A5115603098- Systemic Sclerosis and Related Diseases
- Dermatologic Treatments and Research
- Laser Applications in Dentistry and Medicine
- Acne and Rosacea Treatments and Effects
- Epigenetics and DNA Methylation
- melanin and skin pigmentation
- Healthcare and Venom Research
- Biochemical Analysis and Sensing Techniques
- Phytochemistry and Biological Activities
- Nanoparticles: synthesis and applications
- MicroRNA in disease regulation
- Skin Protection and Aging
- NF-κB Signaling Pathways
- Graphene and Nanomaterials Applications
- Advancements in Transdermal Drug Delivery
- interferon and immune responses
- Mast cells and histamine
- Histone Deacetylase Inhibitors Research
- Wnt/β-catenin signaling in development and cancer
- Photodynamic Therapy Research Studies
- Phytochemicals and Antioxidant Activities
- Oral Health Pathology and Treatment
- Microplastics and Plastic Pollution
- Cytokine Signaling Pathways and Interactions
- Extracellular vesicles in disease
Chinese PLA General Hospital
2024
The Military General Hospital of Beijing PLA
2005-2022
Silver nanoparticles are receiving increasing attention in biomedical applications. This study aims at evaluating the antifungal properties of silver against pathogenic fungus Trichosporon asahii.The growth T. asahii on potato dextrose agar medium containing different concentrations was examined and effect evaluated using minimum inhibitory concentration. Scanning transmission electron microscopy were also used to investigate asahii.Silver had a significant asahii. The concentration 0.5...
Cutaneous warts caused by human papillomavirus are benign proliferative lesions that occur at any ages in lives. Updated, comprehensive and systematic evidence-based guidelines to guide clinical practice urgently needed.We collaborated with multidisciplinary experts formulate this guideline based on evidences of already published literature, focusing 13 questions elected a panel experts. We adopted Grading Recommendations Assessment, Development Evaluation (GRADE) system form classification...
BACKGROUND:MicroRNAs (miRNA) dysregulation has been considered to be significantly related the occurrence and development of cancers. Several studies had proved that DNA methylation is an important cause abnormal expression miRNAs. The purpose this study was investigate status miR-148a its effects on metastasis prognosis skin cancer, as well interaction with TGIF2 gene. MATERIAL AND METHODS:According qRT-PCR analysis, down-regulated in tumor tissues compared adjacent healthy controls...
Scleroderma (systemic sclerosis) is a connective tissue disease that affects various organ systems; the treatment of scleroderma still difficult and remains challenge to clinician. Recently, kinase inhibitors have shown great potential against fibrotic diseases and, specifically, transforming growth factor-β receptor (TGF-βR) was found as new promising target for therapy. In current study, we propose large pool existing could be exploited inhibiting TGF-βR suppress scleroderma. this respect,...
Melanogenesis is a physiological process that results in the synthesis of melanin pigments, which serve crucial function hyperpigmentation. The aim present study was to determine effects angiotensin II (Ang II) on melanogenesis and elucidate molecular events Ang II‑induced melanogenesis. Experiments were performed human melanocytes pigmenting effect underlying mechanisms. elements involved melanogenesis, including content, tyrosinase (TYR) activity, microphthalmia‑associated transcription...
The aim of the current study was to observe effects suppressor cytokine signaling 1 (SOCS1) silencing in human melanoma cells on cell biological behavior and interferon‑γ (IFN‑γ) sensitivity, investigate use SOCS1 as a therapeutic target treatment melanoma. Western blot analysis reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) were used verify that interference effectively silenced expression Mel526 line. For IFN‑γ stimulation, western changes levels signal transduction...
Angiotensin II (AngII) is a hormone with long‑established cardiovascular actions. Previous studies have revealed an additional role for AngII in the regulation of cutaneous wound healing. To evaluate association between and abnormal pigmentation healing, present study used human melanocytes to investigate effects on melanogenesis, elucidate possible underlying mechanisms. Primary culture were treated either alone or combination type 1 (AT1) receptor antagonist, losartan (LOS). The melanin...
Inhibition of histone deacetylase (HDAC) activity by HDAC inhibitors (HDACis) results in cancer cell growth inhibition, and HDACis have been revealed as potential anti-skin agents. p21 is a cyclin-dependent kinase inhibitor an essential regulator inhibition. Recently, we reported that activating transcription factor 3 (ATF3) could significantly promote skin growth. This study explored the relationship between ATF3 HDACi-induced inhibition epidermoid carcinoma cells. We found trichostatin A...
Immune responses are somewhat suppressed in immune privileged sites, including the testes, which provide a preexisting opportunity to prolong allograft survival. Previous studies have shown that intratesticular islet allografts enjoy extended survival even without any immunosuppression. However, it is unknown if testicular privilege can be exploited of solid allograft, skin, because impractical implant tissue human testes.To immunize recipient mice, splenocytes from BALB/c mice were injected...
Silver nanomaterials have been widely proven to antifungal effects against
Objective To screen, analyze and predict microRNAs (miRNAs) related to systemic scle-roderma (SSc). Methods Differentially expressed miRNAs between tissue samples from 3 patients with SSc normal human controls were screened a gene chip including 924 miRNAs. Target genes regulated by differentially searched bioinformatics method. Finally, predicted. Results There 24 of controls, 9 up-regulated 15 down-regulated Literature review disclosed that was associated target hsa-miR-206, has-let-7g,...
Objective To observe morphological characteristics and activity distribution of T. asahii biofilm. Methods The biofilm were observed under an inverted microscope scanning electron microscope, was measured quantitatively analyzed by 2,3-bis (2-methoxy-4-nitro-5-sulfophenyl)-5-[(phenylamino) carbonyl]-2H-tetrazo-lium hydroxide (XTT) assay viable count, respectively. Spatial dead/vital cells, thickness at different layers assessed a confocal laser (CLSM) following double staining with FDA/PI....
Objective To determine the effect of interferon-gamma (IFN-γ) on phagocytosis and killing activity a murine macrophage cell line RAW264.7 against T.asahii,and to estimate possibility treating T.asahii infection with IFN-γγ.Methods was cultured or without presence different concentrations (10,100,1000 U/ml) IFN-γfor 18 hours followed by incubation cells for durations.After additional culture 45 minutes,the number phagocytosed counted under an inverted microscope,and rate calculated.The colony...