A5041869508- Advanced MRI Techniques and Applications
- NMR spectroscopy and applications
- Advanced Neuroimaging Techniques and Applications
- MRI in cancer diagnosis
- Advanced NMR Techniques and Applications
- Mass Spectrometry Techniques and Applications
- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Protein Structure and Dynamics
- Characterization and Applications of Magnetic Nanoparticles
- Metabolomics and Mass Spectrometry Studies
- Nanoparticle-Based Drug Delivery
- Lipid Membrane Structure and Behavior
- Monoclonal and Polyclonal Antibodies Research
- Glycosylation and Glycoproteins Research
- Hemoglobin structure and function
- Bone and Joint Diseases
- Carbohydrate Chemistry and Synthesis
- Chemical Synthesis and Analysis
- Lanthanide and Transition Metal Complexes
- Neurological Disease Mechanisms and Treatments
- Molecular spectroscopy and chirality
- Enzyme Structure and Function
- Neuropeptides and Animal Physiology
- Neonatal Health and Biochemistry
University of New Mexico
2014-2025
Imaging Center
2016-2020
Mind Research Network
2018
Radiology Associates of Albuquerque
2016
New Mexico Cancer Center
2011-2012
University of Minnesota
1977-2012
UNM Comprehensive Cancer Center
2011
New Mexico Resonance
2007
Lovelace Respiratory Research Institute
1996
Los Alamos National Laboratory
1986-1995
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDetermination of water diffusion coefficients in perfluorosulfonate ionomeric membranesThomas A. Zawodzinski Jr., Michal Neeman, Laurel O. Sillerud, and Shimshon GottesfeldCite this: J. Phys. Chem. 1991, 95, 15, 6040–6044Publication Date (Print):July 1, 1991Publication History Published online1 May 2002Published inissue 1 July 1991https://pubs.acs.org/doi/10.1021/j100168a060https://doi.org/10.1021/j100168a060research-articleACS PublicationsRequest...
Abstract The geometric average of two spin‐echo images obtained with opposite polarity diffusion gradients yields cross‐term‐free that can be directly compared for anisotropy. This approach is demonstrated here free water isotropic and anisotropic in the phloem system celery ( Apium graveolens). © 1991 Academic Press, Inc.
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructure and metabolism of mammalian liver glycogen monitored by carbon-13 nuclear magnetic resonanceLaurel O. Sillerud Robert G. ShulmanCite this: Biochemistry 1983, 22, 5, 1087–1094Publication Date (Print):March 1, 1983Publication History Published online1 May 2002Published inissue 1 March 1983https://pubs.acs.org/doi/10.1021/bi00274a015https://doi.org/10.1021/bi00274a015research-articleACS PublicationsRequest reuse permissionsArticle...
Natural abundance carbon-13 nuclear magnetic resonances (NMR) from human arm and rat tissues have been observed in vivo. These signals arise primarily triglycerides fatty tissue. Carbon-13 NMR was also used to follow, a living rat, the conversion of C-1-labeled glucose, which introduced into stomach, liver glycogen. The sensitivity resolution obtained shows that natural will be valuable study disorders fat metabolism, experiments with substrates labeled can carbohydrate metabolism
Abstract High‐quality, high‐resolution, proton‐decoupled natural‐abundance 13 C NMR spectra have been obtained in vitro at 100.6 MHz from unprocessed human pathology specimens of tumors and adjacent nonneoplastic control tissues lung, colon, prostate. In these preliminary studies, specific molecular parameters were identified the that distinguished neoplastic tissue a given organ all sites studied. The results congruent with data derived histochemical biochemical examinations previous...
In our program to develop non-invasive magnetic resonance imaging (MRI) methods for the diagnosis of Alzheimer's disease (AD), we have synthesized antibody-conjugated, superparamagnetic iron oxide nanoparticles (SPIONs) use as an in vivo agent fo
No AccessJournal of UrologyInvestigative urology1 Nov 2006Citrate Concentrations in Human Seminal Fluid and Expressed Prostatic Determined via 1H Nuclear Magnetic Resonance Spectroscopy Outperform Prostate Specific Antigen Cancer Detection Eric E. Kline, G. Treat, Tiffany A. Averna, Michael S. Davis, Anthony Y. Smith, Laurel O. Sillerud KlineEric Kline Department Surgery, University New Mexico School Medicine Research Treatment Center, Albuquerque, , TreatEric Treat AvernaTiffany Averna...
High sensitivity differential scanning calorimetry has been employed to study the thermotropic behavior, over range from 12-83”C, of dispersed mixtures 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) with bovine brain ganglioside GM1 high purity. No thermal phase transitions pure alone in excess water could be detected, even at concentrations 4 mg/ml? temperature these studies. The heat capacity curve for multilamellar dis- persions DPPC was as previously reported, a pretransition 32.7”C...
Abstract BACKGROUND Androgen deprivation therapy, one of the standard treatments for prostate cancer (PCa) induces apoptosis, as well autophagy in androgen‐responsive PCa cells. As can promote either cell survival or death, it is important to understand its role treatment. The objective this study was elucidate function lipid droplet (LD) homeostasis and androgen‐sensitive METHODS To produce androgen deprivation, charcoal filtered serum inhibitor casodex were used LNCaP LAPC4 Autophagy...
Traumatic brain injury (TBI) is a major public health issue, with recently increased awareness of the potential long‐term sequelae repetitive injury. Although TBI common, objective diagnostic tools sound neurobiological predictors outcome are lacking. Indeed, such could help to identify those at risk for more severe outcomes after and improve understanding biological underpinnings provide important mechanistic insights. We tested hypothesis that acute subacute pathological injury, including...
Alzheimer's disease (AD) is associated with a microglia-dependent neuroinflammatory response against plaques containing the fibrous protein amyloid-β (Aβ). Activation of microglia, which closely associate Aβ plaques, engenders release pro
Cerebral small vessel disease (SVD) contributes to approximately 50% of human dementias world-wide and pose a burden the health care system worldwide. Early endothelial/blood-brain barrier (BBB) dysfunction is an important contributor pathogenesis SVD. Sphingosine-1-phosphate (S1P), membrane-derived signaling sphingolipid, regulates BBB integrity by binding its receptor isoform 1 (S1PR1) on endothelial cells. We previously showed that activation S1PR1 using SEW2871, selective agonist,...
Antibody-conjugated iron oxide nanoparticles offer a specific and sensitive tool to enhance magnetic resonance (MR) images of both local metastatic cancer. Prostate-specific membrane antigen (PSMA) is predominantly expressed on the neovasculature solid tumors surface prostate cells, with enhanced expression following androgen deprivation therapy. Biotinylated anti-PSMA antibody was conjugated streptavidin-labeled used in MR imaging confocal laser scanning microscopic studies using LNCaP...
This article describes the natural-abundance Fourier-transform carbon-13 nuclear magnetic resonance spectrum, at 67.88 MHz, of aqueous micelles bovine brain ganglioside GM1 purity greater than 99%. Assignments are given for every carbon nucleus in molecule, on basis a comprehensive study relevant mono-, di-, tri-, and polysaccharides, including several containing sialic acid (5-acetamido-3, 5-dideoxy-D-glycero-D-galacto-nonulopyranosonic acid), phospho-, sphingo-, glycosphingolipids. These...
Results: SPMs were 45.4 ± 24.9 nm in diameter and composed of 160.7 22.9 µg/mL iron, 247.0 33.4 platinum, 702.6 206.0 paclitaxel. Drug release measurements showed that, at 37°C, half the paclitaxel was released 30.2 hours serum two times faster saline. Binding assays suggested that PSMA-targeted specifically bound to C4-2 human prostate cancer cells vitro into cells. In vitro, 2.2 1.6 more cytotoxic than 24 48 incubation, respectively. After 72 equally cytotoxic. had MRI transverse...
Abstract Tauopathies, including frontotemporal dementia (FTD) and Alzheimer’s disease (AD) are progressive neurodegenerative diseases clinically characterized by cognitive decline could be caused the aggregation of hyperphosphorylated pathological tau (pTau) as neurofibrillary tangles (NFTs) inside neurons. There is currently no FDA-approved treatment that cures, slows or prevents tauopathies. Current immunotherapy strategies targeting pTau have generated encouraging data but may pose...