A5001020604- Cannabis and Cannabinoid Research
- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- Drug Transport and Resistance Mechanisms
- Metabolism and Genetic Disorders
- Biochemical Analysis and Sensing Techniques
- Diet, Metabolism, and Disease
- Pharmacological Effects and Toxicity Studies
- HIV-related health complications and treatments
- Adenosine and Purinergic Signaling
- Sleep and Wakefulness Research
- Microtubule and mitosis dynamics
- Educational Reforms and Innovations
- Parkinson's Disease Mechanisms and Treatments
- Pharmacology and Obesity Treatment
- Pharmacological Effects and Assays
- Hormonal and reproductive studies
- Prenatal Substance Exposure Effects
- Medical Research and Treatments
- Ideological and Political Education
- Gastrointestinal Tumor Research and Treatment
- Drug Solubulity and Delivery Systems
- Pharmacogenetics and Drug Metabolism
- Sesame and Sesamin Research
University of Nottingham
2018-2024
Hubei University of Science and Technology
2023
The intestinal lymphatic system plays an important role in the pathophysiology of multiple diseases including lymphomas, cancer metastasis, autoimmune diseases, and human immunodeficiency virus (HIV) infection. It is thus compartment for delivery drugs order to treat associated with system. Lipophilic prodrug approaches have been used past take advantage transport processes deliver lymphatics. Most previously adopted were based on very bulky moieties such as those mimicking triglycerides...
Delivery to the brain is a challenging task due its protection by blood-brain barrier (BBB). Lipids and fatty acids are reported affect permeability of BBB, although this has not been following oral administration. Cannabidiol (CBD) high therapeutic potential in brain, therefore, work investigated CBD delivery anatomical regions administration lipid-based lipid-free vehicles. All formulations resulted short Tmax (1 h) brain-plasma ratios ≥ 3.5, with retention up 18 h post The highest was...
Abstract Although adenosine and its analogues have been assessed in the past as potential drug candidates due to important role of physiology, only little is known about their absorption following oral administration. In this work, we studied disposition pathways cordycepin, an analogue. vitro biopharmaceutical properties vivo cordycepin were rats. Despite fact that numerous studies showed efficacy dosing found intact was not absorbed administration However, 3′-deoxyinosine, a metabolite...
Oral sesame oil-based formulation facilitates the delivery of poorly water-soluble drug cannabidiol (CBD) to lymphatic system and blood circulation. However, this natural also leads considerable variability in absorption CBD. In work, performance lipid-based formulations with addition medium-chain triglyceride (MCT) or surfactants oil vehicle has been tested vitro vivo using CBD as a model drug. The lipolysis shown that MCT higher distribution into micellar phase. Further MCT-containing did...
Although natural sesame oil has been shown to facilitate the lymphatic delivery and oral bioavailability of highly lipophilic drug cannabidiol (CBD), considerable variability remains an unresolved challenge. Vegetable oils differ substantially in composition, which could lead differences promotion intestinal transport drugs. Therefore, composition sesame, sunflower, peanut, soybean, olive coconut their corresponding role as vehicles promoting CBD targeting were investigated this study. The...
Efficient delivery of highly lipophilic drugs or prodrugs to the mesenteric lymph nodes (MLN) can be achieved following oral administration with lipids. However, it remains unclear which specific MLN targeted and what extent. Moreover, efficiency drug retroperitoneal (RPLN) has not been assessed. The aim this study was assess distribution a model cannabidiol (CBD), known undergo intestinal lymphatic transport lipids, into RPLN in rats at various time-points post dosing. In vivo studies...
The establishment of latent cellular and anatomical viral reservoirs is a major obstacle to achieving cure for people infected by HIV. Mesenteric lymph nodes (MLNs) are one the most important Suboptimal levels antiretroviral (ARVs) drugs in these difficult-to-penetrate limitations current therapy (ART) regimens. This study aimed design assess highly lipophilic ester prodrugs dolutegravir (DTG) formulated with long-chain triglyceride (LCT) delivery DTG reservoir mesenteric MLNs. A number...
A simple, sensitive and cost-effective HPLC-UV bioanalytical method for determination of lopinavir (LPV) in rat human plasma was developed validated. The sample preparation procedure includes a combination protein precipitation using cold acetonitrile liquid-liquid extraction with n-hexane-ethyl acetate (7:3, v/v). good chromatographic separation achieved Phenomenex Gemini column (C18 , 150 mm × 2.0 mm, 5 μm) at 40°C gradient elution, 211 nm. Calibration curves were linear the range...
Male hypogonadism is often treated by testosterone (T) replacement therapy such as oral administration of the ester prodrug, undecanoate (TU). However, systemic exposure to T following TU very low due esterase-mediated metabolism, particularly in small intestine. The aim this work was examine esterase-inhibitory effect natural fruit extract strawberry (STW) on intestinal degradation a potential approach increasing bioavailability T. Herein, hydrolysis assessed fasted state simulated fluid...
Efficient delivery of antiretroviral agents to lymph nodes is important decrease the size HIV reservoir within lymphatic system. Lamivudine (3TC) used in first-line regimens for treatment HIV. As a highly hydrophilic small molecule, 3TC not predicted associate with chylomicrons and therefore should have negligible uptake into intestinal lymphatics following oral administration. Similarly, amounts are be transported peripheral subcutaneous (SC) injection due faster flow rate blood comparison...