A5085070532- Plant Disease Resistance and Genetics
- Circular RNAs in diseases
- Genetic diversity and population structure
- Identification and Quantification in Food
- Wound Healing and Treatments
- MicroRNA in disease regulation
- RNA modifications and cancer
- Extracellular vesicles in disease
- Fish Biology and Ecology Studies
- Nail Diseases and Treatments
- Acne and Rosacea Treatments and Effects
- Reproductive biology and impacts on aquatic species
- Mycobacterium research and diagnosis
- Fungal Infections and Studies
- Mesenchymal stem cell research
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Soil erosion and sediment transport
- T-cell and B-cell Immunology
- Photodynamic Therapy Research Studies
- Oral Health Pathology and Treatment
- RNA Research and Splicing
- Environmental Changes in China
- Laser Applications in Dentistry and Medicine
- Plant and Fungal Interactions Research
- Nanoparticles: synthesis and applications
Southwest Hospital
2016-2025
Army Medical University
2016-2025
Sichuan Agricultural University
2013-2024
Northwest A&F University
2024
Chinese PLA General Hospital
2020-2023
Lanzhou Jiaotong University
2012
Introduction Full-thickness skin wound healing remains a serious undertaking for patients. While stem cell-derived exosomes have been proposed as potential therapeutic approach, the underlying mechanism of action has yet to be fully elucidated. The current study aimed investigate impact derived from human umbilical cord mesenchymal cells (hucMSC-Exosomes) on single-cell transcriptome neutrophils and macrophages in context healing. Methods Utilizing RNA sequencing, transcriptomic diversity...
Background: Previous case reports hint ultraviolet A1 (UVA1) phototherapy as a novel adjunct treatment for acute cutaneous inflammations and neuralgia of herpes zoster, but its clinical effectiveness safety in this condition are not yet proven by trials. Objectives: To determine the efficacy UVA1 an inflammation zoster. Methods: A total 60 patients with moderate-to-severe zoster were randomly divided into two parallel groups. Group I received regular UVA1, II alone. Time blister crusting...
Trichosporon asahii is an emerging opportunistic pathogen that causes potentially fatal disseminated trichosporonosis. The global prevalence of coronavirus disease 2019 (COVID-19) poses increasing fungal infection burden caused by T. asahii. Allicin the main biologically active component with broad-spectrum antimicrobial activity in garlic. In this study, we performed in-depth analysis antifungal characteristics allicin against based on physiological, cytological, and transcriptomic...
The potential of human umbilical cord mesenchymal stromal cell-derived extracellular vesicles (hucMSC-EVs) in wound healing is promising, yet a comprehensive understanding how fibroblasts and keratinocytes respond to this treatment remains limited. This study utilizes single-cell RNA sequencing (scRNA-seq) investigate the impact hucMSC-EVs on cutaneous microenvironment mice. Through rigorous analyses, we unveil emergence hucMSC-EV-induced hematopoietic MMP13+ fibroblasts. Notably, exhibit...
Chronic wounds refer to those that can't reconstruct anatomical and physical functional integrity, are usually associated with signs of microbial infection. Current therapies include debridement dressing change, local or systemic application antibiotics, medical care, which not ideal for the healing chronic wounds. To explore efficacy safety photodynamic therapy (ALA-PDT) treatment infectious ALA-PDT was used in ten patients persistent wound infections complications who did respond...
The gene SLC15A4 (solute carrier family 15 [oligopeptide transporter], member 4) has been reported as contributing to the pathogenesis of systemic lupus erythematosus (SLE). We performed a case-control replication study investigate further association between single-nucleotide polymorphisms (SNPs) in and SLE Han Chinese population.In patients healthy individuals (n = 355, 375, respectively), 18 SNPs were genotyped using matrix-assisted laser desorption/ionization time-of-flight mass...
Abstract Background The ricefield eel Monopterus albus undergoes a natural sex change from female to male during its life cycle, and previous studies have shown the potential mechanisms of this transition at transcriptional protein levels. However, changes in levels not been fully explored, especially intersexual stage. Results In present study, expression patterns gonadal tissues five different periods, ovary (OV), early stage gonad (IE), middle (IM), late (IL), testis (TE), were determined...
Abstract Background Invasive Trichosporon asahii ( T. ) infection frequently occurs with a high mortality in immunodeficient hosts, but the pathogenesis of remains elusive. Circular RNAs (circRNAs) are type endogenous noncoding RNA that participate various disease processes. However, mechanism circRNAs completely unknown. Methods sequencing (RNA-seq) was performed to analyze expression profiles circRNAs, microRNAs (miRNAs), and mRNAs THP-1 cells infected or uninfected samples. Some RNA-seq...
Rhesus macaques living in western Sichuan, China, have been separated into several isolated populations due to habitat fragmentation. Previous studies based on the neutral or nearly markers (mitochondrial DNA microsatellites) showed high levels of genetic diversity and moderate differentiation Sichuan rhesus macaques. Variation at major histocompatibility complex (MHC) loci is widely accepted as being maintained by balancing selection, even with a low level variability some species. However,...
Garrulax sannio (Passeriformes, Timaliidae) was the medium-sized bird, whose plumage color similar for both sexes. The complete sequence of mitochondrial DNA genome from G. used polymerase chain reaction method. (17 840 bp in length) contained 13 protein-coding genes, 2 rRNA (12S and 16S) 22 tRNA genes control regions (D-loop). base composition mitogenome A + T percentage 52.22%. It is slightly higher than G C 47.78% which with other vertebrates. Through constructed phylogenetic tree, we...
To the Editor: Psoriasis is a chronic immune-related inflammatory skin disease. The clinical severity of psoriasis varies greatly, and recurrence occurs frequently.[1] Many attempts have been made to identify biomarkers for psoriasis; however, there are currently no specific markers that can accurately monitor disease treatment efficacy. Circular RNAs (circRNAs) novel class endogenous noncoding highly stable resistant RNase R since they form covalently closed loops without 5′ caps 3′...
Background: Solar lentigines (SLs), serving as a prevalent characteristic of skin photoaging, present cutaneous aberrant pigmentation. However, the underlying pathogenesis remains unclear and there is dearth reliable diagnostic biomarkers. Objective: The aim this study was to identify biomarkers for SLs reveal its immunological features. Methods: In study, gene expression profiling datasets (GSE192564 GSE192565) were obtained from GEO database. GSE192564 used training group screening...
Silver nanomaterials have been widely proven to antifungal effects against
Abstract Background Trichosporon asahii is considered the most prominent species associated with invasive trichosporonosis, but little known about pathogenesis of T. infection in host. MicroRNAs (miRNAs) are a class noncoding endogenous small RNAs that play vital roles by manipulating immune responses against pathogenic microorganisms. Nevertheless, exact functions miRNAs still unknown. Objective To investigate interactions involved miRNA response THP‐1 macrophages following vitro exposure...