A5089951086- Traumatic Brain Injury and Neurovascular Disturbances
- Oceanographic and Atmospheric Processes
- Cardiovascular and Diving-Related Complications
- Marine and fisheries research
- Medical Imaging Techniques and Applications
- Traumatic Brain Injury Research
- Neuroscience and Neuropharmacology Research
- Radiomics and Machine Learning in Medical Imaging
- Marine and coastal ecosystems
- Ocean Acidification Effects and Responses
- MRI in cancer diagnosis
- Nanoparticle-Based Drug Delivery
- Glioma Diagnosis and Treatment
- Oil Spill Detection and Mitigation
- Spinal Cord Injury Research
- Neonatal and fetal brain pathology
- Marine Biology and Ecology Research
- Neuroscience of respiration and sleep
- Underwater Vehicles and Communication Systems
- Cardiac Arrest and Resuscitation
- Cerebrospinal fluid and hydrocephalus
- Sleep and Wakefulness Research
- Alzheimer's disease research and treatments
- Neurotransmitter Receptor Influence on Behavior
- Testicular diseases and treatments
University of New Mexico
2017-2025
Uniformed Services University of the Health Sciences
2014-2018
Center for Neuroscience and Regenerative Medicine
2014-2018
HJF Medical Research International
2018
Athinoula A. Martinos Center for Biomedical Imaging
2013
Harvard University
2013
Massachusetts General Hospital
2013
National Institutes of Health
2008-2009
National Heart Lung and Blood Institute
2008-2009
Scottish Association For Marine Science
2008
Effective transvascular delivery of nanoparticle-based chemotherapeutics across the blood-brain tumor barrier malignant gliomas remains a challenge. This is due to our limited understanding nanoparticle properties in relation physiologic size pores within barrier. Polyamidoamine dendrimers are particularly small multigenerational nanoparticles with uniform sizes each generation. Dendrimer increase by only 1 2 nm successive Using functionalized polyamidoamine dendrimer generations through 8,...
The existence of large pores in the blood-tumor barrier (BTB) malignant solid tumor microvasculature makes more permeable to macromolecules than endothelial most normal tissue microvasculature. BTB tumors growing outside brain, peripheral tissues, is that similar inside brain. This has been previously attributed larger anatomic sizes within tumors. Since physiological state vivo a fibrous glycocalyx layer coats BTB, it possible effective physiologic pore size brain and similar. If this were...
Abstract INTRODUCTION Pathological accumulation of tau (pTau) contributes to various tauopathies, including Alzheimer's disease (AD), and correlates with cognitive decline. A rapid surge in tau‐targeted approaches via anti‐sense oligonucleotides, active/passive immunotherapies suggests that targeting p‐Tau is a viable strategy against tauopathies. METHOD We describe multi‐species validation our previously described Qß virus‐like particle (VLP)–based vaccine technology phosphorylated on...
Traumatic brain injury (TBI) results in learning and memory dysfunction. Cognitive deficits result from cellular metabolic dysfunction after injury, including decreased cerebral glucose uptake inflammation. This study assessed the ability of intranasal insulin to increase reduce lesion volume, improve function Adult male rats received a controlled cortical impact (CCI) followed by or saline treatment daily for 14 days. PET imaging [18F]-FDG was performed at baseline 48 h 10 days post-injury...
Abstract Tauopathies, including frontotemporal dementia (FTD) and Alzheimer’s disease (AD) are progressive neurodegenerative diseases clinically characterized by cognitive decline could be caused the aggregation of hyperphosphorylated pathological tau (pTau) as neurofibrillary tangles (NFTs) inside neurons. There is currently no FDA-approved treatment that cures, slows or prevents tauopathies. Current immunotherapy strategies targeting pTau have generated encouraging data but may pose...
Chronic pain often predicts the onset of psychological distress. Symptoms including anxiety and depression after chronification reportedly are caused by brain remodeling/recruitment limbic reward/aversion circuitries. Pain is primary precipitating factor that has opioid overprescribing continued overuse opioids leading to current epidemic. Yet experimental therapies fail in clinical trials. Better understanding underlying pathologies contributing needed address these chronic related issues....
Traumatic brain injury (TBI) continues to be a major cause of death and disability worldwide. This study assessed the effectiveness non-invasive vagus nerve stimulation (nVNS) in reducing lesion volume improving neurobehavioral performance rat model TBI. Animals were randomized into three experimental groups: (1) TBI with sham treatment (Control), (2) treated five lower doses (2-min) nVNS, (3) higher (2 × 2-min) nVNS. We used gammaCore nVNS device deliver stimulations. Magnetic resonance...
Repeated mild traumatic brain injury (rmTBI) results in worsened outcomes, compared with a single injury, but the mechanism of this phenomenon is unclear. We have previously shown that TBI rat lateral fluid percussion model globally depressed glucose uptake, peak depression at 24 h resolves by 16 days post-injury. The current study investigated outcomes repeat conducted various times during period uptake. Adult male rats were therefore subjected to rmTBI latency h, 5 days, or 15 between...
Non-invasive measurements of brain metabolism using 18F-fluorodeoxyglucose (FDG) with positron emission tomography (PET) may provide important information about injury severity following traumatic (TBI). There is growing interest in the potential combining functional PET imaging anatomical and magnetic resonance (MRI). This study aimed to investigate effectiveness clinically available FDG-PET T2 diffusion MR imaging, a particular focus on inflammation influence glial alterations after...
Although certain drugs of abuse are known to disrupt brain glucose metabolism (BGluM), the effects opiates on BGluM not well characterized. Moreover, preclinical positron emission tomography (PET) studies anesthetize animals during scan, which limits clinical applications. We investigated (i) isoflurane anesthesia and (ii) intravenous morphine self-administration (MSA) in rats. Jugular vein cannulated adult male Sprague-Dawley rats self-administered either saline (SSA) or (0.5...
In clinical breast cancer intervention, selection of the optimal treatment protocol based on predictive biomarkers remains an elusive goal. Here, we present a modeling tool to predict likelihood response neoadjuvant chemotherapy using patient-specific tumor vasculature biomarkers. A semiautomated analysis was implemented and performed 3990 histological images from 48 patients, with 10–208 analyzed for each patient. We applied histology-based mathematical model 30 resected primary tumors then...
Permeability and permselective properties of plaque membranes were measured, after culturing them in a constricted space between bacteriological grade filters support screens. By for different times with added sugar, membrane produced 20 – 1 range measured carbohydrate to protein ratio variable packing density (dry weight membrane). Resistances plaques diffusion acetate, sucrose, sorbitol found be proportional the dry weight. Extracellular polysaccharide (as indicated by extractable content)...