A5019430648- Mental Health Treatment and Access
- Mental Health Research Topics
- Intensive Care Unit Cognitive Disorders
- Digital Mental Health Interventions
- Anesthesia and Neurotoxicity Research
- Child and Adolescent Psychosocial and Emotional Development
- Cardiac Health and Mental Health
- Maternal Mental Health During Pregnancy and Postpartum
- Tryptophan and brain disorders
- Treatment of Major Depression
- Inflammation biomarkers and pathways
- Neuroinflammation and Neurodegeneration Mechanisms
- Water Treatment and Disinfection
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Education and Learning Interventions
- Light effects on plants
- Health and Wellbeing Research
- Anesthesia and Sedative Agents
- Microbial Community Ecology and Physiology
- Animal Nutrition and Physiology
- Circular RNAs in diseases
- Sleep and related disorders
- Eicosanoids and Hypertension Pharmacology
- COVID-19 and Mental Health
- Biological and pharmacological studies of plants
Nanjing Drum Tower Hospital
2022-2025
Nanjing University
2022-2025
Shenzhen Nanshan Center for Chronic Disease Control
2021-2024
Nanjing Medical University
2022-2023
China Pharmaceutical University
2023
Guizhou Academy of Agricultural Sciences
2022-2023
Huaqiao University
2023
Shanghai Jiao Tong University
2022
Sun Yat-sen University
2021
Postoperative cognitive dysfunction (POCD) is a common postoperative complication involving the central nervous system, but underlying mechanism not well understood. Neuroinflammation secondary to surgery and anesthesia strongly correlated with POCD. A key aspect of neuroinflammation microglia activation. Triggering receptor expressed on myeloid cells (TREM)2, which highly in microglia, an innate immune that modulates function. In this study we investigated role TREM2 impairment...
The presence of heterogenous somatic symptoms frequently obscures the recognition depression in primary care. We aimed to explore association between and subthreshold (SD) Major Depressive Disorder (MDD), as well determine predictive potential identifying SD MDD care.Data were derived from Depression Cohort China study (ChiCTR registry number: 1900022145). Patient Health Questionnaire-9 (PHQ-9) was used assess by trained general practitioners (GPs), Mini International Neuropsychiatric...
Background Depression is associated with significant morbidity and human capital costs globally. Early screening for depressive symptoms timely disorder case identification intervention may improve health outcomes cost-effectiveness among affected individuals. China’s public academic communities have reached a consensus on the need to access early screening, diagnosis, treatment of depression. Objective This study aims estimate prevalence factors subthreshold Chinese residents enrolled in...
Many people living with major depressive disorder (MDD) in China do not receive treatment owing to a lack of mental health services, along significant stigma toward illness. Internet-based cognitive behavioral therapy (ICBT) has been proposed increase access care for MDD.The aims this study were (1) evaluate the efficacy ICBT symptoms patients MDD; (2) effect on anxiety symptoms, nonspecific psychological distress, general self-efficacy, depression stigma, social function, and health-related...
The current study aims to investigate the effects of synergy between quercetin and vitamin E in aged hen's diet on hatchability antioxidant levels embryo newly hatched chicks from prolonged storage eggs. A total 400 breeder laying hens 65 weeks age were selected randomly divided into 4 groups. Birds fed a basal alone (Control), diets supplemented with (Q) (0.4 g/kg) (VE) (0.2 their combination g/kg Q + 0.2 VE) for 14 weeks, respectively, determine yolk status, fertility, embryonic mortality,...
Bletilla striata is a valuable Chinese herbal medicinal plant widely used in various fields. To meet the market demand for this herb, tissue culture technology of B. was developed. However, drought stress has been significant threat to survival cultivated striata. further understand underlying mechanisms under stress, its response investigated at physiological and transcriptional levels. Our photosynthesis results show that decline net rate (Pn) leaves mainly caused by nonstomatal limitation...
Postoperative cognitive dysfunction (POCD) is characterized by impaired function following general anesthesia and surgery. Oxidative stress a significant pathophysiological manifestation underlying POCD. Previous studies have reported that the decline of nicotinamide adenine dinucleotide (NAD+) -dependent sirtuin 1 (SIRT1) contributes to activation oxidative stress. In this study, we investigated whether pretreatment mononucleotide (NMN), an NAD+ intermediate, improves in The animal model...
Due to high rates of incidence and disability, postoperative cognitive dysfunction (POCD) currently receives a lot clinical attention. Disturbance fatty acid oxidation is potential pathophysiological manifestation underlying POCD. Peroxisome proliferator-activated receptor α (PPARα) significant transcription factor that facilitates the transfer acids into mitochondria for oxidation. The role PPARα intervention in POCD warrants consideration.The present study aimed investigate whether agonist...
Abstract Background: Stressful life events (SLEs) and suicidal ideation (SI) are prevalent in persons with major depression disorder (MDD). Less is known about the underlying role of insomnia symptoms association between SLEs SI. This study sought to investigate longitudinal among SLEs, SI MDD. Methods: three-wave prospective used data collected December 2020 September 2022 from Depression Cohort China (DCC), which a large, ongoing cohort targeting at aged 18-64 years The population included...
Stressful life events (SLEs) and suicidal ideation (SI) are prevalent in persons with major depression disorder (MDD). Less is known about the underlying role of insomnia symptoms association between SLEs SI. This three-wave prospective cohort study sought to investigate longitudinal among SLEs, symptoms, SI MDD. The population included 511 MDD (mean [SD] age, 28.7 [6.7] years; 67.1% were females). Generalized estimated equations (GEEs) utilized explore exposure Additionally, a structural...
Introduction: Agitation in Alzheimer’s dementia (AAD) confers significant humanistic and economic burden; however, factors, relationships between them, which drive the extent of this burden are poorly understood. The Objectives study was to review gather evidence on AAD order develop a conceptual framework capturing its effects patients, their families, clinicians (i.e., care teams), society, can then be used guide further research into how might reduced. Methods: Evidence identified via...
Abstract Objectives Long-term inhalation anesthesia is considered to be one of the important causes postoperative cognitive dysfunction, and our previous studies have confirmed that oxidative stress damage contribute its mechanistic connection. The ACE2/Ang-(1–7)/Mas axis balances classic RAS (rat sarcoma, Ras) in body, playing an role stress. Our research focus on ACE2 (angiotensin converting enzyme 2, ACE2) investigate mechanism involved development long-term isoflurane anesthesia-induced...
Bipolar disorder is easily misdiagnosed with major depressive (MDD). The Rapid Mood Screener (RMS) was developed to address this unmet clinical need. This study aims translate and evaluated the reliability validity of RMS in Chinese adults bipolar I/II (BD-I/II).
<sec> <title>BACKGROUND</title> Many people living with major depressive disorder (MDD) in China do not receive treatment owing to a lack of mental health services, along significant stigma toward illness. Internet-based cognitive behavioral therapy (ICBT) has been proposed increase access care for MDD. </sec> <title>OBJECTIVE</title> The aims this study were (1) evaluate the efficacy ICBT symptoms patients MDD; (2) effect on anxiety symptoms, nonspecific psychological distress, general...
<sec> <title>BACKGROUND</title> Depression is associated with significant morbidity and human capital costs globally. Early screening for depressive symptoms timely disorder case identification intervention may improve health outcomes cost-effectiveness among affected individuals. China’s public academic communities have reached a consensus on the need to access early screening, diagnosis, treatment of depression. </sec> <title>OBJECTIVE</title> This study aims estimate prevalence factors...