A5080196425- Congenital Heart Disease Studies
- Congenital Diaphragmatic Hernia Studies
- Head and Neck Cancer Studies
- RNA modifications and cancer
- Tracheal and airway disorders
- Birth, Development, and Health
- Lung Cancer Treatments and Mutations
- Pectus Deformity Diagnosis and Treatment
- Congenital heart defects research
- Cardiovascular and Diving-Related Complications
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Aortic Disease and Treatment Approaches
- Phonocardiography and Auscultation Techniques
- Cardiac Valve Diseases and Treatments
- Management of metastatic bone disease
- Vascular anomalies and interventions
- Radiomics and Machine Learning in Medical Imaging
- Health, Environment, Cognitive Aging
- Ear and Head Tumors
- Glioma Diagnosis and Treatment
- Anatomy and Medical Technology
- Brain Metastases and Treatment
- Health disparities and outcomes
- Renal and Vascular Pathologies
Chongqing Medical University
2024-2025
Children's Hospital of Zhejiang University
2012-2025
Jiangxi University of Traditional Chinese Medicine
2025
Jiangsu University of Science and Technology
2025
Children's Hospital of Chongqing Medical University
2025
Zhejiang University
2002-2024
Hangzhou Medical College
2024
Second People's Hospital of NanTong
2024
Nantong University
2024
Guangzhou Medical University
2023
N 6-methyladenosine (m6A) modification of RNA is deposited by the methyltransferase complex consisting Mettl3 and Mettl14 erased demethylase Fto Alkbh5 involved in diverse biological processes. However, it remains largely unknown specific function mechanism regulating adult neural stem cells (aNSCs). In present study, utilizing a conditional knockout (cKO) mouse model, we show that ablation aNSCs transiently increases proliferation promotes neuronal differentiation both vitro vivo, but long...
To report the treatment outcomes and complication rates of stereotactic radiotherapy in management patients with juxtapapillary choroidal melanoma.A retrospective review 64 consecutive melanoma, located within 2 mm optic disc, treated at Princess Margaret Hospital between October 1998 January 2006.The median age was 63 years. The tumour height 4.2 mm, largest basal diameter 9.8 mm. prescribed radiation dose 70 Gy five fractions over 10 days, follow-up 37 months. Post-treatment, actuarial...
The coronavirus disease 2019 (COVID-19) has caused a global pandemic. All people including children are generally susceptible to COVID-19, but the condition is relatively mild for children. diagnosis of COVID-19 largely based on epidemiological evidence and clinical manifestations, confirmed by positive detection virus nucleic acid in respiratory samples. main symptoms fever cough; total number white blood cell count usually normal or decreased; chest imaging characterized interstitial...
Background Developmental dysplasia of the hip (DDH) is a common orthopedic disease in children. In clinical surgery, it essential to quickly and accurately locate exact position lesion, there are still some controversies relating DDH status. We adopt artificial intelligence (AI) solve above problems. Methods this paper, automatic measurements classifications were achieved using three-stage pipeline. first stage, we used Mask-RCNN detect local features image segment bony pelvis, including...
Abstract Zinc-based alloys have attracted increasing interest as absorbable implant metals due to their suitable degradation rate and biocompatibility. However, a high concentration of Zn 2+ the process results in cytotoxicity, low osteogenesis remains problem. In this work, compact coating well integrated into substrate was fabricated on surface zinc via micro-arc oxidation (MAO). The is mainly composed ZnO. addition phosphate reinforced adhesive strength between coating. Electrochemical...
Zinc plays a critical role in cellular functions, but its excess may lead to detrimental effects, including cardiac abnormalities. The impact of zinc overload on cardiomyocytes is investigated this study. For the first time, we report regulatory relationship between and histone acetylation. Excessive downregulates transcription Bmp4 HL-1 cell line primary cardiomyocytes. This downregulation linked reduced acetylation (H3K9ac), mediated by suppression acetyltransferases (HATs), rather than...
This investigation assesses the perinatal risks associated with different clinical subtypes of intrahepatic cholestasis pregnancy (ICP) based on symptomatology, goal informing optimal delivery timing for each specific ICP subtype. The retrospective study encompassed 2,057 singleton pregnancies ICP, categorized into single-symptomatic (ICP-S) and multisymptomatic (ICP-M) groups. ICP-M group was further subdivided symptom combinations: elevated TBA transaminases (ICP-MT), pruritus (ICP-MP),...
Background: Congenital heart disease (CHD) is a common birth defect in children. Intelligent auscultation algorithms have been proven to reduce the subjectivity of diagnoses and alleviate workload doctors. However, development this algorithm has limited by lack reliable, standardized, publicly available pediatric sound databases. Therefore, objective research develop large-scale, high-standard, high-quality, accurately labeled congenital database, perform classification tasks evaluate its...
Abstract The ten-eleven translocation (Tet) family of dioxygenases convert 5-methylcytosine to 5-hydroxymethylcytosine (5hmC). Previous studies have shown that 5hmC-mediated epigenetic modifications play essential roles in diverse biological processes and diseases. Here, we show Tet proteins 5hmC display dynamic features during postnatal cardiac development Tet2 is the predominant dioxygenase present heart. knockout results abnormal function, progressive hypertrophy fibrosis....
Abstract Objective To describe the temporal trend of number new congenital heart disease (CHD) cases among newborns in Jinhua from 2019 to 2020 and explored an appropriate model fit forecast tendency CHD. Methods Data on CHD was collected a health information system. We counted with weekly separately used additive Holt-Winters ES method ARIMA predict for Jinhua. By comparing mean square error, rooted error absolute percentage each approach, we evaluated effects different approaches...