A5100428380- Gut microbiota and health
- Tryptophan and brain disorders
- Epigenetics and DNA Methylation
- Machine Learning in Healthcare
- LGBTQ Health, Identity, and Policy
- Youth Substance Use and School Attendance
- Colorectal Cancer Screening and Detection
- Infant Nutrition and Health
- Probiotics and Fermented Foods
- COVID-19 and Mental Health
- Neuroendocrine regulation and behavior
- Heavy Metal Exposure and Toxicity
- Suicide and Self-Harm Studies
- Nutritional Studies and Diet
- Sleep and related disorders
- Psychological and Educational Research Studies
- Psychological Well-being and Life Satisfaction
- Gene Regulatory Network Analysis
- MicroRNA in disease regulation
- Bioinformatics and Genomic Networks
- Color perception and design
- Plant Virus Research Studies
- Autism Spectrum Disorder Research
- Insect Resistance and Genetics
- Esophageal Cancer Research and Treatment
Shanxi Medical University
2021-2025
Hefei University of Technology
2020-2025
Shanxi Academy of Medical Sciences
2025
Columbia University
2023-2024
Harvard University
2023
Beijing Normal University
2022
Southeast University
2020-2021
Shaanxi Provincial People's Hospital
2021
University of Illinois Urbana-Champaign
2021
Sun Yat-sen University
2018-2020
Abstract Inference and analysis of gene regulatory networks (GRNs) require software that integrates multi-omic data from various sources. The Network Zoo (netZoo; netzoo.github.io) is a collection open-source methods to infer GRNs, conduct differential network analyses, estimate community structure, explore the transitions between biological states. netZoo builds on our ongoing development methods, harmonizing implementations in computing languages allow better integration these tools into...
Chronic lead exposure is associated with the development of neurodegenerative diseases, characterized by long-term memory decline. However, whether this pathogenesis could be prevented through adjusting gut microbiota not yet understood. To address issue, pregnant rats and their female offspring were treated (125 ppm) or separately extra probiotics (1010 organisms/rat/day) till adulthood. For results, dysfunction was alleviated treatment multispecies probiotics. Meanwhile, composition...
Social dominance is a ubiquitous phenomenon among social animals, including humans. To date, individual attributes leading to (after contest) remain largely elusive. Here, we report that socially dominant rats can be distinguished from subordinates based on their intestinal microbiota. When dysbiosis induced, are predisposed subordinate state, while dysbiotic reclaim following microbiota transplantation. Winning hosts characterized by core microbes, majority of which associated with butyrate...
Lead (Pb) exposure during early life has been associated with an increased risk of neurodevelopmental disorders, including learning and memory deficits. The intestinal flora, via the microbiome–gut–brain axis, could play a significant role in nervous system. However, effects probiotics on ameliorating Pb-induced deficits are still unclear. In this study, we showed that adolescent Pb (150 ppm) for 2 months impaired spatial ability, accompanied by decreasing diversity gut microbiota, abundance...
<title>Abstract</title> As a prevalent neurodevelopmental disease, whether ASD (autism spectrum disorder) can be ameliorated by the early use of single microbe remains unknown. Here we report that <italic>Lacticaseibacillus rhamnosus</italic> GR-1 (LGR-1) prevented occurrence autism-like behaviors when administered exclusively to pregnant mice, as evidenced improved and restored E/I balance in prefrontal cortex male pups. In parallel, offspring microbiome was reshaped LGR-1 treatment,...
Royal jelly (RJ) has long been considered a crucial dietary component in dictating caste differentiation honeybees. As nutritional additive, royal imparts broad range of benefits to mammals and humans; however, its precise impact on the social hierarchy these advanced animals is not yet fully understood. This study aims determine whether can be transferred rats alter their ranks uncover underlying mechanisms. A submissive model was established by inducing dysbiosis rats, via persistent...
Allergic rhinitis (AR) is an immunoglobulin E (IgE)-mediated inflammatory disorder. This study attempts to identify AR-related differential expressed genes (DEGs) and determine potential targets for AR. We employed bioinformatics analysis screen hub DEGs AR, their performances in distinguishing AR were assessed by receiver operating characteristic (ROC) curves. Quantitative reverse-transcription polymerase chain reaction (qRT-PCR) Western blot was used quantify Granzyme A (GZMA) ovalbumin...
Cystic echinococcosis (CE) is a chronic infectious disease caused by Echinococcus granulosus. To confirm whether the infection impacts on gut microbiota, we established mouse model of E. granulosus in this study whereby BALB/c mice were infected with micro-cysts After 4 months infection, fecal samples collected for high-throughput sequencing hypervariable regions 16S rRNA gene. Sequence analysis revealed total 13,353 operational taxonomic units (OTUs) only 40.6% OTUs having genera reference...
The outbreak of COVID-19 epidemic continues to unfold globally, which harms the public's mental health. Adolescents' health is affected by social isolation and lockdown during epidemic. implicit theory thoughts-emotion-behavior states that individuals with a growth mindset believe thoughts, emotions, behaviors can be changed through effort tend persist in pursuing higher goals maintain enthusiasm as well cope stress resiliently, thus having gritty levels This study aimed explore role grit...
Abstract Studies have found that human microbiome is associated with and predictive of health diseases. Many statistical methods developed for data focus on different distance metrics can capture various information in microbiomes. Prediction models were also data, including deep learning convolutional neural networks consider both taxa abundance profiles taxonomic relationships among microbial from a phylogenetic tree. suggested outcome could associate multiple forms profiles. In addition...
Abnormal sleep and nonmedical use of prescription drugs are known to be factors associated with suicidal behavior, but the nature association between weekday duration behavior has not been elucidated. Nonmedical may play a mediator role in mentioned above.There were total 3,273 high school students interviewed at baseline response rate 96.8% followed up one year (retention rate, 96.1%). The mean (SD) age was 13.7 (1.0) years.Data drawn from longitudinal data School-based Chinese Adolescents...
Abstract Mitochondria are central eukaryotic organelles in cellular metabolism and ATP production. Mitochondrial DNA (mtDNA) alterations have been implicated the development of colorectal cancer (CRC). However, there few reports on association between mtDNA haplogroups or single nucleotide polymorphisms (SNPs) risk CRC. The 286 Northern Han Chinese CRC patients were sequenced by next‐generation sequencing technology. MtDNA data from 811 population controls collected two public sets. Then,...
Excess weight status may increase the risk of suicidality among sexual minority females, but few studies have examined this disparity in males. This study association between and suicide attempts Chinese male adolescents tested whether body mass index (BMI) had a moderating effect on that association. Data were collected from 7th to 12th graders seven randomly selected provinces China 2015 School-Based Adolescents Health Survey. In total, 72,409 students completed questionnaires regarding...
Background: The aim of this study is to interrogate the prophylactic effect probiotic on lead-induced spatial memory impairment, as well underlying mechanisms based gut microbiota. Methods: Rats were exposed postnatally 100 ppm lead acetate during lactation (from postnatal day 1 21), establish deficits model. A bacterium, namely Lacticaseibacillus rhamnosus , was administered by drinking into pregnant rats with a dosage 10 9 CFU/rat/day till birth. At week 8 (PNW8), subjected Morris water...
Abstract Motivation Research on human microbiome has suggested associations with health, opening opportunities to predict health outcomes using microbiome. Studies have also that diverse forms of taxa such as rare are evolutionally related and abundant unrelated could be associated or predictive a outcome. Although prediction models were developed for data, no currently exist use multiple microbiome–outcome associations. Results We MK-BMC, Multi-Kernel framework Boosted distance Metrics...
With the fast development of packaging design, usability evaluation has been paid much attention to.On other hand, with popularity eye movement experiment, method based on experimental data introduced into system.This paper, taking MG mask as target, evaluates design by experiment in terms packaging-opening and shelf display.The results indicate that customers accepted design.The opening first-layer was time-consuming, however, inner needed to improve.Finally, some suggestions are presented...
As the coronavirus 2019 (COVID-19) pandemic continues to be a global public health emergency, many individuals are facing mental issues due challenges that accompany this pandemic. Previous studies report people around world experiencing high levels of stress and therefore struggling manage their emotions well-being. While there numerous different factors influence how an individual may dealing with related stressors, one factor does seem level is coping mechanisms. In study, we aim...