A5029947113- Contact Dermatitis and Allergies
- Alzheimer's disease research and treatments
- Cytokine Signaling Pathways and Interactions
- Proteoglycans and glycosaminoglycans research
- Glycosylation and Glycoproteins Research
- Pharmacogenetics and Drug Metabolism
- Angiogenesis and VEGF in Cancer
- RNA regulation and disease
- Vascular Tumors and Angiosarcomas
- melanin and skin pigmentation
- Streptococcal Infections and Treatments
- Eicosanoids and Hypertension Pharmacology
- Oral and Maxillofacial Pathology
- Dialysis and Renal Disease Management
- Drug-Induced Adverse Reactions
- Cancer, Hypoxia, and Metabolism
- Peptidase Inhibition and Analysis
- Bone health and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Dermatology and Skin Diseases
- Ion Transport and Channel Regulation
- Drug Transport and Resistance Mechanisms
- Salivary Gland Tumors Diagnosis and Treatment
- Inflammatory Myopathies and Dermatomyositis
- Magnesium in Health and Disease
University of Calgary
2016-2022
National Center For Child Health and Development
2020-2022
Regeneron (United States)
2021
Fuji Heavy Industries Health Insurance Society Ota Memorial Hospital
2016
Mukogawa Women's University
2013-2015
Nagoya University
2015
Kumamoto University
2009-2014
Kawasaki Medical School
2011-2012
Kindai University
2006-2007
Osaka City University
2006
The biological effect of interleukin-6 (IL-6) signaling in oral squamous cell carcinoma (OSCC) and whether IL-6 receptor (IL-6R)-mediated can be a therapeutic target for OSCC are unclear. aim this study was to investigate the effects inhibition IL-6R-mediated on progression evaluate availability tocilizumab, humanized antihuman IL-6R antibody, as agent OSCC.We evaluated expression levels 58 tissues 4 lines by real-time quantitative reverse transcription-PCR and/or immunohistochemstry. We...
Background Dupilumab is an antibody against interleukin-4 receptor α, used in the treatment of atopic dermatitis (AD). Objectives To evaluate efficacy and safety dupilumab adult Chinese patients with moderate-to-severe AD. Methods In this randomized, double-blind, placebo-controlled, parallel-group, phase III study, conducted between December 2018 February 2020, AD received (300 mg) or placebo once every 2 weeks for 16 weeks, were followed up 12 weeks. The primary endpoint was proportion...
Abstract Lymph node metastasis is associated with resistance to conventional therapy and poor survival of patients oral squamous cell carcinoma (OSCC). Although lymphangiogenesis well known be the occurrence lymph in various cancers, precise mechanisms OSCC are largely unknown. IL‐6, a potent pro‐inflammatory cytokine, has been shown play active roles including OSCC. This study aimed investigate involvement IL‐6 signalling lymphatic evaluate efficacy tocilizumab, humanized anti‐human...
The Cytochrome P450 is the major enzyme involved in drug metabolism. CYP enzymes are responsible for metabolism of most clinically used drugs. Individual variability activity one important factor that contributes to therapy failure. We have developed a new straightforward TaqMan PCR genotyping assay investigate prevalence common allelic variants polymorphic CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A5 Japanese population. Moreover, we focused on combination each genotype clinical treatment....
We have developed a new method for directly using unprocessed biological specimens as templates the TaqMan assay. DNA extraction and purification had been believed to be required assay, but our could avoid hindering fluorescence detection, even if were used directly. Saliva was needed put on water-soluble paper dried, hairs cut about 10 mm long. This reduce both time effort involved, also risk of contamination. It should prove very valuable genetic diagnoses in various fields.
Clinical applications of a chemotherapeutic agent, 5‐fluorouracil (5‐FU) in oral squamous cell carcinoma (OSCC) have been limited because drug resistance. This study aimed to identify novel mechanisms 5‐FU Here we found increased osteopontin (OPN) gene expression OSCC tissues with resistance 5‐FU‐based chemoradiotherapy. OPN overexpression cells led and abrogated the prosurvival effect mouse xenograft model. OPN‐induced required integrin α v β 3 . Targeting reversed 5‐FU‐resistant clone...
Neutrophil gelatinase-associated lipocalin (NGAL) is a member of the superfamily. Although its overexpression in various cancers has been reported, little known about expression and clinical significance oral squamous cell carcinoma (OSCC). This study aimed to elucidate NGAL OSCC.We investigated immunohistochemically tumour cells stromal 96 OSCC tissues. correlated significantly with histological differentiation, as shown by specific distribution horn pearl-forming keratinized cells, but not...
Journal Article Necrotizing fasciitis in a patient with rheumatoid arthritis treated tocilizumab Get access Akiko Yoshida, Yoshida Department of Rheumatology, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama 701-0192, Japan Search for other works by this author on: Oxford Academic Google Scholar Tomoko Ota, Ota Dermatology, Shunsuke Sasaoka, Sasaoka Hironori Matsuura, Matsuura Wataru Fujimoto, Fujimoto Yoshitaka Morita Correspondence to: Morita, e-mail: morita@med.kawasaki-m.ac.jp...
The purpose of this study was to determine the localization aquaporin-1 (AQP1) water channel in peritoneal tissues and effect hyperosmolality on expression function AQP1.Immunohistochemical AQP1 identified rat tissues. Cultured mesothelial cells (RPMCs) were exposed by adding 4% glucose culture medium. After 1 hour, 4 hours, 24 48 semiquantitative immunoblot immunocytochemistry. Osmotic permeability measured using a light-scattering method.Immunohistochemistry showed presence cells, venular...
Objectives: The purpose of this study was to identify associations between ALDH2 and ADH1B genotypes ethanol-induced cutaneous erythema assess the accuracy an ethanol patch test in young Japanese women. Methods: subjects were 942 female university students. They given examined for both immediately after removing 10 minutes patch. A saliva sample used determine genotype each subject by realtime PCR. Results: sensitivity specificity as marker presence inactive 69.6% 87.7%, respectively, 85.2%...
Background: Toxic amyloid-β (Aβ) peptides aggregate into higher molecular weight assemblies and accumulate not only in the extracellular space, but also walls of blood vessels brain, increasing their permeability, promoting immune cell migration activation. Given prominent role system, phagocytic cells may contact pathological brain materials. Objective: To develop a novel method for early Alzheimer’s disease (AD) detection, we used leukocytes, that could act as “sentinels” after trafficking...