Weihong Zhang

ORCID: 0000-0001-8997-3092
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About
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Research Areas
  • Stroke Rehabilitation and Recovery
  • Mollusks and Parasites Studies
  • Ideological and Political Education
  • Child Abuse and Trauma
  • Child and Adolescent Psychosocial and Emotional Development
  • Cerebral Palsy and Movement Disorders
  • Chinese history and philosophy
  • Adolescent Sexual and Reproductive Health
  • Balance, Gait, and Falls Prevention
  • Dialysis and Renal Disease Management
  • SARS-CoV-2 and COVID-19 Research
  • Atomic and Subatomic Physics Research
  • Physical Activity and Health
  • Sexual Assault and Victimization Studies
  • Migration, Health and Trauma
  • Global Health Workforce Issues
  • Histone Deacetylase Inhibitors Research
  • Neurological Disease Mechanisms and Treatments
  • Racial and Ethnic Identity Research
  • Hepatitis B Virus Studies
  • Osteomyelitis and Bone Disorders Research
  • Protein Degradation and Inhibitors
  • Transcranial Magnetic Stimulation Studies
  • Anesthesia and Neurotoxicity Research
  • Blood groups and transfusion

Ghent University
2013-2025

Jiangxi Academy of Agricultural Sciences
2024

Animal Science Research Institute
2024

SK Life Science (United States)
2024

Guangzhou First People's Hospital
2024

Guangzhou Medical University
2024

Zhengzhou University
2010-2023

Université Libre de Bruxelles
2023

Clemson University
2023

Nanjing Medical University
2005-2022

Summary Aims To evaluate the effectiveness of repetitive transcranial magnetic stimulation ( rTMS ) on motor recovery after stroke using a prospective, double‐blind, randomized, sham‐controlled study. Methods Patients with unilateral subcortical infarction in middle cerebral artery territory within 1 week onset were enrolled. The patients randomly divided into an treatment group and sham group. We performed high‐frequency or two groups. Motor functional scores assessed pre‐ post‐ /sham at...

10.1111/cns.12762 article EN CNS Neuroscience & Therapeutics 2017-10-02

Background Stroke is a major health threat and the leading cause of mortality disability in China. The aims this study were to identify possible influencing factors health-related quality life (HRQoL) its domain-specific contents stroke patients rural areas Methods A total 1,709 aged 36–79 years from baseline data Henan Rural Cohort ( n = 39,259) included cross-sectional study. Chinese version European Quality Life Five Dimension (including mobility, self-care, usual activities,...

10.3389/fpubh.2022.810185 article EN cc-by Frontiers in Public Health 2022-04-05

Avian leukosis virus subgroup K (ALV-K) is a new of avian (ALV) that was first identified in Chinese native chickens recent years. To further understand the molecular epidemiology and evolutionary diversity ALV-K, this study investigated 73,664 chicken plasma samples collected from Jiangxi flocks. The results showed ALV-J most predominant ALV subtype chickens, with high positivity rate 4.34%. From 2021 to 2023, there gradual upward trend proportion positive numbers ALV-K among ALV-positive...

10.3389/fmicb.2024.1341201 article EN cc-by Frontiers in Microbiology 2024-02-08

Most of the individuals infected with SARS coronavirus (SARS-CoV) spontaneously recovered without clinical intervention. However, immunological correlates associated patients' recovery are currently unknown. In this report, we have sequentially monitored 30 patients over a two-year period to characterize temporal changes in SARS-CoV-specific antibody responses as well cytotoxic T cell (CTL) responses. We found persistence robust and CTL all study subjects throughout period, moderate decline...

10.1371/journal.pone.0000024 article EN cc-by PLoS ONE 2006-12-20

The aim of this study was to develop a quick and economical method for the diagnosis fungal keratitis. Corneal scrapings were obtained from consecutive patients (n = 165) with clinically suspected keratitis used culture prepare two smears. Potassium hydroxide stain followed by calcofluor white added one smear Giemsa second. In comparison results, sensitivity potassium wet mounts 81.0% following addition 96.6% in diagnosing keratitis, whereas using 39.7% 98.3%. detected 23 cases bacterial...

10.1177/147323001003800609 article EN Journal of International Medical Research 2010-12-01

Our study aimed to figure out brain functional reorganization evidence after repetitive transcranial magnetic stimulation (rTMS) using the resting-state resonance imaging (rsfMRI).Twelve patients with unilateral subcortex lesion in middle cerebral artery territory were recruited. Seven of them received a 10-day rTMS treatment beginning at about 5 days stroke onset. The remaining five sham treatment. RsfMRI and motor scores obtained before or rTMS.The group showed recovery according...

10.1111/cns.12593 article EN CNS Neuroscience & Therapeutics 2016-07-15

Objectives The caregiving experience includes both caregiver burdens and benefits finding. However, the obtained by family caregivers of stroke survivors in Chinese community dwellings are unknown. objective this study was to explore experienced dwellings. Design A qualitative descriptive design used, fulfilling consolidated criteria for Standards Reporting Qualitative Research reporting guidelines. Semi-structured interviews were conducted with 20 survivors. audiotaped, transcribed...

10.1136/bmjopen-2020-038344 article EN cc-by-nc BMJ Open 2020-10-01

Inhibition of estrogen receptor alpha (ERα) signaling is an established therapeutic approach for the treatment ER-positive (ER+) breast cancers, but new strategies are urgently needed to overcome clinical resistance. In present study, we describe discovery and extensive evaluation ERD-12310A as exceptionally potent orally efficacious PROTAC degrader ERα. achieved a DC

10.1021/acs.jmedchem.4c01401 article EN Journal of Medicinal Chemistry 2024-11-25

Objective: The rising rate of suicidal behavior among adolescents is a growing concern, and sex differences may induce differential exposure to prescription drug misuse or behavior. We estimated, Chinese adolescents, (1) the prevalence nonmedical use drugs, ideation suicide attempts; (2) whether drugs was independently associated with (3) there were in associations. Methods: This secondary analysis data drawn from 2015 National School-based Adolescents Health Survey. A total 94,911 students...

10.1177/0004867418814944 article EN Australian & New Zealand Journal of Psychiatry 2018-12-10

Despite the development of highly effective therapies for treatment estrogen receptor α (ERα)-positive human breast cancer, clinical resistance to current requires novel therapeutic strategies. Herein, we report discovery ERD-1233 as a potent and orally efficacious ERα degrader designed using PROTAC technology. was developed based on Lasofoxifene ER binding moiety cereblon ligand through extensive optimization linker. potently effectively reduces protein in vitro achieves excellent oral...

10.1021/acs.jmedchem.4c01521 article EN Journal of Medicinal Chemistry 2024-11-01

Objective. We evaluated the whole-spine computed tomography (CT) findings in patients with synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome to improve our understanding of this rare disease. Methods. Whole-spine CT images obtained 69 SAPHO were reviewed. For each individual, a total 25 vertebrae for distribution affected vertebrae, manifestations vertebral lesions, symmetry location lesions on involvement pattern, narrowing adjacent intervertebral disc space....

10.3899/jrheum.161075 article EN The Journal of Rheumatology 2017-03-01

Objective. Stroke survivors with motor deficits often have pyramidal tract atrophy caused by degeneration of corticospinal fibers. The authors hypothesized that the degree correlates severity impairment in patients chronic stroke and predicts response to rehabilitation training. Methods. They performed a post hoc analysis 42 hemiparetic (>6 months) who had been randomized either 6 weeks bilateral arm training rhythmic auditory cueing (BATRAC) or dose-matched therapeutic exercise (DMTE)....

10.1177/1545968310382001 article EN Neurorehabilitation and neural repair 2010-10-13

Prehypertension is common in China and associated with an increased risk of cardiovascular disease. The present study estimated the current prevalence prehypertension its association clustering other modifiable factors (CRFs) among adults suburban Beijing.A cross-sectional survey a representative sample 19 003 aged 18 to 76 years was carried out 2007. Questionnaire data information on blood pressure, anthropometric characteristics, laboratory measurements were collected.The age-standardized...

10.2188/jea.je20110022 article EN cc-by Journal of Epidemiology 2011-01-01

Importance A better understanding of the psychosocial health resettled child and adolescent refugees associated premigration postmigration factors may help this population integrate effectively. Objective To estimate associations multidomain with after resettlement among young different ages. Design, Setting, Participants This cross-sectional study used wave 3 data from Building a New Life in Australia (BNLA) cohort study, as they represented first time BNLA included module targeting...

10.1001/jamanetworkopen.2023.5841 article EN cc-by-nc-nd JAMA Network Open 2023-04-06

Abstract Background The differential diagnosis of diffuse cystic lung disease (DCLD) is a clinical challenge. We wish to analyze the distribution etiology DCLD based on data from single lymphangioleiomyomatosis (LAM) clinic. Methods All patients at LAM Clinic Peking Union Medical College Hospital between January 2006 and December 2019 were analyzed. Information demographic, clinical, radiological, pathological features was collected. Results A total 1010 with CT scan evaluated. sum...

10.1186/s13023-021-01905-2 article EN cc-by Orphanet Journal of Rare Diseases 2021-06-12
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