A5011672858- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- IL-33, ST2, and ILC Pathways
- Metabolism, Diabetes, and Cancer
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Fibroblast Growth Factor Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Adipokines, Inflammation, and Metabolic Diseases
- Eosinophilic Esophagitis
- Colorectal Cancer Treatments and Studies
- Peroxisome Proliferator-Activated Receptors
- Genetic Syndromes and Imprinting
- Pancreatic function and diabetes
- Nutrition, Genetics, and Disease
- Epigenetics and DNA Methylation
- Genetic factors in colorectal cancer
- BRCA gene mutations in cancer
Brigham and Women's Hospital
2016-2023
Trinity College Dublin
2021-2023
Harvard University
2016-2018
Boston University
1994
Institute of Experimental Cardiology
1994
Abstract NK cells and CD8 T use cytotoxic molecules to kill virally infected tumor cell targets. While perforin granzyme B (GzmB) are the most commonly studied lytic molecules, less is known about K (GzmK). However, this has been recently associated with improved prognosis in solid tumors. In study, we show that, humans, GzmK predominantly expressed by innate-like lymphocytes, as well a newly identified population of GzmK+CD8+ non– mucosal-associated invariant characteristics. We found that...
M2 macrophages, innate lymphoid type 2 cells (ILC2s), eosinophils, Tregs, and invariant NK T (iNKT cells) all help to control adipose tissue inflammation, while M1 TNF, other inflammatory cytokines drive inflammation insulin resistance in obesity. Stromal regulate leukocyte responses lymph nodes, but the role of stromal is unknown. PDGFRα+ are major producers IL-33 tissue. Here, we show that mesenchymal cadherin-11 modulates fibroblast function. Cadherin-11-deficient mice displayed increased...
The development of an extralymphatic T-lymphocyte focus inflammation requires chemoattractant-induced cell migration and growth factor-induced proliferation. In a previous study, we identified novel 13- to 15-kDa T-lymphocyte-specific chemotactic cytokine, endothelial cell-derived lymphocyte chemoattractant activity (ED-LCA), secreted by serotonin-stimulated human aortic cells. Based on its physicochemical functional characteristics antibody inhibition studies, ED-LCA is distinct from...
Abstract Introduction Selection criteria for immunotherapy with checkpoint blockade in colorectal cancer are currently based on mismatch repair status. However, intra-tumoral T cell response varies among patients the same MMR Inhibitory expression tumour-infiltrating lymphocytes microsatellite stable and unstable CRC is unknown. Method Flow cytometric analysis single-cell RNA sequencing, using 10x genomic platform, were performed ex vivo tumour uninvolved colonic tissue samples from...