A5043531234- Psoriasis: Treatment and Pathogenesis
- Dermatology and Skin Diseases
- Cytokine Signaling Pathways and Interactions
- Acne and Rosacea Treatments and Effects
- Autoimmune Bullous Skin Diseases
- Drug-Induced Adverse Reactions
- Mast cells and histamine
- Allergic Rhinitis and Sensitization
- Urticaria and Related Conditions
- Asthma and respiratory diseases
- Inflammatory mediators and NSAID effects
- Facial Rejuvenation and Surgery Techniques
- Nonmelanoma Skin Cancer Studies
- Pharmacovigilance and Adverse Drug Reactions
- Biosimilars and Bioanalytical Methods
- Dermatologic Treatments and Research
- Wnt/β-catenin signaling in development and cancer
- Contact Dermatitis and Allergies
- Reconstructive Facial Surgery Techniques
- Monoclonal and Polyclonal Antibodies Research
- Phosphodiesterase function and regulation
- HER2/EGFR in Cancer Research
- Infectious Diseases and Mycology
- Herpesvirus Infections and Treatments
- Autoimmune and Inflammatory Disorders Research
Zhejiang University
2012-2025
Second Affiliated Hospital of Zhejiang University
2006-2025
Fourth Affiliated Hospital of Anhui Medical University
2024
Anhui Medical University
2024
Abstract Background Xeligekimab (GR1501) is a fully human monoclonal antibody that selectively neutralizes interleukin (IL)-17A and has shown potential efficacy in treating moderate-to-severe psoriasis preliminary trials. Objectives To evaluate the safety of xeligekimab Chinese patients with psoriasis. Methods A total 420 were randomized to 200 mg every 2 weeks (n = 281) or placebo 139) for first 12 weeks, followed by an extension treatment schedule 4 further 40 weeks. Efficacy was assessed...
Atopic dermatitis (AD) is a chronic inflammatory skin disease. 611, humanized monoclonal antibody, selectively targets the interleukin (IL)-4 receptor alpha, thereby inhibiting signaling of both and IL-13. This phase 2 study aimed to evaluate efficacy safety 611 in Chinese adults with moderate-to-severe AD. randomized, double-blind, placebo-controlled was conducted between October 2022 September 2023. Eligible patients AD were randomly assigned 1:1:1 ratio receive at dose either 300 mg...
Abstract Background: Topical finasteride is a novel treatment for men with an androgenetic alopecia (AGA). This study aimed to evaluate the efficacy and safety of topical spray solution in Chinese AGA. Methods: randomized, double-blind, placebo-controlled, phase III trial enrolled 270 individuals AGA from 16 sites across China between December 2021 March 2023. The participants were randomized at ratio 2:1 receive either or placebo once daily 24 weeks. primary endpoint was change baseline...
Allergen-specific immunotherapy is widely used for allergic rhinitis and asthma treatment worldwide. This study explored the efficacy safety of sublingual (SLIT) with extracts Dermatophagoides Farinae (D. farinae Drops) on house dust mites (HDM)-induced atopic dermatitis (AD). 239 patients HDM-induced AD were recruited exposure to a multi-centre, randomized, double-blind, placebo-controlled clinical trials 36 weeks, which randomly divided into placebo D. Drops groups (high-dose, medium-dose...
Anti-tumor necrosis factor alpha (TNF- α) therapy has made a significant impact on treating psoriasis. Despite these agents being designed to block TNF- α activity, their mechanism of action in the remission psoriasis is still not fully understood at molecular level. To better understand mechanisms Anti-TNF- therapy, we analysed global gene expression profile (using mRNA microarray) peripheral blood mononuclear cells (PBMCs) that were collected from 6 patients before and 12 weeks after...
1Department of Dermatology, Second Affiliated Hospital, School Medicine, Zhejiang University, Hangzhou, China Address Correspondence and reprint requests to: Xiao-Hong Mao, MD, Department Jiefang Road 88#, Hangzhou 310009, China, or e-mail: [email protected] Grant sponsor: Medical Science Research Fundation Province; Number: 2009B076. The authors have indicated no significant interest with commercial supporters.
Abstract Axillary osmidrosis (AO) is a common condition characterized by an offensive odor arising from apocrine gland secretions in the axillae that socially and psychologically impairs affected individuals. The exact aetiology of AO still not fully understood, but genetic factors have been suggested to play important role. Recently, single nucleotide polymorphism (SNP) rs17822931 ABCC11 gene located on human chromosome 16q12.1 has shown be associated with AO. In this study, we genotyped...
Abstract Background Excision of upper eyelid skin cancer often leads to moderate large defect. Numerous procedures are available reconstruct such defects, and the reconstructive path chosen should be individualized for each patient. The aim reconstruction is a movable eyelid, perfect corneal protection, good aesthetic quality, acceptable sequelae at donor site. purpose this paper was present unique one‐stage procedure. Methods A 79‐year‐old male suffered from carcinoma on his left medial...
Background: TNF-α inhibitors are effective biological agents for treating psoriasis, but the treatment responses differ across patients. This study aimed to identify genetic biomarkers of anti-TNF-α response in Chinese psoriasis patients using a genome-wide association approach. Methods: We recruited two independent cohorts administered etanercept biosimilar (with or without methotrexate). identified 61 and 87 good responders (PASI improvement ≥75%), 19 10 poor <50%) after 24 weeks...
Drug eruption is a major problem of adverse drug reactions and may present as variform clinical manifestations. Toxic epidermal necrolysis (TEN) acute generalized exanthematous pustulosis (AGEP) are relatively rare severe eruptions. It has rarely been reported that AGEP overlaps or mimics TEN, while no purulent bullous reported. The study reports case an adult female patient with the manifestations bulla caused by ingestion. discussed to reveal whether new pattern identified.
BACKGROUND:Ustekinumab, a human-derived monoclonal antibody that targets the p40 subunit of interleukin (IL)-12 and IL-23, has excellent clinical efficacy safety in treating psoriasis, with long half-life. However, no reports have described use human skin/serum samples to elucidate its molecular mechanisms. MATERIAL AND METHODS:Twenty-four psoriasis patients were enrolled our double-blind study randomly divided into placebo ustekinumab-administered groups. Dynamic changes area-severity index...
The dosages of valaciclovir used for herpes zoster treatment recommended by Chinese pharmaceutical companies can differ considerably from those reported in the literature. This randomized clinical study compares efficacy and safety different oral doses adults.A total 214 patients with were enrolled into two groups according to age: 98 18-44-year group (younger patients) 116 45-74-year (middle-aged elderly patients). Patients age then prescribed valaciclovir. high-dose was administered 900 mg...
Objective To investigate the state of insulin resistance and its relationship to serum resistin levels disease activity in patients with systemic lupus erythematosus (SLE), as well effects corticosteroid therapy on RI levels. Methods Forty SLE 31 age-and sex-matched normal human controls were enrolled into this study informed consent. A total 56 blood samples obtained from 21 cases active 35 inactive together controls. Fasting glucose (FBG) fasting measured. Homeostatic model assessment...
Objective. This phase I study aimed to systematically assess the safety, local tolerability, pharmacokinetics, and preliminary efficacy of topical icotinib hydrochloride cream in patients with mild moderate plaque psoriasis. Materials Methods. Eligible Chinese adult psoriasis were assigned or vehicle group. Icotinib increasing concentrations (0.5%, 1.0%, 2.0%, 4.0%) administered by fingertip unit method skin lesions twice a day for 4 weeks. Safety assessments included incidence severity...
The efficacy and safety of calcipotriol plus betamethasone dipropionate gel for the treatment scalp psoriasis has previously been demonstrated in a four-week trial Chinese population. To evaluate long-term two-compound adult patients with psoriasis. A multicentre, prospective, randomized, active-controlled was established which subjects were randomized (at ratio 4:1) to receive either once daily or solution twice 28 weeks. Incidence adverse drug reactions (ADRs) any type events (AEs) concern...
Psoriasis is a T-cell mediated disease that involves IL-23/Th17 and IL-12/Th1 axes. Ustekinumab, fully human monoclonal antibody targeting the p40 subunit of both IL-12 IL-23, has proven to be efficient safe for treating patients with psoriasis. Yet, there have been no reports skin/blood samples would elucidate molecular mechanisms by which ustekinumab calms psoriasis skin lesions. To investigate efficacy pathway (RORC, t-BOX GATA) in A total 30 were randomized into placebo group treatment...
Psoriasis is a chronic inflammatory disease that considered by network of immunocytes and cytokines. Among all, Th17 cells-derived IL-17 critical driving factor in the pathogenesis psoriasis. Recently, disruption extracellular matrix was found to be related psoriasis progression. In present study, we aimed investigate role heparanase (HPSE) crosstalk with signalling pathway. Skin tissues from non-affected areas psoriatic lesion before after 12 weeks monoclonal antibody treatment 30 patients...