Wenjian Lai

ORCID: 0000-0003-2515-6231
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About
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Research Areas
  • Child and Adolescent Psychosocial and Emotional Development
  • Impact of Technology on Adolescents
  • Child Development and Digital Technology
  • Maternal Mental Health During Pregnancy and Postpartum
  • Suicide and Self-Harm Studies
  • Adolescent and Pediatric Healthcare
  • Smoking Behavior and Cessation
  • Child Abuse and Trauma
  • Health, Environment, Cognitive Aging
  • Cardiovascular Health and Risk Factors
  • Bipolar Disorder and Treatment
  • LGBTQ Health, Identity, and Policy
  • Mental Health Treatment and Access
  • Sleep and related disorders
  • Aging and Gerontology Research
  • Bullying, Victimization, and Aggression
  • Air Quality and Health Impacts
  • Nutritional Studies and Diet
  • Physical Activity and Health
  • Sexuality, Behavior, and Technology
  • Energy and Environment Impacts
  • Psychological and Temporal Perspectives Research
  • Antioxidant Activity and Oxidative Stress
  • Psychological Well-being and Life Satisfaction
  • Health disparities and outcomes

Sun Yat-sen University
2022-2025

Ghent University
2025

Key Laboratory of Guangdong Province
2025

Bridge University
2022-2024

Health Net
2022

University Health Network
2022

University of Toronto
2022

Previous researches have not distinguished the between-person effects from within-person when exploring relationship between self-esteem, coping styles, and anxiety symptoms among adolescents. To address this gap, study investigated reciprocal associations in a three-wave longitudinal panel survey, using an analytical strategy that disaggregates variance.Data was drawn Longitudinal Study of Adolescents' Mental Behavioral Well-being Research conducted 10 public schools Guangdong province...

10.1186/s13034-023-00564-4 article EN cc-by Child and Adolescent Psychiatry and Mental Health 2023-02-08

Abstract Background Unhealthy lifestyle behaviors among adolescents have emerged as a significant public health concern worldwide, however, there is little investigation on the impact of unhealthy non-suicidal self-injury (NSSI), suicidal ideation (SI) and suicide attempt (SA). This study aimed to investigate prevalence seven well their associations with NSSI, SI SA, explore whether aforementioned differ across sex. Methods A total 74,152 were included in this via multi-stage, stratified...

10.1186/s13034-024-00742-y article EN cc-by Child and Adolescent Psychiatry and Mental Health 2024-05-29

Major depressive disorder (MDD) is the most prevalent mental health globally. However, association between symptom trajectories in early period and subsequent outcomes remains not fully elucidated. This study aimed to delineate during initial phase of treatment, identify baseline characteristics associated with these trajectories, explore quality life suicidal ideation. Participants were from Depression Cohort China. The diagnosis MDD was assessed using Mini-International Neuropsychiatric...

10.1186/s12888-025-06743-1 article EN cc-by-nc-nd BMC Psychiatry 2025-03-31

Suboptimal medication adherence is a major reason for failure in the management of depressive disorder (MDD), childhood trauma might be an essential risk factor suboptimal adherence. This study aimed to comprehensively explore associations between different types and among patients with MDD, test whether resilience has moderating effects on foregoing associations.Participants were from Depression Cohort China (ChiCTR registry number 1900022145), 282 MDD completed both baseline 12-weeks...

10.1186/s12888-022-04297-0 article EN cc-by BMC Psychiatry 2022-10-14

Abstract Background Depression among adolescents is a seriously disabling public health problem with an extremely high prevalence. Identifying risk factors of depression at early stage important to reduce the disease burden. Childhood maltreatment (CM) one major for depression. The key mediating processes that how CM affects development depression, however, still need further clarification. present study tested effect self-esteem, internalizing problems, and externalizing problems between...

10.1186/s12888-023-04654-7 article EN cc-by BMC Psychiatry 2023-03-20

Introduction: Problematic gaming (PG) is a serious issue among adolescents worldwide, and there evidence suggesting that school bullying behaviors may be associated with increased rates of PG. This study aimed to examine the associations between PG adolescents, focus on sex effects. Methods: A total 20,197 participants were recruited from 2023 School-based Chinese Adolescents Health Survey. Information about was measured. Sampling weights utilized estimate prevalence, weighted logistic...

10.1186/s12888-024-06267-0 article EN cc-by-nc-nd BMC Psychiatry 2024-11-16

Abstract Background Depressive symptoms among adolescents are a serious health concern around the world. Altered DNA methylation in FK506 binding protein 5 ( FKBP5 ) gene has been reported to regulate stress response, which be closely associated with depressive symptoms. However, most of contributing studies have conducted adults and relatively few considered effect disparate social influences sex differences on persons The present study aimed test associations explore possible foregoing...

10.1186/s12888-022-04392-2 article EN cc-by BMC Psychiatry 2022-11-30

Previous studies have shown a relationship between fine particulate matter (PM2.5) exposure and an increased risk of neonatal disorders. Considering the huge burden disorders, we assessed spatiotemporal trends disorders caused by ambient household PM2.5 at global, regional, national levels from 1990 to 2019. The number, rate, population attributable fraction (PAF) PM2.5-related disability-adjusted life years (DALYs) in 204 countries territories 2019 were obtained Global Burden Disease Study...

10.1016/j.ecoenv.2023.114560 article EN cc-by-nc-nd Ecotoxicology and Environmental Safety 2023-01-23

Background Anxiety symptoms are common mental health problems among adolescents worldwide. This study aimed to explore (1) the longitudinal association between childhood maltreatment and anxiety symptoms, (2) DNA methylation of FKBP5 gene, (3) gene with at follow-up. Methods A nested case-control design was conducted identify a case group control from aged 13–18 years in Guangzhou 2019 2020. Adolescents baseline follow-up were considered group, while those without group. The groups matched...

10.3389/fpsyt.2022.761898 article EN cc-by Frontiers in Psychiatry 2022-02-03

Abstract Background Less is known about the underlying role of social support in association between non-medical use prescription drugs (NUMPD) and emotional behavioral Problems (EBPs). This study sought to explore among NMUPD, EBPs Chinese youth. Methods A multi-stage, stratified-cluster, random-sampling method was utilized invite 23,364 adolescents aged 10–21 years from Guangdong province complete standard questionnaires. Data on were collected using Strengths Difficulties Questionnaire...

10.21203/rs.3.rs-3915886/v1 preprint EN cc-by Research Square (Research Square) 2024-02-07

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10.2139/ssrn.4769104 preprint EN 2024-01-01

Abstract Background This study aimed to investigate the associations of time from waking first cigarette (TWFC) with all-cause mortality, cardiovascular disease (CVD) mortality and incident CVD among people smoking. Methods Data were UK Biobank, including 32 519 smoking aged 40–70 years. TWFC was investigated using a touch-screen questionnaire. Outcomes included incidence CVD, ischemic heart (IHD) stroke. Results Compared participants reporting >120 min, those between 61 120 min (HR,...

10.1093/pubmed/fdae242 article EN Journal of Public Health 2024-09-05

The 24-hour movement guidelines (24-HMG) include screen time (ST), sleep duration, and physical activity. Previous studies have explored the associations of adherence to 24-HMG with depression anxiety symptoms among adolescents, ignoring changes in behaviors. This study aimed examine whether were associated adolescents.

10.1186/s13034-024-00836-7 article EN cc-by Child and Adolescent Psychiatry and Mental Health 2024-11-10

While the association between screen time (ST) and psychosocial well-being has been extensively examined, limited studies have investigated dynamic patterns of ST, their impact on subsequent among adolescents. Therefore, this longitudinal study aimed to examine ST trajectories Chinese Data were drawn from Longitudinal Study Adolescents' Mental Behavioral Well-being Research (Registration No. ChiCTR1900022032). The final analysis included 1480 participants who completed baseline two follow-up...

10.1186/s12888-024-06329-3 article EN cc-by-nc-nd BMC Psychiatry 2024-11-30

Abstract The global aging population raises concerns about heart failure (HF), yet its association with accelerated biological age (BA) remains inadequately understood. We aimed to examine the longitudinal between BA acceleration and incident HF risk, assess modifying effect on genetic susceptibility, how much mediates impact of modifiable health behaviors HF. analyzed 274,608 UK Biobank participants without at baseline. Two accelerations (Biological Age Acceleration [BioAgeAccel] Phenotypic...

10.1111/acel.14430 article EN cc-by Aging Cell 2024-12-11
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