A5044934066- Mental Health Treatment and Access
- Mental Health Research Topics
- Child and Adolescent Psychosocial and Emotional Development
- Digital Mental Health Interventions
- Tryptophan and brain disorders
- Suicide and Self-Harm Studies
- Maternal Mental Health During Pregnancy and Postpartum
- Sleep and related disorders
- Treatment of Major Depression
- Bipolar Disorder and Treatment
- Adolescent and Pediatric Healthcare
- Health, Environment, Cognitive Aging
- Trace Elements in Health
- Genetic Associations and Epidemiology
- Heavy Metal Exposure and Toxicity
- Hormonal Regulation and Hypertension
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- COVID-19 and Mental Health
- Health disparities and outcomes
- Youth Substance Use and School Attendance
- Stress Responses and Cortisol
- Cardiac Health and Mental Health
- Health and Wellbeing Research
- Fatty Acid Research and Health
- Child Development and Digital Technology
Shenzhen Nanshan Center for Chronic Disease Control
2018-2025
Centre for Chronic Disease Control
2022
The presence of heterogenous somatic symptoms frequently obscures the recognition depression in primary care. We aimed to explore association between and subthreshold (SD) Major Depressive Disorder (MDD), as well determine predictive potential identifying SD MDD care.Data were derived from Depression Cohort China study (ChiCTR registry number: 1900022145). Patient Health Questionnaire-9 (PHQ-9) was used assess by trained general practitioners (GPs), Mini International Neuropsychiatric...
Background Depression is associated with significant morbidity and human capital costs globally. Early screening for depressive symptoms timely disorder case identification intervention may improve health outcomes cost-effectiveness among affected individuals. China’s public academic communities have reached a consensus on the need to access early screening, diagnosis, treatment of depression. Objective This study aims estimate prevalence factors subthreshold Chinese residents enrolled in...
Suboptimal medication adherence is a major reason for failure in the management of depressive disorder (MDD), childhood trauma might be an essential risk factor suboptimal adherence. This study aimed to comprehensively explore associations between different types and among patients with MDD, test whether resilience has moderating effects on foregoing associations.Participants were from Depression Cohort China (ChiCTR registry number 1900022145), 282 MDD completed both baseline 12-weeks...
Many people living with major depressive disorder (MDD) in China do not receive treatment owing to a lack of mental health services, along significant stigma toward illness. Internet-based cognitive behavioral therapy (ICBT) has been proposed increase access care for MDD.The aims this study were (1) evaluate the efficacy ICBT symptoms patients MDD; (2) effect on anxiety symptoms, nonspecific psychological distress, general self-efficacy, depression stigma, social function, and health-related...
This study aimed to explore the longitudinal associations of rumination with suicidal ideation and suicide attempts in individuals major depressive disorder (MDD). Participants were derived from Depression Cohort China (DCC). Those who completed at least one follow-up visit during 12 months included analysis. Dimensions including brooding reflection each measured using five items Ruminative Responses Scale. Suicidal was assessed Beck Scale for Suicide Ideation. also all analyzed generalized...
This study sought to assess the differences in mental health conditions among general population, quarantined population and healthcare workers during COVID-19 outbreak China. An online rapid assessment captured depressive anxiety symptoms, sleep quality data. A total of 2689 participants (n=374 n=403 workers, n=1912 population) were included final statistical analysis. The proportion individuals with mild and/or serious depression higher when compared (58.6% vs. 25.1%vs. 48.6%, P<0.001;...
(1) Background: Increasing evidence shows that sedentary behaviors are associated with neuropsychiatric disorders (NPDs) and thus may be a modifiable factor to target for the prevention of NPDs. However, direction causality relationship remain unknown; could increase or decrease risk NPDs, and/or NPDs engagement in behaviors. (2) Methods: This Mendelian randomization (MR) study two samples included independent genetic variants related (n = 408,815), Alzheimer’s disease (AD; n 63,926),...
Genome-wide association studies (GWASs) have identified risk loci for suicide attempt (SA), but deciphering how they confer SA remains largely unknown. This study aims to identify the key proteins and gain insights into pathogenesis. We integrated data from brain proteome (N = 376) blood 35,559) combined it with largest GWAS summary statistics date 518,612). A comprehensive set of methods was employed, including Mendelian randomization (MR), Steiger filtering, Bayesian colocalization,...
This large-scale study aimed to test, among Chinese adolescents, the association between problematic Internet use (PIU), non-medical of prescription drugs (NMUPD), and depressive symptoms, as well mediating effects NMUPD on associations above. used data from 2017 National School-based Adolescents Health Survey, 24,345 students' questionnaires qualified for analyses. Generalized linear mixed models path were performed. In without mediation, PIU was associated with symptoms (unstandardized β...
Previous observational studies reported associations between non-steroidal anti-inflammatory drugs (NSAIDs) and major depressive disorder (MDD), however, these are often inconsistent underlying biological mechanisms still poorly understood. We conducted a two-sample Mendelian randomisation (MR) study to examine relationships genetic variants NSAID target gene expression or DNA methylation (DNAm) using publicly available expression, quantitative trait loci (eQTL mQTL) data variant-disease...
Objective: Pain and affective disorders have clear clinical relevance; however, very few studies investigated the association between pain bipolar disorder. This study brain activity of patients with disorder (BPs) undergoing tonic assessed interaction emotion. Methods: Ten BPs ten healthy controls (HCs) were exposed to emotional pictures (positive, neutral, or negative), only (pain session), along (combined session). A moderate was induced by infusion hypertonic saline (5% NaCl) into right...
Abstract Individuals with schizophrenia (SCZ) have, on average, a 10- to 20-year shorter expected life span than the rest of population, primarily due cardiovascular disease comorbidity. Genome-wide association studies (GWAS) have previously been used separately identify common variants in SCZ and cardiometabolic traits. However, genetic jointly influencing both traits remain be fully characterised. To assess overlaps (if any) between architecture traits, we conditional false discovery rate...
Abstract Background: Stressful life events (SLEs) and suicidal ideation (SI) are prevalent in persons with major depression disorder (MDD). Less is known about the underlying role of insomnia symptoms association between SLEs SI. This study sought to investigate longitudinal among SLEs, SI MDD. Methods: three-wave prospective used data collected December 2020 September 2022 from Depression Cohort China (DCC), which a large, ongoing cohort targeting at aged 18-64 years The population included...