A5054382943- Barrier Structure and Function Studies
- Acute Ischemic Stroke Management
- Pregnancy and Medication Impact
- Neurological Disease Mechanisms and Treatments
- Neonatal and fetal brain pathology
- Neuroinflammation and Neurodegeneration Mechanisms
- Traumatic Brain Injury and Neurovascular Disturbances
- Advanced Neuroimaging Techniques and Applications
- Vagus Nerve Stimulation Research
- Traumatic Brain Injury Research
- Reproductive System and Pregnancy
- Pharmacological Effects and Toxicity Studies
- S100 Proteins and Annexins
- Neonatal Respiratory Health Research
- Biochemical Analysis and Sensing Techniques
- Organ and Tissue Transplantation Research
- Pregnancy and preeclampsia studies
- Cancer-related molecular mechanisms research
- Hepatitis B Virus Studies
- Alzheimer's disease research and treatments
- MicroRNA in disease regulation
- Renal Transplantation Outcomes and Treatments
- Heme Oxygenase-1 and Carbon Monoxide
- Immune cells in cancer
- Protease and Inhibitor Mechanisms
University of New Mexico
2016-2025
Temple University Health System
2024
Zigong First People's Hospital
2021-2023
Imaging Center
2015-2021
Shanxi Medical University
2009-2019
First Affiliated Hospital of Wenzhou Medical University
2008-2014
Wenzhou Medical University
2008-2014
NorthShore University HealthSystem
2009-2012
University of Chicago
2011
University of Illinois Chicago
2004-2010
Minocycline reduces reperfusion injury by inhibiting matrix metalloproteinases (MMPs) and microglia activity after cerebral ischemia. Prior studies of minocycline investigated short-term neuroprotective effects during subacute stage stroke; however, the late against early on neurovascular remodeling are less well studied. We have shown that spontaneous angiogenesis vessels in ischemic brain regions high blood–brain barrier (BBB) permeability due to lack major tight junction proteins (TJPs)...
A multifunctional microRNA, miR-155, has been recently recognized as an important modulator of numerous biological processes. In our previous <i>in vitro</i> studies, miR-155 was identified a potential regulator the endothelial morphogenesis. The present study demonstrates that vivo</i> inhibition supports cerebral vasculature after experimental stroke. Intravenous injections specific inhibitor were initiated at 48 h mouse distal middle artery occlusion (dMCAO). Microvasculature in...
In cerebral ischemia, matrix metalloproteinases (MMPs) have a dual role by acutely disrupting tight junction proteins (TJPs) in the blood-brain barrier (BBB) and chronically promoting angiogenesis. Since TJP remodeling of neurovascular unit (NVU) is important recovery early inhibition MMPs neuroprotective, we hypothesized that short-term MMP would reduce infarct size promote angiogenesis after ischemia. Adult spontaneously hypertensive rats had transient middle artery occlusion with...
BackgroundVagus nerve stimulation (VNS) significantly reduces infarct volume in rat models of cerebral ischemia, but the mechanism this protective effect remains open.HypothesisThis study tested hypothesis that non-invasive VNS (nVNS), during transient middle artery occlusion (MCAO), protects blood-brain barrier (BBB), leading to reduced size ischemic brain.MethodsSpontaneous hypertensive rats (SHRs) were subjected a 90 min MCAO. nVNS treated received 5 stimulations (duration: 2 min; every...
Traumatic brain injury (TBI) is a major public health issue, with recently increased awareness of the potential long‐term sequelae repetitive injury. Although TBI common, objective diagnostic tools sound neurobiological predictors outcome are lacking. Indeed, such could help to identify those at risk for more severe outcomes after and improve understanding biological underpinnings provide important mechanistic insights. We tested hypothesis that acute subacute pathological injury, including...
Abstract Tauopathies, including frontotemporal dementia (FTD) and Alzheimer’s disease (AD) are progressive neurodegenerative diseases clinically characterized by cognitive decline could be caused the aggregation of hyperphosphorylated pathological tau (pTau) as neurofibrillary tangles (NFTs) inside neurons. There is currently no FDA-approved treatment that cures, slows or prevents tauopathies. Current immunotherapy strategies targeting pTau have generated encouraging data but may pose...
OBJECTIVE Traumatic brain injury (TBI) is a leading cause of death and severe morbidity for otherwise healthy full-term infants around the world. Currently, primary treatment infant TBI supportive, as no targeted therapies exist to actively promote recovery. The developing brain, in particular, has unique response potential repair, both which vary with maturation. Targeted interventions objective measures therapeutic efficacy are needed this special population. authors hypothesized that MRI...
Cerebral ischemia has been clearly demonstrated after traumatic brain injury (TBI); however, neuroprotective therapies have not focused on improvement of the cerebral microcirculation. Blood soluble drag-reducing polymers (DRP), prepared from high molecular weight polyethylene oxide, target impaired microvascular perfusion by altering rheological properties blood and, until our recent reports, applied to brain. We hypothesized that DRP improve microcirculation and oxygenation TBI. were...
Brain vasogenic edema, involving disruption of the blood-brain barrier, is a common pathological condition in several neurological diseases, with heterogeneous prognosis. It sometimes reversible, as posterior reversible encephalopathy syndrome, but often irreversible and our current clinical tools are insufficient to reveal its reversibility. Here, we show that increased fractional anisotropy magnetic resonance imaging associated reversibility edema. Spontaneously, hypertensive rats-stroke...
Chronic pain often predicts the onset of psychological distress. Symptoms including anxiety and depression after chronification reportedly are caused by brain remodeling/recruitment limbic reward/aversion circuitries. Pain is primary precipitating factor that has opioid overprescribing continued overuse opioids leading to current epidemic. Yet experimental therapies fail in clinical trials. Better understanding underlying pathologies contributing needed address these chronic related issues....
Traumatic brain injury (TBI) continues to be a major cause of death and disability worldwide. This study assessed the effectiveness non-invasive vagus nerve stimulation (nVNS) in reducing lesion volume improving neurobehavioral performance rat model TBI. Animals were randomized into three experimental groups: (1) TBI with sham treatment (Control), (2) treated five lower doses (2-min) nVNS, (3) higher (2 × 2-min) nVNS. We used gammaCore nVNS device deliver stimulations. Magnetic resonance...
Objectives To investigate the occurrence of unwanted pregnancies among renal transplant recipients and to identify major contributing factors.
Microglial/macrophage activation plays a dual role in response to brain injury after stroke, promoting early neuroinflammation and benefit for neurovascular recovery. Therefore, the dynamics of stroke-induced cerebral microglial/macrophage are substantial interest. This study used novel anti-Iba-1-targeted superparamagnetic iron-platinum (FePt) nanoparticles conjunction with magnetic resonance imaging (MRI) measure spatiotemporal changes living rat four weeks post-stroke. Ischemic lesion...
Cerebral small vessel disease (SVD) contributes to approximately 50% of human dementias world-wide and pose a burden the health care system worldwide. Early endothelial/blood-brain barrier (BBB) dysfunction is an important contributor pathogenesis SVD. Sphingosine-1-phosphate (S1P), membrane-derived signaling sphingolipid, regulates BBB integrity by binding its receptor isoform 1 (S1PR1) on endothelial cells. We previously showed that activation S1PR1 using SEW2871, selective agonist,...
BACKGROUND: Blood-brain barrier (BBB) dysfunction contributes to the pathogenesis of cerebral small vessel disease. This study assessed SEW2871, a selective agonist sphingosine-1-phosphate receptor 1, as potential novel therapy for disease by targeting BBB damage using rat model METHODS: Twelve-week male and female spontaneously hypertensive stroke-prones were subjected unilateral carotid artery occlusion (UCAO) Japanese permissive diet (JPD). Three doses SEW2871 (0.5, 1.0, 5.0 mg/kg,...
Survivors of infant traumatic brain injury (TBI) are prone to chronic neurological deficits that impose lifelong individual and societal burdens. Translation novel interventions clinical trials is hampered in part by the lack truly representative preclinical tests cognition corresponding biomarkers functional outcomes. To address this gap, ability a high-dose, extended, post-injury regimen erythropoietin (EPO, 3000U/kg/dose × 6d) prevent cognitive imaging was tested postnatal day 12 (P12)...
Music plays a more important role in our life than just being an entertainment. For example, it can be used as anti-anxiety therapy of human and animals. However, the unsafe listening loud music triggers hearing loss millions young people professional musicians (rock, jazz symphony orchestra) owing to exposure damaging sound levels using personal audio devices or at noisy entertainment venues including nightclubs, discotheques, bars concerts. Therefore, is understand how affects us. In this...
Significance Tuberous sclerosis complex (TSC) is caused by mutations in TSC1 or TSC2 gene and affects multiple organs, including the kidney, where it presents with angiomyolipomata cysts that can result kidney failure. The factors promoting cyst formation tumor growth TSC are incompletely understood. Current studies demonstrate epithelia mouse models humans composed of hyperproliferating intercalated cells, along activation H + -ATPase carbonic anhydrase 2. Interfering cell proliferation...