A5101983875- Osteoarthritis Treatment and Mechanisms
- Systemic Sclerosis and Related Diseases
- Psoriasis: Treatment and Pathogenesis
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Spine and Intervertebral Disc Pathology
- Cancer-related molecular mechanisms research
- Medical Imaging and Analysis
- Toxoplasma gondii Research Studies
- Bone Metabolism and Diseases
- Dermatologic Treatments and Research
- Allergic Rhinitis and Sensitization
- Orthopaedic implants and arthroplasty
- Rheumatoid Arthritis Research and Therapies
- Antiplatelet Therapy and Cardiovascular Diseases
- Autoimmune Bullous Skin Diseases
- Hippo pathway signaling and YAP/TAZ
- Dermatology and Skin Diseases
- Autophagy in Disease and Therapy
- Cardiac Imaging and Diagnostics
- RNA modifications and cancer
- Cervical and Thoracic Myelopathy
- Spondyloarthritis Studies and Treatments
- Bone health and treatments
- Retinoids in leukemia and cellular processes
- T-cell and B-cell Immunology
Third Xiangya Hospital
2014-2024
Central South University
2010-2024
Second Xiangya Hospital of Central South University
2024
Pulmonary Associates
2024
Chinese PLA General Hospital
2010-2020
The cartilage stem/progenitor cells (CSPC) play a critical role in maintaining homeostasis. However, the effects of phenotypic fluctuations CSPC on degeneration and pathogenesis OA is largely unknown. samples 3 non-OA 10 patients were collected. Human (hCSPC) derived from these isolated, identified, evaluated for cellular functions. Additionally, chondrocytes isolated. effect Yes-associated protein (YAP) expression hCSPC was investigated vitro. rat model established by Hulth's method....
This study aimed to explore the function of IFN-γ+ IL-17+ Th17 cells on fibrosis in systemic scleroderma (SSc). Blood and skin samples were collected from 20 SSc cases 10 healthy individuals. The percentage was detected using flow cytometry. vitro induction performed adopting PHA rIL-12. Gene expression via quantitative real-time polymerase chain reaction (qRT-PCR), whereas western blot analysis adopted for protein analysis. distribution significantly increased positively correlated with...
Abstract Osteoporosis is one of the most common metabolic bone diseases affecting millions people. We previously found that harmine prevents loss in ovariectomized mice via increasing preosteoclast platelet‐derived growth factor‐BB (PDGF‐BB) production and type H vessel formation. However, molecular mechanisms by which promotes PDGF‐BB generation are still unclear. In this study, we revealed inhibitor DNA binding‐2 (Id2) activator protein‐1 (AP‐1) were important factors implicated...
Abstract Background Guidelines on coronary intermediate lesions strongly recommend deferred revascularization after detecting a normal fractional flow reserve (FFR). Researches about triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) cardiovascular diseases has also been well conducted. However, the association of TG/HDL-C and long-term adverse clinical outcomes remains unknown for patients following FFR. Methods This study retrospectively included 374 artery disease (CAD) with...
Intervertebral disc degeneration (IDD) refers to the abnormal response of cell-mediated progressive structural failure. In order understand molecular mechanism maintenance and destruction intervertebral disc, new IDD treatment methods are developed. Here, we first analyzed key regulators through microRNAs microarrays. Then, level miR-31-5p was evaluated by qRT-PCR. The association between Stromal cell-derived factor 1 (SDF-1)/CXCR7 axis assessed 3′-untranslated region (UTR) cloning...
To investigate the role of miR-181a in promoting proliferation and metastasis osteosarcoma cells by targeting RASSF1A. The level 30 human tissues corresponding bone was detected real-time PCR, correlation between clinicopathological characteristics analyzed. Osteosarcoma MG-63 were transfected with chemically-synthesized mimics inhibitors, proliferation, migration invasion MTT Transwell assay. specific binding ability to RASSF1A 3'-UTR theoretically predicted dual luciferase reporter gene...
Abstract Intervertebral disc degeneration (IDD) refers to the abnormal response of cell-mediated progressive structural failure. In order understand molecular mechanism maintenance and destruction intervertebral disc, new IDD treatment methods are developed. Here, we first analyzed key regulators through miRNA microarrays. The cell structure morphology were discovered by Histological radiographic. Then, level miR-31-5p was disclosed qRT-PCR. association between SDF-1/CXCR7 axis...