A5030798907- Tuberous Sclerosis Complex Research
- Cancer-related molecular mechanisms research
- Vascular Tumors and Angiosarcomas
- Circular RNAs in diseases
- Sarcoidosis and Beryllium Toxicity Research
- MicroRNA in disease regulation
- Corporate Governance and Law
- Histiocytic Disorders and Treatments
- Medical Imaging and Pathology Studies
- Air Quality and Health Impacts
- Climate Change and Health Impacts
- Genetic and Kidney Cyst Diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Eosinophilic Disorders and Syndromes
- RNA Research and Splicing
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2022
Peking Union Medical College Hospital
2015-2021
China-Japan Friendship Hospital
2021
Icahn School of Medicine at Mount Sinai
2021
Academy of Medical Sciences
2021
Purpose: Circular RNAs (circRNAs) regulate other RNA transcripts by competing for shared microRNAs, which play roles in the pathogenesis of many diseases, including chronic obstructive pulmonary disease (COPD). However, role circRNAs COPD remains unknown. This study aimed to investigate expression profile and COPD. Patients Methods: Twenty-one patients twenty-one normal controls were recruited. Total collected from peripheral blood mononuclear cells (PBMCs) each participant. CircRNAs...
Abstract Background The differential diagnosis of diffuse cystic lung disease (DCLD) is a clinical challenge. We wish to analyze the distribution etiology DCLD based on data from single lymphangioleiomyomatosis (LAM) clinic. Methods All patients at LAM Clinic Peking Union Medical College Hospital between January 2006 and December 2019 were analyzed. Information demographic, clinical, radiological, pathological features was collected. Results A total 1010 with CT scan evaluated. sum...
Transbronchial lung biopsy (TBLB) in the diagnosis of lymphangioleiomyomatosis (LAM) is not a common approach, although TBLB often performed diffuse diseases. We aimed to examine diagnostic value and safety LAM patients based on data collected our center.We reviewed registered Clinic from December 8, 2006, 31, 2019. All with definite or probable who had been examined using were included. available pathology slides by an experienced pathologist. complications medical records confirmed...
Abstract Background Bronchial asthma is a heterogeneous disease with distinct phenotypes and underlying pathophysiological mechanisms. Long non-coding RNAs (lncRNAs) are involved in numerous functionally different biological physiological processes. The aim of this study was to identify differentially expressed lncRNAs mRNAs patients further explore the functions interactions between mRNAs. Methods Ten 9 healthy controls were enrolled study. RNA isolated from peripheral blood mononuclear...
The clinical definite diagnosis of lymphangioleiomyomatosis(LAM) can be made based on the presentations, serology and radiology, but lung biopsy remains a gold standard to achieve diagnosis. Pathology is important in differential for LAM other cystic diseases. Transbronchial biopsy(TBLB)is less invasive safer than methods. TBLB has been widely applied diffuse Its value LAM, however, matter debate. According available literature, positive rate 33%-87%, occurrence pneumothorax bleeding 6% 4%...
Abstract BACKGROUND: Transbronchial lung biopsy (TBLB) in the diagnosis of lymphangioleiomyomatosis (LAM) is not a common approach, although TBLB often performed diffuse diseases. We aimed to examine diagnostic value and safety LAM patients based on data collected our center. METHODS: reviewed registered with Clinic hospital from December 8, 2006, 30, 2019. All definite or probable who had been examined using were included. available pathology slides by an experienced pathologist....
Abstract Background : Bronchial asthma is a heterogeneous disease with distinct phenotypes and underlying pathophysiological mechanisms. Long non-coding RNAs (lncRNAs) are involved in numerous functionally different biological physiological processes. The aim of this study was to identify differentially expressed lncRNAs mRNAs patients further explore the functions interactions between mRNAs. Methods Ten 9 healthy controls were enrolled study. RNA isolated from peripheral blood mononuclear...