A5037736874- Dermatologic Treatments and Research
- Systemic Sclerosis and Related Diseases
- Autoimmune Bullous Skin Diseases
- Skin Diseases and Diabetes
- Eosinophilic Disorders and Syndromes
- Inflammatory Myopathies and Dermatomyositis
- Hair Growth and Disorders
- Dermatology and Skin Diseases
- Psoriasis: Treatment and Pathogenesis
- Healthcare Systems and Reforms
- Economic and Financial Impacts of Cancer
- Global Health Care Issues
Chinese PLA General Hospital
2020
Liaoning Cancer Hospital & Institute
2018
Fudan University
2013-2014
Zhongshan Hospital
2014
Abstract Introduction Although immune dysfunction plays a role in the pathogenesis of systemic sclerosis (SSc), involvement T helper 17 (Th17) and regulatory (Treg) cells remains unclear. We aimed to investigate presence Th17 Treg SSc patients collagen production fibroblasts. Methods analyzed inflammatory cell profiles skin 13 by immunohistochemistry, percentage peripheral blood mononuclear (PBMCs) 45 24 healthy controls flow cytometry, gene expression PBMCs real-time reverse...
Recent reports have demonstrated that endothelial cells are involved in vascular inflammatory injury systemic sclerosis (SSc) and interleukin-17A (IL-17A) plays a crucial role the pathogenesis of SSC. However, little is known about effects IL-17A on cell inflammation The aim our study was to investigate inflammation. Here, we showed mRNA protein levels were augmented peripheral blood more IL-17+ lymphocytes infiltrated perivascular areas skin SSC patients. patient serum induced chemokine...
Dermal vascular smooth muscle cells (DVSMCs) are important for wall fibrosis in microangiopathy of systemic sclerosis (SSc). T helper 17 cell-associated cytokines, particularly interleukin-17A (IL-17A), have been demonstrated to play a role the pathogenesis SSc. However, effect IL-17A on DVSMCs SSc has not established. In present study, we investigated patient-derived DVSMCs.DVSMCs from patients with and healthy subjects were incubated using or serum derived Subsequently, proliferation,...
This study aimed to explore the function of IFN-γ+ IL-17+ Th17 cells on fibrosis in systemic scleroderma (SSc). Blood and skin samples were collected from 20 SSc cases 10 healthy individuals. The percentage was detected using flow cytometry. vitro induction performed adopting PHA rIL-12. Gene expression via quantitative real-time polymerase chain reaction (qRT-PCR), whereas western blot analysis adopted for protein analysis. distribution significantly increased positively correlated with...
This study aims to understand the medical expenditure for liver cancer during 2002-2011 in urban areas of China.This is a retrospective study. Based on stratified cluster sampling method, survey collected basic personal information from related records. Two-tailed independent sample t-test, variance analysis, and Student-Newman-Keuls Tests were used cost analysis corresponding data types.A total 12,342 patients included analysis. Overall average per case diagnosis treatment China has...
Background and Objectives Alopecia areata (AA) is an autoimmune disease characterized by T cell‐mediated attack on the hair follicle. Although there are a wide range of therapies, majority them not satisfactory due to side effects or limited efficacy. In this study, we sought evaluate efficacy, influence factors, safety 308‐nm excimer lamp with minoxidil in treatment AA. Study Design/Materials Methods This was prospective, single‐blinded, self‐control using for One selected alopecia lesion...
Abstract Background Recent studies have shown that Ro-52 antibody is associated with interstitial lung disease(ILD) in children dermatomyositis(DM) and the degree of disease severity. Moreover, we found 50% or more cases adult patients DM tested positive for Ro-52. Here, analyzed correlation between ILD inpatients DM. Objective To explore Methods A total 153 were collected, who met classification criteria idiopathic inflammatory myositis. Immunoblotting was used to detect 16...