A5013205197- Skin and Cellular Biology Research
- Monoclonal and Polyclonal Antibodies Research
- Hair Growth and Disorders
- Glycosylation and Glycoproteins Research
- Extracellular vesicles in disease
- S100 Proteins and Annexins
- Mesenchymal stem cell research
- Wnt/β-catenin signaling in development and cancer
- Acne and Rosacea Treatments and Effects
- melanin and skin pigmentation
- Cancer-related molecular mechanisms research
- Nonmelanoma Skin Cancer Studies
- Dermatologic Treatments and Research
- Bacteriophages and microbial interactions
- Autoimmune Bullous Skin Diseases
- Toxin Mechanisms and Immunotoxins
- Proteoglycans and glycosaminoglycans research
- Cutaneous Melanoma Detection and Management
- Dermatology and Skin Diseases
- Advancements in Transdermal Drug Delivery
- Antimicrobial Peptides and Activities
- Infectious Diseases and Mycology
- Optical Coherence Tomography Applications
- Bartonella species infections research
- RNA regulation and disease
Wuxi People's Hospital
2023-2025
Xian Yang Central Hospital
2025
Wuxi No.2 People's Hospital
2014-2024
Nanjing Medical University
2014-2023
Jiangnan University
2023
Second Affiliated Hospital of Nanjing Medical University
2020-2022
Shanxi Medical University
2015-2020
Second Hospital of Shanxi Medical University
2015-2020
Army Medical University
2007-2009
Southwest Hospital
2009
Abstract Background Accumulating evidence shows that mesenchymal stem cell-derived extracellular vesicles (EVs) hold great promise to promote hair growth. However, large-scale production of EVs is still a challenge. Recently, exosome-mimetic nanovesicles (NV) prepared by extruding cells have emerged as an alternative strategy for clinical-scale production. Here, ReNcell VM (ReN) cells, neural progenitor cell line was serially extruded produce NV. Results ReN-NV were found dermal papilla...
Abstract Background: Topical finasteride is a novel treatment for men with an androgenetic alopecia (AGA). This study aimed to evaluate the efficacy and safety of topical spray solution in Chinese AGA. Methods: randomized, double-blind, placebo-controlled, phase III trial enrolled 270 individuals AGA from 16 sites across China between December 2021 March 2023. The participants were randomized at ratio 2:1 receive either or placebo once daily 24 weeks. primary endpoint was change baseline...
Abstract Background Acral lentiginous melanoma (ALM) is a highly malignant and invasive type of with unique locations onset. Its incidence increasing early diagnosis challenging. Reflectance confocal microscopy (RCM) non‐invasive technique that provides an accurate image tissue pathology. There are few reports on the use RCM for assessment ALM. Materials methods In this retrospective study, data from 31 patients clinical ALM were collected. features compared histopathological findings to...
Lichen sclerosus et atrophicus (LSA) is a chronic inflammatory disease. The clinical presentation clustered distribution of porcelain white spots that can be fused together. Early diagnosis LSA difficult, especially in the vulva, where it difficult to distinguish from vitiligo. Traditional diagnostic methods mainly rely on histopathology. In this study, we used reflectance confocal microscopy (RCM) study characteristics and We investigated features 40 cases histopathologically proven genital...
The dermal papilla is a major component of hair, which signals the follicular epithelial cells to prolong hair growth process. Human Annexin A2 was preliminarily identified by two-dimensional gel electrophoresis (2-DE), MALDI-TOF-MS and database searching. aim present study explore role in aggregative papillae (DPC). Reverse transcription-polymerase chain reaction (RT-PCR) Western blot were adopted detect expression A2. And siRNA technique used suppress Construction over-expression vector...
Background： Patients with multifocal superficial basal cell carcinomas (sBCC) require a non-invasive treatment and follow-up technique. Imiquimod 5% cream is new therapy for BCC. Reflectance confocal microscopy (RCM) non-invasive, real-time imaging technique.
 Methods：The efficacy of imiquimod the sBCC was evaluated, as well potential RCM assessing therapeutic effects. We reported four patients 34 lesions were treated cream. performed in baseline at 12 weeks, 24 weeks 52 after starting...
Objective To evaluate the performance of endoscopy combined with ultrasonic knife in treatment bromidrosis.Methods Eight patients bilateral bromidrosis were included this study.A small incision was made outside surgical region,and apocrine sweat glands axillary region endoscopically removed from all by under general anesthesia.The efficacy evaluated six months after operation.Results Efficacy evaluation revealed that seven rated as grade 0,and one 1 treatment.Skin exfoliation noted during...
Objective To analyze the expression characteristics of annexin A2 in dermal papilla cells (DPCs) with aggregative behavior. Methods Reverse transcriptase-polymerase chain reaction (RT-PCR) and Western blot were performed to measure mRNA protein expressions respectively DPCs or without behavior. Results The level was significantly higher behavior than those (0.50 ± 0.15 vs. 0.35 0.19, t= 8.26, P< 0.05). showed that had two isoforms, including one isoform a relative molecular mass...
Objective To study the expression ot secreted proteins in aggregated dermal papilla cells (DPCs).Methods DPCs were isolated from human scalp tissue and subjected to primary culture subculture.Aggregated non-aggregated served as subject of this study.Secreted prepared these two-dimensional polyacrylamide gel electrophoresis.Differentially expressed screened by PDQuest image analysis software.Protein spots digested identified matrix-assisted laser desorption/ionization time-of-flight...
摘要： 例1 患者女，44岁，因多发性脱发斑9个月、头发全部脱落2个月就诊。2020年5月患者无明显诱因下头顶、枕部出现多发性脱发斑，2020年7月21日至2021年2月24日于我科先后接受肌注复方倍他米松、口服复方甘草酸苷片、外用糖皮质激素药膏（具体不详）治疗，未见好转，头发渐全部脱落……
Objective To detect the expression and function of cysteinyl leukotriene receptors (CysLTRs)in keratinocytes.Methods Human keratinocytes were isolated from tissue foreskin by digestion with dispase Ⅱ trypsin,and subjected to primary culture.By using confocal laser scanning microscopy reverse transcriptase PCR,the localization CysLTRs studied in kemtinocytes.respectively.Some primarily cultured pretreated D4 (30 nmoi/L),MK571(300 nmol/L),and BAYu9773 for 5 minutes followed detection...