incorporating multiple observables. Here we report an experimental verification seven this type single-photon measurements. results, while confirming these relations, show as well relative stringency various bounds.
Uncertainty relation lies at the heart of quantum mechanics, characterizing incompatibility non-commuting observables in preparation states. An important question is how to improve lower bound uncertainty relation. Here we present a variance-based sum for $N$ incompatible stronger than simple generalization two derived by Maccone and Pati [Phys. Rev. Lett. {\bf113}, 260401 (2014)]. Further comparisons our with other related ones spin-$\frac{1}{2}$ spin-$1$ particles indicate that obtained...
In vivo measurement is a main method of internal contamination evaluation, particularly for large numbers people after nuclear accident. Before the practical application, it necessary to obtain counting efficiency detector by calibration. The virtual calibration based on Monte Carlo simulation usually uses reference human computational phantom, and morphological difference between monitored personnel with calibrated phantom may lead deviation efficiency. Therefore, library containing wide...
Purpose Oxygen plays a crucial role in radiation biology. Antioxidants and peroxyl radicals affect the oxygen effect greatly. This study aims to establish computational model of explore attributed antioxidants radicals.